The Cleveland Blues have the lowest run differential by a team in a game, with a differential of -31 runs against the Chicago White Stockings on July 24, 1882.
Interpreted as:
MLB lowest negative point differential by a team in a regular-season game| TEAM | DIFF | DATE | TM | OPP | RESULT | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Blues | -31 | 7/24/1882 | CLE | @ |  CWS | L 4-35 | 4 | |||||||||||||||||||||||
| 2 | Colonels | -29 | 6/29/1897 | LOU | @ | CHI | L 7-36 | 7 | |||||||||||||||||||||||
| 3 |  | Quakers | -28 | 6/15/1887 |  PHN | @ |  NYG | L 1-29 | 1 | ||||||||||||||||||||||
| 4 | | Quakers | -28 | 8/21/1883 | PHN | @ | PRO | L 0-28 | 0 | ||||||||||||||||||||||
| 5 |  | Orioles | -27 | 8/22/2007 |  BAL | vs |  TEX | L 3-30 | 35 | 3 | 9 | 2 | 0 | 0 | 2 | 2 | 0 | 4 | 0 | 0 | 37 | 11 | 2 | 0 | 0 | 0 | 1 | .257 | .297 | .314 | .612 |
| 6 |  | Senators | -27 | 9/10/1891 |  WSH | @ |  MIL | L 3-30 | 3 | ||||||||||||||||||||||
| 7 |  | Browns | -25 | 6/8/1950 |  SLA | @ |  BSA | L 4-29 | 33 | 4 | 8 | 1 | 0 | 0 | 4 | 7 | 1 | 5 | 0 | 0 | 41 | 9 | 1 | 0 | 0 | 1 | .242 | .390 | .273 | .663 | |
| 8 | Colonels | -25 | 8/17/1894 | LOU | @ | PHI | L 4-29 | 4 | |||||||||||||||||||||||
| 9 | | Quakers | -25 | 6/20/1883 | PHN | @ |  BSN | L 4-29 | 4 | ||||||||||||||||||||||
| 10 |  | Mutuals | -25 | 5/13/1876 |  NYM | @ | HAR | L 3-28 | 3 | ||||||||||||||||||||||
| 11 |  | Rockies | -24 | 6/24/2023 |  COL | vs |  LAA | L 1-25 | 33 | 1 | 7 | 1 | 1 | 1 | 1 | 0 | 1 | 12 | 0 | 0 | 34 | 13 | 3 | 0 | 0 | 0 | 1 | .212 | .235 | .394 | .629 |
| 12 |  | Red Sox | -24 | 7/7/1923 |  BSA | @ |  CLE | L 3-27 | 39 | 3 | 13 | 1 | 0 | 0 | 3 | 4 | 0 | 1 | 0 | 0 | 43 | 14 | 1 | 0 | .333 | .395 | .359 | .754 | |||
| 13 | Hoosiers | -24 | 6/28/1887 | IND | vs | PHN | L 0-24 | 0 | |||||||||||||||||||||||
| 14 |  | Nationals | -24 | 6/11/1887 |  WSH | @ | NYG | L 2-26 | 2 | ||||||||||||||||||||||
| 15 |  | Orioles | -24 | 6/24/1886 |  BAL | @ |  BKN | L 1-25 | 1 | ||||||||||||||||||||||
| 16 | Bisons | -24 | 5/27/1885 | BUF | @ | NYG | L 0-24 | 0 | |||||||||||||||||||||||
| 17 | Bisons | -24 | 7/3/1883 | BUF | @ | CWS | L 7-31 | 7 | |||||||||||||||||||||||
| 18 | | Red Sox | -23 | 7/22/2022 | BOS | vs |  TOR | L 5-28 | 37 | 5 | 10 | 2 | 0 | 4 | 5 | 0 | 0 | 16 | 0 | 0 | 37 | 24 | 6 | 0 | 0 | 0 | 0 | .270 | .270 | .649 | .919 |
| 19 |  | Athletics | -23 | 4/23/1955 |  KCA | vs |  CWS | L 6-29 | 34 | 6 | 6 | 3 | 0 | 2 | 6 | 4 | 0 | 9 | 0 | 0 | 38 | 15 | 5 | 0 | 0 | 0 | 0 | .176 | .263 | .441 | .704 |
| 20 | | Browns | -23 | 8/12/1948 | SLA | vs | CLE | L 3-26 | 33 | 3 | 7 | 1 | 0 | 0 | 3 | 3 | 0 | 2 | 0 | 0 | 36 | 8 | 1 | 0 | 0 | .212 | .278 | .242 | .520 | ||
| 21 |  | Athletics | -23 | 5/24/1936 |  PHA | vs |  NYY | L 2-25 | 33 | 2 | 7 | 1 | 0 | 0 | 1 | 3 | 0 | 3 | 0 | 0 | 36 | 8 | 1 | 0 | .212 | .278 | .242 | .520 | |||
| 22 |  | Rustlers | -23 | 6/4/1911 |  BSN | @ |  CIN | L 3-26 | 32 | 3 | 8 | 0 | 0 | 0 | 2 | 0 | 4 | 0 | 35 | 8 | 0 | 1 | .250 | .294 | .250 | .544 | |||||
| 23 |  | Browns | -23 | 8/1/1893 |  STL | vs |  PIT | L 2-25 | 2 | ||||||||||||||||||||||
| 24 |  | Grooms | -23 | 8/25/1891 | BKN | @ | CHI | L 5-28 | 5 | ||||||||||||||||||||||
| 25 | | Orioles | -23 | 7/6/1883 | BAL | @ | CIN | L 0-23 | 0 | ||||||||||||||||||||||
Some of the information used here was obtained free of charge from Retrosheet.
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