Luis Castillo has a record of 3-4 with an ERA of 3.44 and 66 strikeouts in 12 appearances against the AL East in the regular-season and playoffs at home in his career.
| NAME | DATE | TM | OPP | DEC | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 7/8/2022 |  CIN | vs |  TBR | 1 | 1.29 | 8 | 0 | 0 | 0 | 7.0 | 4 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 26 | 0 | |
| 2 |  | L. Castillo | 8/9/2022 |  SEA | vs |  NYY | 1 | 0.00 | 7 | 0 | 0 | 0 | 8.0 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 27 | 0 | |
| 3 | | L. Castillo | 7/2/2023 | SEA | vs | TBR | 1 | 6.00 | 6 | 0 | 0 | 0 | 6.0 | 7 | 4 | 6 | 2 | 0 | 0 | 0 | 0 | 27 | 0 | |
| 4 | | L. Castillo | 8/11/2023 | SEA | vs |  BAL | W | 1 | 1.50 | 8 | 0 | 0 | 0 | 6.0 | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 22 | 0 |
| 5 | | L. Castillo | 3/28/2024 | SEA | vs |  BOS | L | 1 | 7.20 | 5 | 0 | 0 | 0 | 5.0 | 6 | 4 | 4 | 1 | 2 | 0 | 0 | 0 | 23 | 0 |
| 6 | | L. Castillo | 7/5/2024 | SEA | vs |  TOR | W | 1 | 1.35 | 8 | 0 | 0 | 0 | 6.2 | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 23 | 0 |
| 7 | | L. Castillo | 8/28/2024 | SEA | vs | TBR | W | 1 | 3.18 | 4 | 0 | 0 | 0 | 5.2 | 6 | 2 | 2 | 1 | 2 | 0 | 0 | 0 | 24 | 0 |
| 8 | | L. Castillo | 5/9/2025 | SEA | vs | TOR | L | 1 | 9.00 | 3 | 0 | 0 | 0 | 5.0 | 7 | 5 | 5 | 1 | 2 | 0 | 0 | 0 | 24 | 0 |
| 9 | | L. Castillo | 5/14/2025 | SEA | vs | NYY | 1 | 1.50 | 6 | 0 | 0 | 0 | 6.0 | 6 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 25 | 0 | |
| 10 | | L. Castillo | 6/18/2025 | SEA | vs | BOS | L | 1 | 4.50 | 5 | 0 | 0 | 0 | 6.0 | 3 | 3 | 3 | 2 | 2 | 1 | 0 | 0 | 24 | 0 |
| 11 | | L. Castillo | 8/8/2025 | SEA | vs | TBR | 1 | 2.57 | 5 | 0 | 0 | 0 | 7.0 | 5 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 25 | 0 | |
| 12 | | L. Castillo | 10/16/2025 | SEA | vs | TOR | L | 1 | 11.57 | 1 | 0 | 0 | 0 | 2.1 | 5 | 3 | 3 | 1 | 1 | 0 | 0 | 0 | 13 | 0 |
| Total | 12 | 3.44 | 66 | 0 | 0 | 0 | 70.2 | 56 | 27 | 29 | 12 | 18 | 1 | 0 | 0 | 283 | 0 |
Some of the information used here was obtained free of charge from Retrosheet.
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