The Cleveland Indians had the highest run differential by a team in 1996, with a differential of 183 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Indians	183	1996	161	.615	99	62	5,681	952	1,665	335	23	218	904	671	43	844	160	50	6,486	2,700	576	34	57	44	164	.293	.369	.475	.844
2	Rangers	129	1996	163	.556	90	72	5,702	928	1,622	323	32	221	890	660	31	1,041	83	26	6,494	2,672	576	32	69	51	128	.284	.358	.469	.827
3	Braves	125	1996	162	.593	96	66	5,614	773	1,514	264	28	197	735	530	27	1,032	83	43	6,290	2,425	489	69	50	41	144	.270	.333	.432	.765
4	White Sox	104	1996	162	.525	85	77	5,644	898	1,586	284	33	195	860	701	34	927	105	41	6,497	2,521	512	56	62	68	139	.281	.360	.447	.807
5	Mariners	98	1996	161	.528	85	76	5,668	993	1,625	343	19	245	954	670	75	1,052	90	39	6,517	2,741	607	46	58	57	121	.287	.366	.484	.850
6	Padres	89	1996	162	.562	91	71	5,655	771	1,499	285	24	147	718	601	50	1,014	109	55	6,417	2,273	456	59	52	62	146	.265	.338	.402	.740
7	Yankees	84	1996	162	.568	92	70	5,628	871	1,621	293	28	162	830	632	41	909	96	46	6,414	2,456	483	41	72	56	153	.288	.360	.436	.796
8	Expos	73	1996	162	.543	88	74	5,505	741	1,441	297	27	148	696	492	58	1,077	108	34	6,170	2,236	472	79	36	49	119	.262	.327	.406	.733
9	Cardinals	53	1996	162	.543	88	74	5,502	759	1,468	281	31	142	711	495	44	1,089	149	58	6,177	2,237	454	88	48	59	121	.267	.330	.407	.736
10	Dodgers	51	1996	162	.556	90	72	5,538	703	1,396	215	33	150	661	516	22	1,190	124	40	6,185	2,127	398	74	35	59	112	.252	.316	.384	.701
11	Orioles	46	1996	163	.543	88	74	5,689	949	1,557	299	29	257	914	645	61	915	76	40	6,493	2,685	585	31	67	49	134	.274	.350	.472	.822
12	Red Sox	7	1996	162	.525	85	77	5,756	928	1,631	308	31	209	882	642	67	1,020	91	44	6,545	2,628	548	33	47	50	148	.283	.359	.457	.816
13	Reds	5	1996	162	.500	81	81	5,455	778	1,398	259	36	191	733	604	34	1,134	171	63	6,213	2,302	486	71	49	47	115	.256	.331	.422	.753
14	Cubs	1	1996	162	.469	76	86	5,531	772	1,388	267	19	175	725	523	61	1,090	108	50	6,229	2,218	461	66	48	48	126	.251	.320	.401	.721
15	Rockies	-3	1996	162	.512	83	79	5,590	961	1,607	297	37	221	909	527	82	1,108	201	66	6,332	2,641	555	81	52	40	118	.287	.355	.472	.827
16	Brewers	-5	1996	162	.494	80	82	5,662	894	1,578	304	40	178	845	624	53	986	101	48	6,434	2,496	522	45	50	35	115	.279	.353	.441	.794
17	Marlins	-15	1996	162	.494	80	82	5,498	688	1,413	240	30	150	650	553	55	1,122	99	46	6,192	2,163	420	41	45	51	138	.257	.329	.393	.722
18	Twins	-23	1996	162	.481	78	84	5,673	877	1,633	332	47	118	812	576	65	958	143	53	6,397	2,413	497	20	63	42	172	.288	.357	.425	.782
19	Mets	-33	1996	162	.438	71	91	5,618	746	1,515	267	47	147	697	445	33	1,069	97	48	6,220	2,317	461	75	49	54	114	.270	.324	.412	.737
20	Athletics	-39	1996	162	.481	78	84	5,630	861	1,492	283	21	243	823	640	58	1,114	58	35	6,402	2,546	547	35	39	36	134	.265	.344	.452	.796
21	Astros	-39	1996	162	.506	82	80	5,508	753	1,445	297	29	129	703	554	84	1,057	180	63	6,269	2,187	455	68	55	64	115	.262	.336	.397	.733
22	Royals	-40	1996	161	.466	75	86	5,542	746	1,477	286	38	123	689	529	43	943	195	85	6,229	2,208	447	66	49	36	102	.267	.332	.398	.731
23	Blue Jays	-43	1996	162	.457	74	88	5,599	766	1,451	302	35	177	712	529	92	1,105	116	38	6,295	2,354	514	38	37	19	120	.259	.331	.420	.752
24	Pirates	-57	1996	162	.451	73	89	5,665	776	1,509	319	33	138	738	510	40	989	126	49	6,336	2,308	490	72	49	46	107	.266	.329	.407	.736
25	Giants	-110	1996	162	.420	68	94	5,533	752	1,400	245	21	153	707	615	48	1,189	113	53	6,316	2,146	419	77	43	62	108	.253	.331	.388	.719