Since 2021, the Los Angeles Dodgers have the highest run differential by a team, with a differential of 1,042 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	1,042	722	.637	460	262	24,551	3,838	6,266	1,292	113	1,046	3,700	2,745	335	6,082	448	95	27,930	10,922	2,451	53	246	137	434	.255	.335	.445	.780
2	Astros	691	720	.585	421	299	24,532	3,473	6,347	1,235	72	922	3,341	2,305	296	5,375	379	110	27,388	10,492	2,229	53	202	94	572	.259	.327	.428	.755
3	Braves	660	719	.577	415	304	24,389	3,530	6,174	1,231	76	1,080	3,392	2,289	280	6,315	384	109	27,187	10,797	2,387	51	178	88	478	.253	.322	.443	.765
4	Yankees	501	721	.567	409	312	23,996	3,378	5,754	1,028	61	1,043	3,220	2,760	261	6,272	407	126	27,260	10,033	2,132	50	193	114	580	.240	.322	.418	.741
5	Rays	462	722	.562	406	316	24,306	3,332	5,933	1,228	106	816	3,163	2,322	326	6,464	621	196	27,151	9,821	2,150	35	162	65	412	.244	.316	.404	.721
6	Brewers	388	722	.561	405	317	24,091	3,287	5,752	1,114	92	821	3,135	2,602	303	6,413	614	143	27,233	9,513	2,027	74	163	93	496	.239	.319	.395	.714
7	Padres	281	720	.531	382	338	24,179	3,250	5,991	1,186	81	790	3,102	2,500	258	5,551	471	135	27,247	9,709	2,057	120	190	108	531	.248	.323	.402	.724
8	Phillies	278	722	.551	398	324	24,458	3,407	6,168	1,209	117	900	3,270	2,357	278	6,194	535	117	27,364	10,311	2,226	86	185	104	480	.252	.323	.422	.744
9	Blue Jays	278	721	.535	386	335	24,465	3,353	6,278	1,292	73	880	3,220	2,293	280	5,495	357	117	27,259	10,356	2,245	52	169	72	558	.257	.325	.423	.749
10	Mets	267	722	.536	387	335	24,042	3,225	5,905	1,120	94	862	3,089	2,315	453	5,894	399	95	27,061	9,799	2,076	86	165	86	519	.246	.322	.408	.729
11	Giants	222	721	.538	388	333	24,130	3,198	5,756	1,158	98	845	3,059	2,471	318	6,486	297	83	27,192	9,645	2,101	82	191	99	503	.239	.315	.400	.715
12	Mariners	186	721	.541	390	331	24,044	3,138	5,573	1,070	59	882	3,012	2,515	425	6,766	480	129	27,198	9,407	2,011	47	167	59	456	.232	.314	.391	.705
13	Guardians	81	718	.524	376	342	24,023	3,058	5,855	1,157	107	712	2,898	2,062	314	5,423	583	142	26,680	9,362	1,976	81	200	134	485	.244	.309	.390	.699
14	Cubs	62	721	.494	356	365	24,204	3,307	5,908	1,145	131	834	3,156	2,380	341	6,376	570	153	27,204	9,817	2,110	97	182	72	479	.244	.318	.406	.724
15	Red Sox	46	724	.508	368	356	24,794	3,445	6,353	1,473	95	842	3,288	2,229	304	6,405	411	126	27,555	10,542	2,410	46	182	105	501	.256	.323	.425	.748
16	Cardinals	40	721	.520	375	346	24,347	3,209	6,065	1,199	80	837	3,075	2,296	331	5,778	417	118	27,251	9,935	2,116	84	193	80	479	.249	.320	.408	.728
17	Twins	39	720	.494	356	364	24,308	3,245	5,940	1,226	90	898	3,093	2,319	370	6,320	279	87	27,219	10,040	2,214	40	182	60	537	.244	.317	.413	.731
18	Rangers	-94	721	.460	332	389	24,338	3,162	5,879	1,093	83	850	3,022	2,179	240	6,120	472	131	26,967	9,688	2,026	45	165	65	430	.242	.308	.398	.706
19	Reds	-132	721	.474	342	379	24,081	3,257	5,823	1,177	104	832	3,112	2,316	399	6,452	552	172	27,054	9,704	2,113	90	168	50	487	.242	.317	.403	.720
20	Tigers	-170	722	.490	354	368	24,179	2,955	5,735	1,077	154	705	2,840	2,091	233	6,508	323	102	26,735	9,235	1,936	48	184	45	460	.237	.302	.382	.684
21	Orioles	-174	721	.497	358	363	24,344	3,219	5,953	1,218	110	870	3,084	2,131	288	6,217	414	118	27,005	10,001	2,198	55	187	57	444	.245	.311	.411	.721
22	Diamondbacks	-182	721	.465	335	386	24,266	3,379	5,961	1,245	152	796	3,211	2,443	290	5,889	485	117	27,364	9,898	2,193	145	220	75	478	.246	.319	.408	.727
23	Royals	-387	721	.438	316	405	24,168	2,980	5,955	1,138	159	683	2,861	1,891	250	5,605	582	169	26,644	9,460	1,980	104	231	59	429	.246	.305	.391	.696
24	Angels	-434	721	.447	322	399	24,135	3,020	5,718	1,055	103	878	2,884	2,098	312	6,582	396	148	26,775	9,613	2,036	82	148	103	478	.237	.304	.398	.703
25	White Sox	-449	721	.415	299	422	24,236	2,880	5,832	1,150	57	698	2,753	1,981	260	6,118	342	100	26,711	9,190	1,905	84	150	49	545	.241	.303	.379	.682