Luis Castillo has a 32-26 record with an ERA of 3.42 and 521 strikeouts in 85 appearances for the Mariners in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 2022 |  SEA | 11 | 4 | 2 | .667 | 11 | 3.17 | 77 | 0 | 0 | 0 | 65.1 | 55 | 23 | 26 | 6 | 17 | 4 | 0 | 0 | 266 | 0 | 10.61 | 2.34 | 4.53 | 0.83 | 28.9 | 6.4 | 1.10 | .302 | 3.58 | 85 | 2.91 | 76 | 7.58 | 6.7 |
| 2 | | L. Castillo | 2023 | SEA | 33 | 13 | 9 | .591 | 33 | 3.34 | 219 | 0 | 0 | 0 | 197.0 | 160 | 73 | 81 | 28 | 56 | 5 | 0 | 0 | 802 | 3 | 10.01 | 2.56 | 3.91 | 1.28 | 27.3 | 7.0 | 1.10 | .267 | 3.70 | 83 | 3.80 | 93 | 7.31 | 6.6 |
| 3 | | L. Castillo | 2024 | SEA | 30 | 11 | 12 | .478 | 30 | 3.64 | 175 | 0 | 0 | 0 | 175.1 | 158 | 71 | 73 | 25 | 47 | 5 | 0 | 2 | 719 | 0 | 8.98 | 2.41 | 3.72 | 1.28 | 24.3 | 6.5 | 1.17 | .285 | 3.75 | 97 | 3.91 | 100 | 8.11 | 0 |
| 4 | | L. Castillo | 2025 | SEA | 11 | 4 | 3 | .571 | 11 | 3.32 | 50 | 0 | 0 | 0 | 62.1 | 60 | 23 | 23 | 4 | 21 | 1 | 0 | 0 | 265 | 0 | 7.22 | 3.03 | 2.38 | 0.58 | 18.9 | 7.9 | 1.30 | .296 | 3.32 | 90 | 3.35 | 86 | 8.66 | 3.8 |
| Total | 85 | 32 | 26 | .552 | 85 | 3.42 | 521 | 0 | 0 | 0 | 500.0 | 433 | 190 | 203 | 63 | 141 | 15 | 0 | 2 | 2,052 | 3 | 9.38 | 2.54 | 3.70 | 1.13 | 25.4 | 6.9 | 1.15 | .282 | 3.65 | 89 | 3.67 | 92 | 7.79 | 17.2 |
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