Between the 2020 and 2022 seasons, the Los Angeles Dodgers had the highest run differential by a team, with a differential of 739 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	739	384	.677	260	124	13,013	2,026	3,271	669	61	567	1,938	1,448	190	3,253	192	43	14,799	5,763	1,297	38	110	65	227	.251	.333	.443	.775
2	Astros	428	384	.599	230	154	12,994	1,879	3,315	686	39	504	1,817	1,289	147	2,841	158	49	14,563	5,591	1,229	24	109	48	293	.255	.327	.430	.757
3	Braves	374	383	.585	224	159	12,946	1,927	3,257	697	34	585	1,853	1,258	156	3,524	169	54	14,480	5,777	1,316	34	86	62	223	.252	.323	.446	.770
4	Yankees	327	384	.583	224	160	12,668	1,833	3,047	525	27	570	1,731	1,492	163	3,353	192	58	14,434	5,336	1,122	25	86	55	326	.241	.326	.421	.748
5	Rays	318	384	.589	226	158	12,894	1,812	3,100	689	65	441	1,718	1,328	157	3,545	231	88	14,478	5,242	1,195	13	86	49	206	.240	.317	.407	.724
6	Blue Jays	269	384	.560	215	169	13,054	1,923	3,435	696	29	550	1,860	1,199	118	2,968	181	61	14,479	5,839	1,275	26	82	31	287	.263	.329	.447	.776
7	Giants	231	384	.565	217	167	12,873	1,819	3,153	633	57	505	1,741	1,368	186	3,422	149	38	14,569	5,415	1,195	46	96	67	277	.245	.324	.421	.745
8	White Sox	189	384	.544	209	175	13,015	1,788	3,342	641	37	435	1,705	1,153	175	3,229	135	38	14,471	5,362	1,113	41	87	20	310	.257	.324	.412	.736
9	Cardinals	180	382	.558	213	169	12,599	1,718	3,099	624	50	446	1,648	1,220	199	3,044	202	57	14,172	5,161	1,120	49	105	46	249	.246	.320	.410	.730
10	Padres	150	384	.534	205	179	12,824	1,759	3,128	651	51	428	1,689	1,364	154	3,130	214	74	14,513	5,165	1,130	65	106	72	253	.244	.322	.403	.724
11	Brewers	135	384	.547	210	174	12,699	1,710	2,951	589	40	488	1,641	1,384	203	3,511	193	62	14,404	5,084	1,117	36	82	59	272	.232	.316	.400	.716
12	Mets	112	384	.531	204	180	12,722	1,694	3,216	606	52	433	1,617	1,202	251	3,107	136	58	14,310	5,225	1,091	55	80	58	298	.253	.328	.411	.738
13	Guardians	93	384	.539	207	177	12,849	1,663	3,125	617	58	389	1,582	1,142	169	3,026	253	54	14,313	5,025	1,064	49	104	58	260	.243	.311	.391	.702
14	Phillies	46	384	.513	197	187	12,810	1,787	3,180	607	63	485	1,708	1,271	147	3,245	217	55	14,386	5,368	1,155	61	97	68	259	.248	.321	.419	.740
15	Red Sox	-31	384	.505	194	190	13,117	1,856	3,413	800	42	455	1,765	1,177	145	3,304	123	50	14,566	5,662	1,297	26	101	53	282	.260	.326	.432	.757
16	Mariners	-33	384	.539	207	177	12,659	1,641	2,880	550	35	456	1,580	1,338	191	3,434	197	67	14,302	4,868	1,041	21	93	30	247	.228	.309	.385	.693
17	Twins	-39	384	.487	187	197	12,844	1,694	3,135	621	38	497	1,616	1,229	161	3,286	106	39	14,355	5,323	1,156	19	102	37	293	.244	.316	.414	.730
18	Athletics	-104	384	.474	182	202	12,617	1,585	2,861	611	45	407	1,499	1,216	196	3,262	192	46	14,166	4,783	1,063	41	96	29	252	.227	.303	.379	.682
19	Reds	-141	384	.458	176	208	12,645	1,677	3,006	606	34	468	1,611	1,244	230	3,389	123	66	14,251	5,084	1,108	47	85	32	300	.238	.315	.402	.717
20	Angels	-153	384	.458	176	208	12,880	1,640	3,097	581	62	465	1,576	1,152	138	3,423	177	61	14,299	5,197	1,108	61	68	71	251	.240	.308	.403	.712
21	Cubs	-183	384	.466	179	205	12,649	1,627	2,970	572	65	443	1,540	1,238	228	3,612	221	84	14,254	5,001	1,080	60	79	42	305	.235	.313	.395	.708
22	Marlins	-209	384	.435	167	217	12,678	1,472	2,957	556	48	362	1,395	1,077	160	3,519	279	72	14,030	4,695	966	40	75	37	252	.233	.300	.370	.670
23	Diamondbacks	-278	384	.393	151	233	12,837	1,650	3,011	671	67	375	1,557	1,249	150	3,267	170	52	14,401	4,941	1,113	64	101	43	233	.235	.308	.385	.692
24	Tigers	-284	382	.435	166	216	12,647	1,503	3,002	549	76	351	1,447	1,017	121	3,494	154	55	13,921	4,756	976	28	108	17	263	.237	.298	.376	.674
25	Royals	-296	384	.430	165	219	12,852	1,574	3,161	595	74	369	1,497	1,053	121	3,072	277	87	14,191	5,011	1,038	59	106	18	229	.246	.307	.390	.697