Luis Castillo has appeared in 111 games for the Mariners in the regular-season and playoffs in his career.
| NAME | G | SEASON | TM | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 13 | 2022 |  SEA | 5 | 3 | .625 | 13 | 2.94 | 89 | 0 | 0 | 0 | 79.2 | 66 | 26 | 29 | 8 | 17 | 5 | 0 | 0 | 320 | 0 | 10.05 | 1.92 | 5.24 | 0.90 | 27.8 | 5.3 | 1.04 | .289 | 3.28 | 70 | 2.38 | 62 | 7.46 | 6.7 |
| 2 | | L. Castillo | 33 | 2023 | SEA | 13 | 9 | .591 | 33 | 3.34 | 219 | 0 | 0 | 0 | 197.0 | 160 | 73 | 81 | 28 | 56 | 5 | 0 | 0 | 802 | 3 | 10.01 | 2.56 | 3.91 | 1.28 | 27.3 | 7.0 | 1.10 | .267 | 3.70 | 83 | 3.80 | 93 | 7.31 | 6.6 |
| 3 | | L. Castillo | 30 | 2024 | SEA | 11 | 12 | .478 | 30 | 3.64 | 175 | 0 | 0 | 0 | 175.1 | 158 | 71 | 73 | 25 | 47 | 5 | 0 | 2 | 719 | 0 | 8.98 | 2.41 | 3.72 | 1.28 | 24.3 | 6.5 | 1.17 | .285 | 3.75 | 97 | 3.91 | 100 | 8.11 | 0 |
| 4 | | L. Castillo | 35 | 2025 | SEA | 12 | 9 | .571 | 34 | 3.52 | 167 | 0 | 0 | 0 | 189.0 | 174 | 74 | 79 | 24 | 51 | 7 | 1 | 0 | 781 | 3 | 7.95 | 2.43 | 3.27 | 1.14 | 21.4 | 6.5 | 1.19 | .282 | 3.76 | 88 | 3.70 | 92 | 8.29 | 2.5 |
| Total | 111 | 41 | 33 | .554 | 110 | 3.43 | 650 | 0 | 0 | 0 | 641.0 | 558 | 244 | 262 | 85 | 171 | 22 | 1 | 2 | 2,622 | 6 | 9.13 | 2.40 | 3.80 | 1.19 | 24.8 | 6.5 | 1.14 | .279 | 3.68 | 87 | 3.62 | 91 | 7.83 | 15.9 |
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R
766
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