The New York Yankees had the highest run differential by a team in 1998, with a differential of 309 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	309	1998	162	.704	114	48	5,643	965	1,625	290	31	207	907	653	57	1,025	153	63	6,444	2,598	528	32	59	34	145	.288	.364	.460	.825
2	Astros	254	1998	162	.630	102	60	5,641	874	1,578	326	28	166	818	621	72	1,122	155	51	6,441	2,458	520	58	49	52	146	.280	.356	.436	.792
3	Braves	245	1998	162	.654	106	56	5,484	826	1,489	297	26	215	794	548	61	1,062	98	43	6,215	2,483	538	76	46	37	104	.272	.342	.453	.795
4	Red Sox	147	1998	162	.568	92	70	5,601	876	1,568	338	35	205	827	541	70	1,049	72	39	6,299	2,591	578	35	52	32	144	.280	.348	.463	.810
5	Padres	114	1998	162	.605	98	64	5,490	749	1,390	292	30	167	715	604	48	1,072	79	37	6,243	2,243	489	56	45	40	112	.253	.330	.409	.739
6	Giants	106	1998	163	.546	89	74	5,628	845	1,540	292	26	161	800	678	44	1,040	102	51	6,484	2,367	479	81	53	53	123	.274	.353	.421	.774
7	Indians	71	1998	162	.549	89	73	5,616	850	1,530	334	30	198	811	630	41	1,061	143	60	6,376	2,518	562	30	59	35	123	.272	.347	.448	.795
8	Rangers	69	1998	162	.543	88	74	5,672	940	1,637	314	32	201	894	595	39	1,045	82	47	6,401	2,618	547	41	54	27	137	.289	.357	.462	.819
9	Mets	61	1998	162	.543	88	74	5,510	706	1,425	289	24	136	671	572	37	1,049	62	46	6,255	2,170	449	88	48	55	126	.259	.330	.394	.724
10	Blue Jays	48	1998	163	.543	88	74	5,580	816	1,482	316	19	221	776	564	87	1,132	184	81	6,323	2,499	556	43	49	43	108	.266	.340	.448	.787
11	Cubs	39	1998	163	.552	90	73	5,649	831	1,494	250	34	212	788	601	39	1,223	65	44	6,393	2,448	496	67	37	51	123	.264	.337	.433	.771
12	Orioles	32	1998	162	.488	79	83	5,565	817	1,520	303	11	214	783	593	58	903	86	48	6,304	2,487	528	44	44	30	136	.273	.347	.447	.794
13	Cardinals	28	1998	163	.512	83	79	5,593	810	1,444	292	30	223	781	676	42	1,179	133	41	6,413	2,465	545	68	34	65	117	.258	.341	.441	.781
14	Angels	4	1998	162	.525	85	77	5,630	787	1,530	314	27	147	739	510	48	1,028	93	45	6,278	2,339	488	49	41	31	122	.272	.335	.415	.751
15	Mariners	4	1998	161	.472	76	85	5,628	859	1,553	321	28	234	822	558	57	1,081	115	39	6,327	2,632	583	36	48	26	107	.276	.345	.468	.812
16	Dodgers	-9	1998	162	.512	83	79	5,459	669	1,374	209	27	159	630	447	36	1,056	137	53	6,076	2,114	395	91	43	31	98	.252	.310	.387	.698
17	Reds	-10	1998	162	.475	77	85	5,496	750	1,441	298	28	138	723	608	37	1,107	95	42	6,268	2,209	464	78	49	39	133	.262	.337	.402	.739
18	Rockies	-29	1998	162	.475	77	85	5,632	826	1,640	333	36	183	791	469	37	949	67	47	6,277	2,594	552	98	41	29	148	.291	.347	.461	.808
19	Athletics	-62	1998	162	.457	74	88	5,490	804	1,413	295	13	149	755	633	55	1,122	131	47	6,282	2,181	457	58	46	22	120	.257	.338	.397	.735
20	Pirates	-68	1998	163	.426	69	93	5,493	650	1,395	271	35	107	613	393	91	1,060	159	51	6,111	2,057	413	78	56	22	102	.254	.311	.374	.686
21	White Sox	-70	1998	163	.494	80	82	5,585	861	1,516	291	38	198	806	551	47	916	127	46	6,280	2,477	527	38	59	34	119	.271	.339	.444	.782
22	Twins	-84	1998	162	.432	70	92	5,641	734	1,499	285	32	115	691	506	45	915	112	54	6,262	2,193	432	18	52	33	155	.266	.328	.389	.717
23	Phillies	-95	1998	162	.463	75	87	5,617	713	1,482	286	36	126	672	508	45	1,080	97	45	6,300	2,218	448	65	65	44	110	.264	.326	.395	.721
24	Brewers	-105	1998	162	.457	74	88	5,541	707	1,439	266	17	152	673	532	66	1,039	81	59	6,232	2,195	435	61	32	36	135	.260	.330	.396	.726
25	Devil Rays	-131	1998	162	.389	63	99	5,555	620	1,450	267	43	111	579	473	37	1,107	120	73	6,156	2,136	421	53	38	24	127	.261	.321	.385	.706