The Milwaukee Brewers had the highest run differential by a team in 1992, with a differential of 136 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Brewers	136	1992	162	.568	92	70	5,504	740	1,477	272	35	82	683	511	33	779	256	115	6,181	2,065	389	61	72	45	102	.268	.330	.375	.705
2	Braves	113	1992	162	.605	98	64	5,480	682	1,391	223	48	138	641	493	26	924	126	60	6,142	2,124	409	93	50	58	82	.254	.316	.388	.703
3	Pirates	98	1992	162	.593	96	66	5,527	693	1,409	272	54	106	656	569	25	872	110	53	6,266	2,107	432	89	56	88	102	.255	.324	.381	.705
4	Blue Jays	98	1992	162	.593	96	66	5,536	780	1,458	265	40	163	737	561	47	933	129	39	6,224	2,292	468	26	54	41	123	.263	.333	.414	.747
5	Twins	94	1992	162	.556	90	72	5,582	747	1,544	275	27	104	701	527	53	834	123	74	6,267	2,185	406	46	59	53	130	.277	.341	.391	.733
6	Athletics	73	1992	162	.593	96	66	5,387	745	1,389	219	24	142	693	707	49	831	143	59	6,274	2,082	385	72	59	46	139	.258	.346	.386	.732
7	Expos	67	1992	162	.537	87	75	5,477	648	1,381	263	37	102	601	463	43	976	196	63	6,120	2,024	402	82	55	43	104	.252	.313	.370	.682
8	Reds	51	1992	162	.556	90	72	5,460	660	1,418	281	44	99	606	563	21	888	125	65	6,162	2,084	424	66	52	83	123	.260	.328	.382	.710
9	Orioles	49	1992	162	.549	89	73	5,485	705	1,423	243	36	148	680	647	51	827	89	48	6,292	2,182	427	50	59	55	139	.259	.340	.398	.738
10	White Sox	48	1992	162	.531	86	76	5,498	738	1,434	269	36	110	686	622	31	784	160	57	6,267	2,105	415	47	69	48	134	.261	.336	.383	.718
11	Cardinals	27	1992	162	.512	83	79	5,594	631	1,464	262	44	94	599	495	32	996	208	118	6,230	2,096	400	68	41	49	96	.262	.323	.375	.698
12	Tigers	-3	1992	162	.463	75	87	5,515	791	1,411	256	16	182	746	675	24	1,055	66	45	6,310	2,245	454	43	53	42	124	.256	.337	.407	.744
13	Yankees	-13	1992	162	.469	76	86	5,593	733	1,462	281	18	163	703	536	42	903	78	37	6,252	2,268	462	26	55	51	138	.261	.328	.406	.733
14	Padres	-19	1992	162	.506	82	80	5,476	617	1,396	255	30	135	576	453	26	864	69	52	6,074	2,116	420	78	41	67	126	.255	.313	.386	.699
15	Cubs	-31	1992	162	.481	78	84	5,590	593	1,420	221	41	104	566	417	31	816	77	51	6,156	2,035	366	78	40	49	121	.254	.307	.364	.671
16	Phillies	-31	1992	162	.432	70	92	5,500	686	1,392	255	36	118	638	509	52	1,059	127	31	6,171	2,073	409	64	46	45	111	.253	.320	.377	.697
17	Mets	-54	1992	162	.444	72	90	5,340	599	1,254	259	17	93	564	572	28	956	129	52	6,059	1,826	369	74	45	53	117	.235	.310	.342	.652
18	Royals	-57	1992	162	.444	72	90	5,501	610	1,411	284	42	75	568	439	51	741	131	71	6,082	2,004	401	45	46	30	121	.256	.315	.364	.679
19	Astros	-60	1992	162	.500	81	81	5,480	608	1,350	255	38	96	582	506	48	1,025	139	54	6,162	1,969	389	88	40	65	97	.246	.313	.359	.673
20	Red Sox	-70	1992	162	.451	73	89	5,461	599	1,343	259	21	84	567	591	31	865	44	48	6,186	1,896	364	60	43	46	118	.246	.321	.347	.668
21	Rangers	-71	1992	162	.475	77	85	5,537	682	1,387	266	23	159	646	550	50	1,036	81	44	6,238	2,176	448	56	45	36	115	.250	.321	.393	.714
22	Indians	-72	1992	162	.469	76	86	5,620	674	1,495	227	24	127	637	448	45	885	144	67	6,199	2,151	378	42	44	46	140	.266	.323	.383	.706
23	Giants	-73	1992	162	.444	72	90	5,456	574	1,330	220	36	105	532	435	39	1,067	112	64	6,070	1,937	361	101	39	53	111	.244	.302	.355	.657
24	Dodgers	-88	1992	162	.389	63	99	5,368	548	1,333	201	34	72	499	503	24	899	142	78	6,037	1,818	307	102	40	36	111	.248	.313	.339	.652
25	Angels	-92	1992	162	.444	72	90	5,364	579	1,306	202	20	88	537	416	40	882	160	101	5,916	1,812	310	56	40	40	137	.243	.301	.338	.638