Since 1970, the New York Yankees have the highest run differential by a team, with a differential of 5,054 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	5,054	8,715	.564	4,909	3,802	298,215	42,479	79,031	14,161	1,367	9,861	40,392	31,497	2,618	52,868	5,247	2,156	336,851	125,509	25,389	1,878	2,643	2,116	7,182	.265	.338	.421	.759
2	Dodgers	4,418	8,727	.550	4,800	3,924	296,616	38,348	76,506	13,293	1,577	8,284	36,265	28,970	2,309	55,515	6,084	2,567	334,147	117,805	23,154	3,865	2,387	2,875	6,325	.258	.326	.397	.724
3	Red Sox	3,510	8,721	.539	4,697	4,023	301,410	43,045	81,630	16,717	1,632	9,216	40,840	30,579	2,650	54,145	4,074	1,958	339,309	129,259	27,565	1,977	2,693	2,323	7,386	.271	.340	.429	.769
4	Cardinals	2,055	8,722	.526	4,587	4,127	296,924	38,853	77,763	14,335	1,927	7,270	36,605	28,769	2,466	54,357	6,689	2,793	334,174	117,762	23,532	3,517	2,498	2,906	6,630	.262	.330	.397	.726
5	Braves	1,718	8,714	.521	4,537	4,171	296,332	38,727	76,232	13,790	1,450	8,811	36,648	29,058	2,179	56,161	4,855	2,435	333,371	119,355	24,051	3,562	2,240	2,700	6,687	.257	.326	.403	.729
6	Astros	1,574	8,726	.513	4,477	4,247	296,716	38,202	76,349	14,339	1,854	7,709	36,043	28,309	2,585	55,629	6,613	2,793	333,433	117,523	23,902	3,398	2,425	2,678	6,440	.257	.325	.396	.721
7	Athletics	828	8,722	.512	4,466	4,256	295,397	39,367	74,410	13,688	1,366	8,915	37,149	30,798	2,562	56,870	6,097	2,561	333,563	117,575	23,969	2,290	2,516	1,741	6,675	.252	.325	.398	.723
8	Mets	584	8,720	.499	4,351	4,366	295,384	36,964	74,498	13,685	1,555	7,762	34,876	28,873	2,537	56,543	5,470	2,383	332,614	114,579	23,002	3,467	2,353	2,781	6,513	.252	.322	.388	.710
9	Giants	374	8,727	.508	4,435	4,291	296,447	37,892	75,454	13,880	1,906	7,871	35,666	29,288	2,308	57,137	5,121	2,489	334,077	116,759	23,657	3,678	2,356	3,143	6,437	.255	.324	.394	.718
10	Blue Jays	359	7,597	.498	3,783	3,811	260,287	35,116	67,692	13,529	1,491	8,256	33,309	24,133	2,423	48,958	4,572	1,963	290,468	108,971	23,276	1,500	2,125	1,401	5,927	.260	.326	.419	.745
11	Reds	157	8,729	.507	4,426	4,297	296,267	38,927	75,827	14,368	1,647	8,677	36,706	29,686	2,574	59,624	6,913	2,646	334,348	119,520	24,692	3,459	2,362	2,736	6,222	.256	.327	.403	.730
12	Guardians	71	8,704	.499	4,341	4,361	297,445	39,930	78,074	14,440	1,517	8,433	37,745	28,905	2,532	52,963	5,695	2,674	334,005	120,847	24,390	2,467	2,656	1,920	6,919	.262	.330	.406	.737
13	Phillies	-177	8,726	.501	4,372	4,350	297,566	38,525	76,114	14,350	1,993	8,128	36,379	29,493	2,514	58,738	5,873	2,206	335,083	118,834	24,471	3,128	2,382	2,890	6,157	.256	.326	.399	.725
14	Diamondbacks	-281	4,317	.489	2,111	2,206	147,287	19,735	37,530	7,710	1,064	4,606	18,805	14,355	1,421	32,592	2,504	902	165,592	61,186	13,380	1,325	1,204	1,090	3,082	.255	.325	.415	.740
15	Angels	-281	8,725	.499	4,354	4,370	296,992	38,721	76,779	13,563	1,499	8,186	36,516	27,718	2,519	53,822	5,526	2,739	332,457	117,898	23,248	2,813	2,415	2,080	6,869	.259	.325	.397	.722
16	Orioles	-331	8,705	.501	4,358	4,343	297,323	39,373	76,826	14,065	1,262	9,405	37,396	28,952	2,481	54,410	4,604	2,116	333,309	121,630	24,732	2,121	2,432	1,900	7,005	.258	.327	.409	.736
17	Rays	-479	4,315	.489	2,112	2,203	146,712	19,164	37,230	7,417	850	4,491	18,231	13,956	1,673	33,396	3,204	1,225	164,234	59,820	12,758	737	1,156	685	3,024	.254	.323	.408	.731
18	Cubs	-636	8,720	.488	4,255	4,457	297,323	38,314	76,189	14,025	1,796	8,501	36,158	28,115	2,423	57,980	4,889	2,384	333,594	119,309	24,322	3,456	2,277	2,669	6,420	.256	.323	.401	.725
19	Brewers	-657	8,724	.489	4,265	4,456	296,218	38,859	75,961	14,218	1,728	8,577	36,837	28,402	2,675	57,881	5,813	2,672	332,769	119,366	24,523	3,089	2,385	2,115	6,498	.256	.325	.403	.728
20	Twins	-852	8,720	.490	4,272	4,445	299,239	39,636	79,138	14,824	1,904	7,736	37,380	27,693	2,575	53,588	4,749	2,390	334,223	120,978	24,464	2,193	2,523	1,990	7,193	.264	.330	.404	.734
21	White Sox	-959	8,719	.488	4,251	4,459	296,806	39,044	77,211	13,678	1,658	8,630	37,008	27,066	2,582	53,994	5,346	2,586	331,557	120,095	23,966	2,596	2,507	1,829	6,787	.260	.325	.405	.729
22	Rangers	-1,010	8,720	.486	4,235	4,480	298,570	40,479	78,150	14,287	1,571	9,032	38,298	28,271	2,443	56,266	5,427	2,536	334,182	122,675	24,890	2,389	2,509	1,909	6,664	.262	.328	.411	.739
23	Nationals	-1,279	8,722	.485	4,232	4,486	295,045	36,625	74,933	14,501	1,755	7,475	34,427	27,724	2,586	56,204	6,495	2,723	331,430	115,369	23,731	3,821	2,254	2,829	6,369	.254	.321	.391	.712
24	Pirates	-1,540	8,715	.483	4,204	4,505	297,026	37,124	76,262	14,420	2,075	7,245	35,092	26,593	2,668	57,145	5,717	2,622	332,171	116,567	23,740	3,427	2,457	2,734	6,248	.257	.321	.392	.713
25	Mariners	-1,644	7,594	.477	3,623	3,969	259,044	33,724	66,566	12,413	1,258	7,724	32,037	24,558	2,350	49,694	5,021	2,168	289,974	104,667	21,395	1,947	2,075	1,664	5,678	.257	.325	.404	.729