Between the 1880 and 2022 seasons, the New York Yankees had the highest run differential by a team, with a differential of 12,922 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	12,922	18,690	.570	10,602	8,000	637,277	90,879	169,498	28,086	5,457	16,785	84,385	67,170	4,808	91,668	11,429	2,734	721,999	258,853	50,328	9,571	3,173	2,778	10,397	.266	.339	.406	.745
2	Giants	7,485	21,399	.536	11,382	9,854	730,562	99,084	192,492	30,753	6,987	15,187	88,622	67,098	5,529	96,227	16,366	3,096	817,737	282,780	52,927	11,631	2,917	3,980	9,924	.263	.329	.387	.716
3	Dodgers	5,819	21,315	.531	11,234	9,942	726,272	95,896	189,793	30,381	6,951	13,573	86,183	67,476	4,984	97,261	17,068	3,493	814,488	274,795	50,905	12,756	2,924	3,664	9,711	.261	.327	.378	.706
4	Red Sox	3,577	18,977	.518	9,796	9,098	649,422	88,609	173,445	32,380	5,543	14,167	82,120	65,665	4,640	92,183	9,329	2,469	733,555	259,412	52,090	10,574	3,254	2,942	11,297	.267	.337	.399	.737
5	Cubs	2,934	21,661	.512	11,007	10,499	740,158	99,067	193,698	32,676	7,174	14,804	86,531	66,985	5,124	101,919	15,449	2,996	828,055	285,134	54,654	12,989	2,799	3,485	9,758	.262	.326	.385	.711
6	Guardians	2,211	18,989	.512	9,684	9,214	647,469	85,963	171,676	30,544	5,447	13,558	79,417	61,537	4,675	91,890	11,576	3,294	728,356	253,788	49,549	11,426	3,249	2,469	10,281	.265	.332	.392	.724
7	Cardinals	2,084	20,282	.514	10,351	9,800	693,838	90,793	184,581	31,217	7,015	12,441	82,922	62,980	5,053	95,144	14,790	3,547	776,852	267,151	50,673	11,938	3,043	3,740	9,885	.266	.330	.385	.715
8	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
9	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
10	Reds	769	21,515	.504	10,775	10,601	733,319	96,508	191,308	31,778	7,488	13,900	85,733	65,487	5,309	98,889	17,717	3,298	819,861	279,762	53,166	12,622	2,956	3,627	9,503	.261	.325	.382	.706
11	Braves	749	21,618	.501	10,745	10,720	739,079	95,916	191,870	31,076	6,120	14,450	84,782	66,069	4,928	96,996	13,866	3,011	825,532	278,536	51,646	12,668	2,788	3,620	10,106	.260	.323	.377	.700
12	Grays	636	578	.605	346	226	20,882	3,072	5,157	835	256	78	292	1,051					21,933	6,738	1,169					.247		.323
13	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
14	Astros	486	9,656	.501	4,831	4,820	327,589	40,999	83,458	15,295	2,129	7,969	38,558	31,207	2,741	60,139	6,925	3,067	368,149	126,918	25,393	3,996	2,616	3,094	7,116	.255	.322	.387	.710
15	White Sox	411	18,985	.503	9,492	9,390	642,972	82,763	167,341	27,652	5,527	11,945	76,022	61,170	5,142	88,841	13,411	3,420	724,767	241,882	45,124	12,329	3,154	2,433	10,254	.260	.328	.376	.704
16	Blue Jays	383	7,228	.498	3,598	3,627	247,803	33,522	64,585	12,878	1,445	7,872	31,793	22,930	2,260	46,089	4,373	1,904	276,499	103,969	22,195	1,473	2,033	1,361	5,638	.261	.326	.420	.746
17	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
18	Tigers	295	19,012	.503	9,512	9,407	648,474	87,427	171,662	29,028	6,212	14,193	80,444	64,402	4,325	93,367	11,111	2,886	731,211	255,693	49,433	10,988	3,022	2,421	10,489	.265	.334	.394	.728
19	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
20	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
24	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331
25	Wolverines	87	880	.494	426	437	31,647	4,849	8,116	1,241	537	264	2,412	1,880	84		654		33,611	11,223	2,042					.256	.300	.355	.655