The Cincinnati Reds had the highest run differential by a team in 1976, with a differential of 224 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Reds	224	1976	162	.630	102	60	5,702	857	1,599	271	63	141	802	681	28	902	210	57	6,538	2,419	475	67	60	63	103	.280	.357	.424	.781
2	Phillies	213	1976	162	.623	101	61	5,528	770	1,505	259	45	110	708	542	40	793	127	70	6,236	2,184	414	59	67	55	119	.272	.338	.395	.733
3	Yankees	155	1976	159	.610	97	62	5,555	730	1,496	231	36	120	681	470	35	616	163	65	6,156	2,159	387	50	46	36	94	.269	.328	.389	.716
4	Royals	102	1976	162	.556	90	72	5,540	713	1,490	259	57	65	656	484	31	650	218	106	6,197	2,058	381	71	71	36	103	.269	.327	.371	.699
5	Athletics	88	1976	161	.540	87	74	5,353	686	1,319	208	33	113	625	592	45	818	341	123	6,106	1,932	354	58	58	45	91	.246	.323	.361	.684
6	Pirates	78	1976	162	.568	92	70	5,604	708	1,499	249	56	110	660	433	29	807	130	45	6,177	2,190	415	61	50	56	131	.267	.321	.391	.711
7	Mets	77	1976	162	.531	86	76	5,415	615	1,334	198	34	102	560	561	28	797	66	58	6,129	1,906	334	92	33	53	127	.246	.319	.352	.671
8	Dodgers	65	1976	162	.568	92	70	5,472	608	1,371	200	34	91	561	486	29	744	144	55	6,125	1,912	325	91	47	71	129	.251	.313	.349	.662
9	Red Sox	56	1976	162	.512	83	79	5,511	716	1,448	257	53	134	664	500	29	832	95	70	6,154	2,213	444	55	59	35	127	.263	.324	.402	.726
10	Twins	39	1976	162	.525	85	77	5,574	743	1,526	222	51	81	691	550	41	714	146	75	6,307	2,093	354	93	49	39	121	.274	.341	.375	.716
11	Orioles	21	1976	162	.543	88	74	5,457	619	1,326	213	28	119	576	519	23	883	150	61	6,091	1,952	360	57	35	34	119	.243	.310	.358	.667
12	Indians	0	1976	159	.509	81	78	5,412	615	1,423	189	38	85	567	479	11	631	75	69	6,029	1,943	312	67	60	42	143	.263	.321	.359	.680
13	Astros	-32	1976	162	.494	80	82	5,464	625	1,401	195	50	66	571	530	21	719	150	57	6,111	1,894	311	57	39	54	127	.256	.322	.347	.669
14	Rangers	-36	1976	162	.469	76	86	5,555	616	1,390	213	26	80	574	568	29	809	87	45	6,269	1,895	319	72	45	46	141	.250	.321	.341	.662
15	Cardinals	-42	1976	162	.444	72	90	5,516	629	1,432	243	57	63	584	512	22	860	123	55	6,181	1,978	363	86	45	69	127	.260	.323	.359	.681
16	Braves	-80	1976	162	.432	70	92	5,345	620	1,309	170	30	82	586	589	19	811	74	61	6,107	1,785	282	107	47	46	131	.245	.320	.334	.653
17	Angels	-81	1976	162	.469	76	86	5,385	550	1,265	210	23	63	511	534	42	812	126	80	6,101	1,710	296	92	48	50	130	.235	.306	.318	.624
18	Brewers	-85	1976	161	.410	66	95	5,396	570	1,326	170	38	88	536	511	23	909	62	61	6,056	1,836	296	78	48	30	112	.246	.311	.340	.651
19	Giants	-91	1976	162	.457	74	88	5,452	595	1,340	211	37	85	552	518	25	778	88	55	6,123	1,880	333	80	48	52	122	.246	.312	.345	.656
20	Padres	-92	1976	162	.451	73	89	5,369	570	1,327	216	37	64	528	488	23	716	92	46	6,047	1,809	317	125	42	57	119	.247	.310	.337	.647
21	Tigers	-100	1976	161	.460	74	87	5,441	609	1,401	207	38	101	566	450	31	730	107	59	6,018	1,987	346	46	50	35	157	.257	.315	.365	.680
22	Cubs	-117	1976	162	.463	75	87	5,519	611	1,386	216	24	105	559	490	30	834	74	74	6,155	1,965	345	75	41	66	126	.251	.313	.356	.670
23	White Sox	-159	1976	161	.398	64	97	5,532	586	1,410	209	46	73	538	471	34	739	120	53	6,171	1,930	328	79	55	43	104	.255	.314	.349	.663
24	Expos	-203	1976	162	.340	55	107	5,428	531	1,275	224	32	94	507	433	16	841	86	44	5,992	1,845	350	75	40	43	107	.235	.291	.340	.631