Luis Castillo had a 20-28 record with an ERA of 3.49 and 448 strikeouts in 70 appearances between the 2020 and 2022 seasons.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 2020 |  CIN | 12 | 4 | 6 | .400 | 12 | 3.21 | 89 | 1 | 0 | 0 | 70.0 | 62 | 25 | 31 | 5 | 24 | 1 | 0 | 0 | 292 | 1 | 11.44 | 3.09 | 3.71 | 0.64 | 30.5 | 8.2 | 1.23 | .329 | 3.99 | 68 | 2.64 | 57 | 7.97 | 15.2 |
| 2 | | L. Castillo | 2021 | CIN | 33 | 8 | 16 | .333 | 33 | 3.98 | 192 | 0 | 0 | 0 | 187.2 | 181 | 83 | 94 | 19 | 75 | 7 | 0 | 4 | 803 | 1 | 9.21 | 3.60 | 2.56 | 0.91 | 23.9 | 9.3 | 1.36 | .318 | 4.51 | 90 | 3.74 | 84 | 8.68 | 14.5 |
| 3 |  | L. Castillo | 2022 | TOT | 25 | 8 | 6 | .571 | 25 | 2.99 | 167 | 0 | 0 | 0 | 150.1 | 118 | 50 | 56 | 13 | 45 | 8 | 0 | 0 | 615 | 0 | 10.00 | 2.69 | 3.71 | 0.78 | 27.2 | 7.3 | 1.08 | .275 | 3.35 | 75 | 3.07 | 76 | 7.06 | 15.9 |
| Total | 70 | 20 | 28 | .417 | 70 | 3.49 | 448 | 1 | 0 | 0 | 408.0 | 361 | 158 | 181 | 37 | 144 | 16 | 0 | 4 | 1,710 | 2 | 9.88 | 3.18 | 3.11 | 0.82 | 26.2 | 8.4 | 1.24 | .304 | 3.99 | 81 | 3.30 | 76 | 7.96 | 45.5 |
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