The New York Mets had their highest run differential in a game versus the Phillies on August 16, 2018, with a differential of 20 runs.

Interpreted as:

mets largest margins of runs in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mets	20	8/16/2018	NYM	@	PHI	W 24-4	52	24	25	7	1	3	19	7	1	5	1	0	61	43	11	1	0	1	2	.481	.550	.827	1.377
2	Mets	18	5/26/1964	NYM	@	CHC	W 19-1	49	19	23	3	2	1	17	3	2	8	1	0	54	33	6	0	0	0	1	.469	.519	.673	1.192
3	Mets	17	9/11/2020	NYM	@	TOR	W 18-1	47	18	19	5	0	3	17	6	2	10	0	0	55	33	8	0	0	0	1	.404	.491	.702	1.193
4	Mets	17	9/25/2016	NYM	vs	PHI	W 17-0	37	17	14	3	0	2	15	9	4	9	0	0	50	23	5	0	0	0	1	.378	.540	.622	1.162
5	Mets	16	6/27/2012	NYM	@	CHC	W 17-1	40	17	16	6	0	4	17	7	0	4	1	0	48	34	10	0	1	0	2	.400	.479	.850	1.329
6	Mets	16	8/30/1999	NYM	@	HOU	W 17-1	45	17	21	2	0	5	17	5	0	7	1	0	51	38	7	1	0	0	2	.467	.520	.844	1.364
7	Mets	16	4/17/1976	NYM	@	PIT	W 17-1	48	17	21	6	0	2	17	2	0	5	0	1	51	33	8	1	0	0	0	.438	.460	.688	1.148
8	Mets	14	4/28/2025	NYM	@	WSH	W 19-5	47	19	21	3	1	4	19	6	2	9	0	0	56	38	8	0	1	0	0	.447	.518	.809	1.326
9	Mets	14	7/8/2006	NYM	vs	FLA	W 17-3	40	17	16	2	2	3	17	4	1	4	0	0	45	31	7	0	0	0	0	.400	.467	.775	1.242
10	Mets	14	8/24/2005	NYM	@	ARI	W 18-4	43	18	20	7	1	5	16	7	1	3	1	0	53	44	13	1	1	1	1	.465	.538	1.023	1.562
11	Mets	14	4/19/1998	NYM	@	CIN	W 14-0	41	14	16	5	1	0	14	10	0	5	0	1	52	23	6	0	1	0	0	.390	.500	.561	1.061
12	Mets	14	6/6/1992	NYM	@	PIT	W 15-1	42	15	18	3	0	3	14	6	0	5	0	1	49	30	6	0	1	0	1	.429	.490	.714	1.204
13	Mets	14	8/7/1971	NYM	@	ATL	W 20-6	45	20	21	1	0	2	18	7	0	4	1	0	55	28	3	1	2	1	3	.467	.519	.622	1.141
14	Mets	14	7/29/1965	NYM	@	CHC	W 14-0	39	14	11	3	0	2	8	7	0	5	1	0	46	20	5	0	0	0	2	.282	.391	.513	.904
15	Mets	13	7/29/2024	NYM	vs	MIN	W 15-2	38	15	17	4	0	1	15	7	1	5	1	0	49	24	5	0	3	0	0	.447	.510	.632	1.142
16	Mets	13	6/9/2021	NYM	@	BAL	W 14-1	40	14	16	4	0	6	14	2	1	8	0	0	43	38	10	0	0	0	3	.400	.442	.950	1.392
17	Mets	13	9/6/2020	NYM	vs	PHI	W 14-1	42	14	17	7	0	5	13	2	2	14	0	1	46	39	12	0	0	1	0	.405	.457	.929	1.385
18	Mets	13	9/12/2018	NYM	vs	MIA	W 13-0	39	13	14	2	1	3	12	3	0	6	0	0	43	27	6	1	0	0	0	.359	.405	.692	1.097
19	Mets	13	7/25/2015	NYM	vs	LAD	W 15-2	44	15	21	5	0	4	14	5	1	8	0	0	50	38	9	0	0	1	1	.477	.540	.864	1.404
20	Mets	13	5/16/2015	NYM	vs	MIL	W 14-1	39	14	16	4	0	3	14	3	0	9	0	0	42	29	7	0	0	0	2	.410	.452	.744	1.196
21	Mets	13	9/5/2010	NYM	@	CHC	W 18-5	47	18	21	4	0	2	18	9	0	8	2	0	57	31	6	0	1	1	1	.447	.526	.660	1.186
22	Mets	13	4/2/2008	NYM	@	FLA	W 13-0	39	13	17	6	0	2	13	4	0	6	0	0	45	29	8	1	1	0	2	.436	.477	.744	1.221
23	Mets	13	9/29/2007	NYM	vs	FLA	W 13-0	44	13	19	3	0	3	13	4	0	5	0	0	49	31	6	1	0	0	0	.432	.479	.705	1.184
24	Mets	13	9/30/2006	NYM	@	WSH	W 13-0	39	13	12	2	0	5	13	7	0	8	1	0	47	29	7	1	0	1	0	.308	.413	.744	1.157
25	Mets	13	6/11/2006	NYM	@	ARI	W 15-2	42	15	15	7	1	0	15	10	1	13	3	0	54	24	8	1	0	0	0	.357	.491	.571	1.062