The Chicago White Sox finished 1st in the AL Central in 2021 with a record of 93-69. They won their division.
AL Central
| TEAM | W | L | PCT | GB | HOME | ROAD | L10 | STRK | |
|---|---|---|---|---|---|---|---|---|---|
 | y-White Sox | 93 | 69 | .574 | 0.0 | 53-28 | 40-41 | 7-3 | L1 |
 | Indians | 80 | 82 | .494 | 13.0 | 40-41 | 40-41 | 5-5 | W1 |
 | Tigers | 77 | 85 | .475 | 16.0 | 42-39 | 35-46 | 3-7 | W1 |
 | Royals | 74 | 88 | .457 | 19.0 | 39-42 | 35-46 | 5-5 | L2 |
 | Twins | 73 | 89 | .451 | 20.0 | 38-43 | 35-46 | 6-4 | W2 |
NL Central
| TEAM | W | L | PCT | GB | HOME | ROAD | L10 | STRK | |
|---|---|---|---|---|---|---|---|---|---|
 | y-Brewers | 95 | 67 | .586 | 0.0 | 45-36 | 50-31 | 4-6 | L4 |
 | w-Cardinals | 90 | 72 | .556 | 5.0 | 45-36 | 45-36 | 7-3 | L2 |
 | Reds | 83 | 79 | .512 | 12.0 | 44-37 | 39-42 | 5-5 | W1 |
 | Cubs | 71 | 91 | .438 | 24.0 | 39-42 | 32-49 | 4-6 | W2 |
 | Pirates | 61 | 101 | .377 | 34.0 | 37-44 | 24-57 | 4-6 | L1 |
NL West
| TEAM | W | L | PCT | GB | HOME | ROAD | L10 | STRK | |
|---|---|---|---|---|---|---|---|---|---|
 | y-Giants | 107 | 55 | .660 | 0.0 | 54-27 | 53-28 | 8-2 | W1 |
 | w-Dodgers | 106 | 56 | .654 | 1.0 | 58-23 | 48-33 | 9-1 | W7 |
 | Padres | 79 | 83 | .488 | 28.0 | 45-36 | 34-47 | 2-8 | L1 |
 | Rockies | 74 | 87 | .460 | 32.5 | 48-33 | 26-54 | 3-7 | L2 |
 | Diamondbacks | 52 | 110 | .321 | 55.0 | 32-49 | 20-61 | 4-6 | W2 |
y - clinched division
w - clinched wild card
x - clinched playoff berth
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