Since 1945, the New York Yankees have the highest run differential by a team, with a differential of 8,482 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	8,482	12,643	.571	7,208	5,416	431,642	60,835	113,435	19,331	2,554	13,583	57,599	45,903	3,354	71,275	6,514	2,800	487,995	178,623	35,468	3,812	3,284	2,832	9,990	.263	.336	.414	.750
2	Dodgers	6,728	12,667	.557	7,049	5,600	430,345	56,450	111,265	18,668	2,710	11,544	52,989	43,317	3,064	74,379	8,437	3,550	485,987	169,985	32,922	6,201	3,060	3,733	9,280	.259	.329	.395	.724
3	Red Sox	4,174	12,657	.532	6,727	5,915	435,911	61,358	116,781	22,808	2,598	12,596	58,062	46,257	3,310	73,300	5,149	2,552	492,533	182,573	38,002	3,716	3,339	2,997	10,832	.268	.340	.419	.759
4	Cardinals	3,402	12,655	.531	6,712	5,918	432,458	56,300	113,733	20,322	3,183	10,031	52,823	41,469	3,201	71,739	8,183	3,616	485,509	170,514	33,536	5,239	3,142	3,775	9,537	.263	.330	.394	.724
5	Braves	3,387	12,649	.526	6,643	5,978	430,741	56,320	111,219	19,350	2,405	12,447	53,121	41,969	2,924	74,347	6,254	3,067	484,187	172,720	34,202	5,673	2,880	3,655	9,731	.258	.326	.401	.727
6	Giants	1,844	12,659	.517	6,532	6,114	430,596	55,602	109,936	18,851	2,957	11,875	52,204	42,309	3,163	75,454	6,406	3,145	484,611	170,326	33,683	5,528	3,015	4,018	9,372	.255	.324	.396	.720
7	Guardians	1,267	12,633	.510	6,435	6,178	430,663	56,835	111,916	19,660	2,391	11,920	53,619	42,495	3,320	72,036	6,971	3,388	484,330	172,118	33,971	4,498	3,354	2,545	9,859	.260	.329	.400	.728
8	Astros	727	10,026	.502	5,034	4,987	340,240	42,755	86,730	15,906	2,172	8,422	40,238	32,356	2,898	62,914	7,148	3,135	382,237	132,246	26,500	4,030	2,713	3,144	7,408	.255	.323	.389	.711
9	Blue Jays	358	7,598	.498	3,783	3,812	260,321	35,118	67,699	13,530	1,491	8,256	33,311	24,137	2,423	48,968	4,573	1,963	290,506	108,979	23,277	1,500	2,125	1,401	5,927	.260	.326	.419	.745
10	Reds	-20	12,652	.503	6,357	6,279	430,950	55,978	110,781	20,226	2,596	11,999	52,688	41,685	3,317	78,575	8,418	3,405	484,308	172,196	34,821	5,319	3,037	3,646	9,052	.257	.325	.400	.725
11	White Sox	-118	12,656	.497	6,279	6,348	429,935	55,229	111,055	18,804	2,752	10,862	52,045	40,939	3,656	70,755	7,422	3,482	482,559	167,949	32,418	4,809	3,220	2,461	9,836	.258	.326	.391	.716
12	Diamondbacks	-278	4,320	.489	2,113	2,207	147,394	19,757	37,560	7,716	1,066	4,612	18,825	14,366	1,423	32,611	2,507	902	165,714	61,244	13,394	1,325	1,206	1,090	3,083	.255	.325	.416	.740
13	Rays	-484	4,317	.489	2,112	2,205	146,776	19,168	37,240	7,419	850	4,492	18,235	13,959	1,673	33,415	3,210	1,225	164,301	59,835	12,761	737	1,156	685	3,025	.254	.323	.408	.731
14	Angels	-716	10,185	.495	5,042	5,140	345,558	44,069	88,409	15,284	1,810	9,216	41,467	32,316	2,823	62,735	6,044	3,100	387,004	134,961	26,310	3,537	2,770	2,483	7,877	.256	.322	.391	.713
15	Mets	-775	10,020	.484	4,845	5,167	338,998	41,339	84,706	15,134	1,817	8,578	38,924	32,411	2,858	64,956	5,886	2,734	380,874	129,208	25,529	3,988	2,619	3,137	7,461	.250	.318	.381	.699
16	Brewers	-820	8,890	.487	4,331	4,555	301,753	39,508	77,256	14,401	1,756	8,702	37,430	29,040	2,710	58,920	5,984	2,731	339,080	121,275	24,859	3,162	2,415	2,158	6,609	.256	.325	.402	.726
17	Tigers	-971	12,665	.495	6,252	6,388	432,047	56,847	111,702	19,147	3,007	12,305	53,709	43,146	3,024	74,816	5,549	2,937	485,451	173,778	34,459	4,126	3,108	2,447	9,928	.259	.328	.402	.730
18	Phillies	-1,267	12,654	.493	6,225	6,412	430,536	54,441	109,795	19,735	3,163	10,892	51,143	42,209	3,251	78,399	7,166	2,914	484,070	168,532	33,790	5,060	3,014	3,739	9,110	.255	.324	.391	.716
19	Nationals	-1,478	8,886	.483	4,286	4,596	300,537	37,227	76,257	14,710	1,789	7,605	34,989	28,256	2,626	57,187	6,549	2,776	337,584	117,360	24,104	3,879	2,286	2,881	6,501	.254	.321	.391	.712
20	Orioles	-1,582	12,637	.493	6,219	6,397	430,006	54,979	109,768	19,422	2,182	12,197	51,962	42,562	3,132	73,901	5,805	2,782	483,042	170,145	33,801	4,241	3,101	2,575	10,189	.255	.325	.396	.720
21	Mariners	-1,632	7,597	.477	3,626	3,969	259,147	33,739	66,588	12,416	1,258	7,728	32,052	24,569	2,350	49,722	5,021	2,169	290,089	104,704	21,402	1,947	2,076	1,664	5,678	.257	.325	.404	.729
22	Rockies	-1,898	5,067	.460	2,329	2,738	174,021	25,066	47,012	9,284	1,308	5,728	23,836	15,984	1,581	37,714	3,054	1,366	194,946	76,096	16,320	2,003	1,357	1,209	3,864	.270	.335	.437	.772
23	Twins	-1,971	12,655	.483	6,108	6,527	432,347	55,978	112,466	20,112	3,082	10,535	52,661	41,757	3,413	72,407	6,108	3,079	484,703	170,347	33,729	4,021	3,165	2,663	10,341	.260	.328	.394	.722
24	Athletics	-2,060	12,658	.484	6,120	6,518	428,425	55,140	107,648	18,968	2,471	11,422	51,811	44,349	3,275	75,393	7,497	3,207	483,413	165,824	32,861	4,261	3,103	2,269	9,824	.251	.324	.387	.711
25	Rangers	-2,081	10,174	.476	4,843	5,325	347,305	45,776	89,579	15,964	1,891	10,197	43,254	32,890	2,699	65,167	5,944	2,846	388,689	139,916	28,052	2,963	2,832	2,250	7,795	.258	.324	.403	.727