The San Francisco Giants had the highest run differential by a team in 2000, with a differential of 178 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Giants	178	2000	162	.599	97	65	5,519	925	1,535	304	44	226	889	709	51	1,032	79	39	6,418	2,605	574	73	66	60	131	.278	.362	.472	.834
2	White Sox	139	2000	162	.586	95	67	5,646	978	1,615	325	33	216	926	591	53	960	119	42	6,406	2,654	574	55	61	28	140	.286	.356	.470	.826
3	Indians	134	2000	162	.556	90	72	5,683	950	1,639	310	30	221	889	685	51	1,057	113	34	6,512	2,672	561	41	52	27	134	.288	.367	.470	.837
4	Athletics	134	2000	161	.565	91	70	5,560	947	1,501	281	23	239	908	750	52	1,159	40	15	6,432	2,545	543	26	44	32	147	.270	.360	.458	.817
5	Mariners	127	2000	162	.562	91	71	5,497	907	1,481	300	26	198	869	775	48	1,073	122	56	6,444	2,427	524	63	61	34	129	.269	.361	.442	.803
6	Cardinals	116	2000	162	.586	95	67	5,478	887	1,481	259	25	235	841	675	84	1,253	87	51	6,369	2,495	519	79	53	33	116	.270	.356	.455	.812
7	Braves	96	2000	162	.586	95	67	5,489	810	1,490	274	26	179	758	595	59	1,010	148	56	6,275	2,353	479	87	45	38	127	.271	.346	.429	.775
8	Rockies	71	2000	162	.506	82	80	5,660	968	1,664	320	53	161	905	601	42	907	131	61	6,453	2,573	534	75	75	64	126	.294	.362	.455	.816
9	Dodgers	69	2000	162	.531	86	76	5,481	798	1,408	265	28	211	756	668	51	1,083	95	42	6,312	2,362	504	66	46	42	129	.257	.341	.431	.771
10	Mets	69	2000	162	.580	94	68	5,486	807	1,445	281	20	198	761	675	45	1,037	66	46	6,327	2,360	499	70	51	42	122	.263	.346	.430	.776
11	Reds	60	2000	163	.525	85	77	5,635	825	1,545	302	36	200	794	559	64	995	100	38	6,372	2,519	538	56	58	60	137	.274	.343	.447	.790
12	Yankees	57	2000	161	.540	87	74	5,556	871	1,541	294	25	205	833	631	57	1,007	99	48	6,310	2,500	524	16	50	42	134	.277	.354	.450	.804
13	Red Sox	47	2000	162	.525	85	77	5,630	792	1,503	316	32	167	755	611	42	1,019	43	30	6,371	2,384	515	40	48	40	115	.267	.341	.423	.764
14	Diamondbacks	38	2000	162	.525	85	77	5,527	792	1,466	282	44	179	756	535	59	975	97	44	6,240	2,373	505	61	58	37	114	.265	.333	.429	.763
15	Tigers	-4	2000	162	.488	79	83	5,644	823	1,553	307	41	177	785	562	43	982	83	38	6,340	2,473	525	42	49	22	142	.275	.343	.438	.781
16	Angels	-5	2000	162	.506	82	80	5,628	864	1,574	309	34	236	837	608	47	1,024	93	52	6,373	2,659	579	47	43	43	126	.280	.352	.472	.825
17	Astros	-6	2000	162	.444	72	90	5,570	938	1,547	289	36	249	900	673	83	1,129	114	52	6,444	2,655	574	57	61	57	154	.278	.361	.477	.837
18	Blue Jays	-47	2000	162	.512	83	79	5,677	861	1,562	328	21	244	826	526	60	1,026	89	34	6,326	2,664	593	29	34	32	130	.275	.341	.469	.810
19	Royals	-51	2000	162	.475	77	85	5,709	879	1,644	281	27	150	831	511	48	840	121	35	6,394	2,429	458	56	70	28	139	.288	.348	.425	.773
20	Padres	-63	2000	162	.469	76	86	5,560	752	1,413	279	37	157	714	602	46	1,177	131	53	6,290	2,237	473	39	43	50	123	.254	.330	.402	.732
21	Marlins	-66	2000	161	.491	79	82	5,509	731	1,441	274	29	160	691	540	60	1,184	168	55	6,202	2,253	463	42	51	39	100	.262	.331	.409	.740
22	Brewers	-86	2000	163	.451	73	89	5,563	740	1,366	297	25	177	708	620	61	1,245	72	44	6,354	2,244	499	61	49	47	126	.246	.325	.403	.729
23	Pirates	-95	2000	162	.426	69	93	5,643	793	1,506	320	31	168	749	564	66	1,032	86	40	6,369	2,392	519	59	37	41	133	.267	.339	.424	.762
24	Devil Rays	-109	2000	161	.429	69	92	5,505	733	1,414	253	22	162	692	558	51	1,022	90	46	6,206	2,197	437	52	40	25	126	.257	.329	.399	.728
25	Orioles	-119	2000	162	.457	74	88	5,549	794	1,508	310	22	184	750	558	49	900	126	65	6,237	2,414	516	27	54	34	148	.272	.341	.435	.776