I didn't find anything for this season, but Elly De La Cruz had the most strikeouts with 300+ at-bats in 2024, with 218 strikeouts.

Interpreted as:

minimum 300 at bats the most strikeouts by a player this regular season

	NAME	SO	AB	SEASON	TM	G	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Elly De La Cruz E. De La Cruz	218	618	2024	CIN	160	105	160	36	10	25	76	69	6	67	16	696	291	71	2	1	2	12	.259	.339	.471	.809	103	21.5	.349	118	14.9
2	Ezequiel Tovar E. Tovar	200	655	2024	COL	157	83	176	45	4	26	78	23	4	6	5	694	307	75	5	7	1	16	.269	.295	.469	.763	89	7.9	.324	95	-4.4
3	Kyle Schwarber K. Schwarber	197	573	2024	PHI	150	110	142	22	0	38	104	106	5	5	3	692	278	60	0	8	4	6	.248	.366	.485	.851	112	31	.366	135	29.2
4	Teoscar Hernández T. Hernández	188	589	2024	LAD	154	84	160	32	2	33	99	53	8	12	3	651	295	67	0	1	3	7	.272	.339	.501	.840	102	26	.360	133	25.9
5	Zack Gelof Z. Gelof	188	497	2024	OAK	138	60	105	20	2	17	49	38	4	25	3	547	180	39	3	5	0	7	.211	.270	.362	.632	49	-14.9	.276	83	-10.9
6	Ryan McMahon R. McMahon	185	567	2024	COL	153	68	137	28	0	20	65	69	3	4	6	643	225	48	0	4	4	9	.242	.325	.397	.722	78	2.7	.315	89	-8.8
7	Oneil Cruz O. Cruz	181	541	2024	PIT	146	72	140	34	3	21	76	51	3	22	1	599	243	58	0	4	5	8	.259	.324	.449	.773	80	10	.331	110	7.1
8	Adolis García A. García	177	580	2024	TEX	154	68	130	27	0	25	85	45	6	11	5	637	232	52	0	6	2	12	.224	.284	.400	.684	67	-7.4	.296	92	-5.8
9	Brent Rooker B. Rooker	177	546	2024	OAK	145	82	160	26	2	39	112	59	5	11	3	614	307	67	0	4	4	5	.293	.365	.562	.927	112	40.5	.392	164	45
10	Eugenio Suárez E. Suárez	176	571	2024	ARI	158	90	146	28	2	30	101	49	9	2	1	640	268	60	0	11	0	10	.256	.319	.469	.788	89	14	.337	115	11.6
11	Cal Raleigh C. Raleigh	176	546	2024	SEA	153	73	120	16	0	34	100	70	6	6	1	628	238	50	0	6	4	7	.220	.312	.436	.748	80	6.3	.323	117	12.3
12	Willy Adames W. Adames	173	610	2024	MIL	161	93	153	33	0	32	112	74	1	21	4	688	282	65	0	3	3	12	.251	.331	.462	.794	98	17.6	.342	119	15.8
13	Paul Goldschmidt P. Goldschmidt	173	599	2024	STL	154	70	147	33	1	22	65	47	2	11	0	650	248	56	0	2	2	20	.245	.302	.414	.716	76	-0.2	.310	100	-0.4
14	Pete Alonso P. Alonso	172	608	2024	NYM	162	91	146	31	0	34	88	70	13	3	0	695	279	65	0	4	4	14	.240	.329	.459	.788	98	16.6	.340	122	18
15	Colton Cowser C. Cowser	172	499	2024	BAL	153	77	121	24	3	24	69	52	7	9	4	561	223	51	0	3	2	9	.242	.321	.447	.768	75	9.6	.331	119	12.3
16	Aaron Judge A. Judge	171	559	2024	NYY	158	122	180	36	1	58	144	133	9	10	0	703	392	95	0	2	20	22	.322	.458	.701	1.159	176	93.7	.476	219	95.5
17	Bryan De La Cruz B. De La Cruz	170	584	2024	TOT	149	61	136	25	0	21	68	29	3	5	2	621	224	46	0	5	1	10	.233	.271	.384	.654	59	-13.8	.283	77	-16.8
18	Matt Olson M. Olson	170	600	2024	ATL	162	78	148	37	1	29	98	71	9	0	0	685	274	67	0	5	5	15	.247	.333	.457	.790	96	16.1	.339	117	13.6
19	Marcell Ozuna M. Ozuna	170	606	2024	ATL	162	96	183	31	0	39	104	74	3	1	0	687	331	70	0	4	2	23	.302	.378	.546	.925	127	46.6	.395	154	44
20	Jose Siri J. Siri	170	402	2024	TBR	130	50	75	16	1	18	47	31	7	14	7	446	147	35	2	4	0	5	.187	.255	.366	.620	38	-14.1	.271	79	-10.9
21	Randy Arozarena R. Arozarena	169	549	2024	TOT	154	77	120	33	0	20	60	73	22	20	10	648	213	53	0	4	0	7	.219	.332	.388	.720	81	5.3	.320	114	10.6
22	Ian Happ I. Happ	168	569	2024	CHC	153	89	138	34	2	25	86	80	6	13	2	657	251	61	0	2	1	7	.243	.341	.441	.782	93	16.3	.341	122	16.9
23	Taylor Ward T. Ward	163	585	2024	LAA	156	73	144	26	2	25	75	63	7	6	4	663	249	53	0	8	0	11	.246	.323	.426	.748	86	8.1	.325	111	8.2
24	Shohei Ohtani S. Ohtani	162	636	2024	LAD	159	134	197	38	7	54	130	81	6	59	4	728	411	99	0	5	10	7	.310	.390	.646	1.036	156	70.5	.431	181	70.3
25	Michael Busch M. Busch	162	496	2024	CHC	152	73	123	28	2	21	65	63	4	2	1	567	218	51	0	4	1	9	.248	.335	.440	.775	78	12	.336	118	12.5