Luis Castillo has a record of 6-5 with an ERA of 2.60 and 89 strikeouts in 15 appearances against the Pirates in his career.
| NAME | DATE | TM | OPP | DEC | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 8/26/2017 |  CIN | vs |  PIT | L | 1 | 1.29 | 9 | 0 | 0 | 0 | 7.0 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 24 | 0 |
| 2 | | L. Castillo | 9/1/2017 | CIN | @ | PIT | 1 | 4.50 | 5 | 0 | 0 | 0 | 4.0 | 3 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 17 | 0 | |
| 3 | | L. Castillo | 4/6/2018 | CIN | @ | PIT | L | 1 | 7.20 | 3 | 0 | 0 | 0 | 5.0 | 6 | 4 | 4 | 0 | 3 | 0 | 0 | 0 | 24 | 0 |
| 4 | | L. Castillo | 5/24/2018 | CIN | vs | PIT | W | 1 | 3.00 | 5 | 0 | 0 | 0 | 6.0 | 4 | 2 | 2 | 1 | 2 | 0 | 0 | 0 | 23 | 0 |
| 5 | | L. Castillo | 6/16/2018 | CIN | @ | PIT | L | 1 | 5.40 | 2 | 0 | 0 | 0 | 5.0 | 6 | 3 | 3 | 2 | 2 | 0 | 0 | 0 | 23 | 0 |
| 6 | | L. Castillo | 3/28/2019 | CIN | vs | PIT | 1 | 1.59 | 8 | 0 | 0 | 0 | 5.2 | 2 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 22 | 0 | |
| 7 | | L. Castillo | 5/27/2019 | CIN | vs | PIT | 1 | 1.69 | 4 | 0 | 0 | 0 | 5.1 | 6 | 1 | 3 | 0 | 4 | 1 | 0 | 0 | 26 | 0 | |
| 8 | | L. Castillo | 7/31/2019 | CIN | vs | PIT | W | 1 | 1.29 | 7 | 0 | 0 | 0 | 7.0 | 6 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 27 | 0 |
| 9 | | L. Castillo | 9/4/2020 | CIN | @ | PIT | W | 1 | 3.00 | 8 | 0 | 0 | 0 | 6.0 | 7 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 26 | 0 |
| 10 | | L. Castillo | 9/16/2020 | CIN | vs | PIT | W | 1 | 0.00 | 10 | 0 | 0 | 0 | 7.0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 24 | 0 |
| 11 | | L. Castillo | 4/7/2021 | CIN | vs | PIT | W | 1 | 0.00 | 5 | 0 | 0 | 0 | 7.0 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 25 | 0 |
| 12 | | L. Castillo | 10/1/2021 | CIN | @ | PIT | 1 | 1.69 | 5 | 0 | 0 | 0 | 5.1 | 6 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 23 | 0 | |
| 13 | | L. Castillo | 5/14/2022 | CIN | @ | PIT | L | 1 | 5.40 | 2 | 0 | 0 | 0 | 5.0 | 4 | 3 | 3 | 1 | 1 | 0 | 0 | 0 | 19 | 0 |
| 14 |  | L. Castillo | 5/27/2023 |  SEA | vs | PIT | W | 1 | 0.00 | 10 | 0 | 0 | 0 | 6.0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 22 | 0 |
| 15 | | L. Castillo | 8/17/2024 | SEA | @ | PIT | L | 1 | 6.75 | 6 | 0 | 0 | 0 | 5.1 | 5 | 4 | 4 | 2 | 3 | 0 | 0 | 0 | 23 | 0 |
| Total | 15 | 2.60 | 89 | 0 | 0 | 0 | 86.2 | 66 | 25 | 27 | 7 | 29 | 2 | 0 | 0 | 348 | 0 |
Some of the information used here was obtained free of charge from Retrosheet.
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