The Chicago Cubs have the highest run differential by a team in their last 81 games, with a differential of 136 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	136	81	.605	49	32	2,814	466	742	138	19	107	450	306	25	630	94	16	3,178	1,239	264	10	23	10	41	.264	.339	.440	.779
2	Dodgers	109	81	.679	55	26	2,733	471	716	118	14	136	451	321	32	641	83	10	3,124	1,270	268	7	31	14	51	.262	.343	.465	.808
3	Mets	97	81	.642	52	29	2,701	385	660	122	13	96	369	272	53	678	45	9	3,057	1,096	231	1	30	12	55	.244	.322	.406	.728
4	Tigers	95	81	.642	52	29	2,721	358	665	124	17	83	347	286	25	790	36	11	3,056	1,072	224	5	19	8	44	.244	.320	.394	.714
5	Yankees	86	81	.568	46	35	2,720	410	669	124	5	120	389	341	35	724	70	20	3,123	1,163	249	4	23	19	59	.246	.335	.428	.763
6	Mariners	81	81	.568	46	35	2,709	396	656	120	3	104	377	330	67	748	90	21	3,144	1,094	227	13	25	9	54	.242	.336	.404	.740
7	Padres	66	81	.630	51	30	2,692	348	688	128	9	93	325	243	22	538	65	16	2,993	1,113	230	16	20	9	53	.256	.320	.413	.734
8	Astros	56	81	.568	46	35	2,753	352	704	119	7	90	328	245	30	640	47	12	3,060	1,107	216	9	23	19	70	.256	.321	.402	.723
9	Braves	53	81	.531	43	38	2,760	355	679	124	6	107	341	271	26	701	41	9	3,074	1,136	237	4	13	4	58	.246	.318	.412	.730
10	Diamondbacks	52	81	.543	44	37	2,760	462	727	143	14	120	441	316	42	643	72	19	3,169	1,258	277	18	33	6	57	.263	.344	.456	.800
11	Giants	37	81	.543	44	37	2,693	344	609	126	13	91	327	244	21	757	50	13	2,983	1,034	230	7	18	5	51	.226	.294	.384	.678
12	Brewers	31	81	.531	43	38	2,685	377	627	115	18	83	349	283	26	711	111	22	3,031	1,027	216	15	22	14	47	.234	.310	.382	.693
13	Phillies	22	81	.568	46	35	2,728	374	694	143	12	87	354	262	33	674	67	13	3,045	1,122	242	8	14	8	63	.254	.326	.411	.737
14	Royals	3	81	.506	41	40	2,684	282	619	125	9	58	274	218	27	631	64	21	2,968	936	192	10	29	11	42	.231	.292	.349	.641
15	Reds	-3	81	.481	39	42	2,690	357	644	118	10	77	343	271	38	711	80	24	3,024	1,013	205	7	18	5	47	.239	.316	.377	.692
16	Red Sox	-4	81	.469	38	43	2,748	354	663	143	7	88	341	260	34	770	74	19	3,062	1,084	238	2	18	17	61	.241	.313	.394	.707
17	Cardinals	-4	81	.481	39	42	2,777	350	706	158	8	77	334	269	22	627	55	17	3,093	1,111	243	5	20	13	63	.254	.323	.400	.723
18	Rays	-13	81	.457	37	44	2,691	276	612	112	13	66	260	221	23	723	95	17	2,955	948	191	1	19	9	40	.227	.290	.352	.642
19	Guardians	-20	81	.531	43	38	2,664	310	620	115	5	90	297	249	32	657	70	21	2,982	1,015	210	11	26	15	41	.233	.303	.381	.684
20	Blue Jays	-22	81	.457	37	44	2,729	315	662	138	13	75	302	251	42	613	35	13	3,050	1,051	226	8	20	12	57	.243	.314	.385	.699
21	Twins	-50	81	.383	31	50	2,719	308	632	139	9	70	294	217	43	655	27	12	3,003	999	218	4	20	6	47	.232	.297	.367	.665
22	Orioles	-55	81	.444	36	45	2,701	325	624	101	11	96	307	244	32	709	46	11	3,000	1,035	208	1	22	5	42	.231	.300	.383	.683
23	Rangers	-57	81	.494	40	41	2,700	303	631	115	4	82	289	209	26	665	66	16	2,951	1,000	201	2	14	4	45	.234	.294	.370	.664
24	Athletics	-71	81	.494	40	41	2,760	322	679	126	9	93	310	237	15	680	43	10	3,041	1,102	228	7	22	2	64	.246	.307	.399	.706
25	Nationals	-79	81	.420	34	47	2,687	316	649	121	8	76	295	222	27	616	101	30	2,969	1,014	205	16	17	1	51	.242	.304	.377	.681