The Los Angeles Dodgers and the Milwaukee Brewers were tied for the highest run differential in 1978, with a differential of 154 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	154	1978	162	.586	95	67	5,437	727	1,435	251	27	149	686	610	20	818	137	52	6,225	2,187	427	111	47	76	101	.264	.338	.402	.740
2	Brewers	154	1978	162	.574	93	69	5,536	804	1,530	265	38	173	762	520	32	805	95	53	6,227	2,390	476	89	50	38	94	.276	.339	.432	.771
3	Yankees	153	1978	163	.613	100	63	5,583	735	1,489	228	38	125	693	505	42	695	98	42	6,219	2,168	391	37	52	45	126	.267	.329	.388	.718
4	Red Sox	139	1978	163	.607	99	64	5,587	796	1,493	270	46	172	738	582	24	835	74	51	6,316	2,371	488	65	58	43	135	.267	.336	.424	.760
5	Phillies	122	1978	162	.556	90	72	5,448	708	1,404	248	32	133	661	552	42	866	152	58	6,152	2,115	413	61	49	88	93	.258	.328	.388	.716
6	Royals	109	1978	162	.568	92	70	5,474	743	1,469	305	59	98	695	498	30	644	216	84	6,129	2,186	462	55	72	44	95	.268	.329	.399	.728
7	Tigers	61	1978	162	.531	86	76	5,601	714	1,520	218	34	129	666	563	31	695	90	38	6,299	2,193	381	57	47	32	145	.271	.339	.392	.730
8	Rangers	60	1978	162	.537	87	75	5,347	692	1,353	216	36	132	650	624	32	779	196	91	6,141	2,037	384	83	55	45	115	.253	.332	.381	.713
9	Pirates	47	1978	161	.547	88	73	5,406	684	1,390	239	54	115	631	480	42	874	213	90	6,038	2,082	408	64	46	89	95	.257	.320	.385	.705
10	Orioles	26	1978	161	.559	90	71	5,422	659	1,397	248	19	154	612	552	22	864	75	61	6,079	2,145	421	41	42	34	136	.258	.326	.396	.722
11	Angels	25	1978	162	.537	87	75	5,472	691	1,417	226	28	108	646	539	67	682	86	69	6,206	2,023	362	72	56	38	135	.259	.330	.370	.700
12	Reds	22	1978	161	.571	92	69	5,392	710	1,378	270	32	136	669	636	26	899	137	58	6,192	2,120	438	84	54	72	112	.256	.334	.393	.727
13	Expos	22	1978	162	.469	76	86	5,530	633	1,404	269	31	121	589	396	35	881	80	42	6,063	2,098	421	62	40	62	126	.254	.306	.379	.685
14	Giants	19	1978	162	.549	89	73	5,364	613	1,331	240	41	117	576	554	17	814	87	54	6,102	2,004	398	127	40	75	104	.248	.318	.374	.692
15	Padres	-7	1978	162	.519	84	78	5,360	591	1,349	208	42	75	542	536	32	848	152	70	6,081	1,866	325	114	39	87	81	.252	.321	.348	.669
16	Twins	-12	1978	162	.451	73	89	5,522	666	1,472	259	47	82	621	604	33	684	99	56	6,323	2,071	388	109	55	43	139	.267	.339	.375	.714
17	Astros	-29	1978	162	.457	74	88	5,458	605	1,408	231	45	70	557	434	22	743	178	59	6,034	1,939	346	76	44	67	134	.258	.313	.355	.668
18	Indians	-55	1978	159	.434	69	90	5,365	639	1,400	223	45	106	596	488	26	698	64	63	6,011	2,031	374	92	40	31	124	.261	.323	.379	.702
19	Cardinals	-57	1978	162	.426	69	93	5,415	600	1,351	263	44	79	568	420	22	713	97	42	5,965	1,939	386	55	53	55	131	.249	.303	.358	.661
20	Cubs	-60	1978	162	.488	79	83	5,532	664	1,461	224	48	72	612	562	21	746	110	58	6,258	1,997	344	84	59	61	125	.264	.331	.361	.692
21	Mets	-83	1978	162	.407	66	96	5,433	607	1,332	227	47	86	561	549	24	829	100	77	6,132	1,911	360	71	55	59	126	.245	.314	.352	.666
22	White Sox	-97	1978	161	.441	71	90	5,393	634	1,423	221	41	106	595	409	33	625	83	68	5,955	2,044	368	63	57	20	122	.264	.317	.379	.696
23	Braves	-150	1978	162	.426	69	93	5,381	600	1,313	191	39	123	558	550	27	874	90	65	6,066	1,951	353	61	47	53	140	.244	.315	.363	.677
24	Athletics	-158	1978	162	.426	69	93	5,321	532	1,304	200	31	100	492	433	25	800	144	117	5,914	1,866	331	108	27	33	106	.245	.303	.351	.654
25	Blue Jays	-185	1978	161	.366	59	102	5,430	590	1,358	217	39	98	551	448	23	645	28	52	6,015	1,947	354	77	37	23	124	.250	.308	.359	.667