Willians Astudillo had the fewest strikeouts with 100+ at-bats in 2021, with 12 strikeouts.

Interpreted as:

MLB lowest strikeouts by a player 2021 with 100 or more ab

	NAME	SO	AB	SEASON	TM	G	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	Willians Astudillo W. Astudillo	12	208	2021	MIN	72	17	49	8	0	7	21	3	4	0	0	216	78	15	0	1	0	12	.236	.259	.375	.634	19	-7.5	.272	71	-7.6
2	Nick Senzel N. Senzel	16	111	2021	CIN	36	18	28	4	0	1	8	12	0	2	5	124	35	5	0	1	0	3	.252	.323	.315	.638	12	-2.9	.286	72	-4.4
3	Nick Madrigal N. Madrigal	17	200	2021	CWS	54	30	61	10	4	2	21	11	3	1	2	215	85	16	0	1	0	3	.305	.349	.425	.774	30	3.7	.335	112	3.1
4	Austin Nola A. Nola	19	173	2021	SDP	56	15	47	12	0	2	29	14	5	0	1	194	65	14	0	2	0	2	.272	.340	.376	.716	24	0.2	.316	102	0.4
5	Edward Olivares E. Olivares	19	101	2021	KCR	39	14	24	2	0	5	12	5	3	2	2	111	41	7	1	1	0	2	.238	.291	.406	.697	12	-1.3	.301	86	-1.9
6	Ernie Clement E. Clement	19	121	2021	CLE	40	16	28	4	0	3	9	7	2	0	1	133	41	7	3	0	0	3	.231	.285	.339	.623	12	-4.4	.275	74	-4.2
7	Cam Gallagher C. Gallagher	20	112	2021	KCR	48	9	28	6	0	1	7	8	0	0	0	123	37	7	2	1	0	2	.250	.298	.330	.628	11	-3.9	.276	69	-4.6
8	John Nogowski J. Nogowski	22	129	2021	TOT	52	14	30	7	0	1	14	12	1	0	1	143	40	8	0	1	0	2	.233	.301	.310	.611	12	-4.9	.273	68	-5.9
9	Alejandro Kirk A. Kirk	22	165	2021	TOR	60	19	40	8	0	8	24	19	3	0	0	189	72	16	0	2	0	7	.242	.328	.436	.764	25	2.5	.330	106	1.3
10	Thairo Estrada T. Estrada	23	121	2021	SFG	52	19	33	4	0	7	22	9	2	1	0	132	58	11	0	0	1	2	.273	.333	.479	.813	19	3.5	.346	119	3.3
11	Luis Guillorme L. Guillorme	23	132	2021	NYM	69	13	35	3	0	1	5	23	0	0	2	156	41	4	1	0	2	2	.265	.374	.311	.685	18	-0.5	.311	97	-0.5
12	Max Schrock M. Schrock	24	125	2021	CIN	53	19	36	7	2	3	14	8	0	1	1	134	56	12	0	1	1	0	.288	.328	.448	.776	18	1.6	.329	100	0
13	Nico Hoerner N. Hoerner	25	149	2021	CHC	44	13	45	10	0	0	16	17	3	5	3	170	55	10	0	1	3	3	.302	.382	.369	.751	23	2.1	.330	106	1.3
14	Hanser Alberto H. Alberto	26	241	2021	KCR	103	25	65	20	3	2	24	4	4	3	1	255	97	25	4	2	0	1	.270	.291	.402	.693	27	-3.8	.296	83	-5.4
15	Tommy La Stella T. La Stella	26	220	2021	SFG	76	26	55	11	1	7	27	18	1	0	0	240	89	19	0	1	1	4	.250	.308	.405	.713	28	-1.5	.307	94	-1.8
16	Jose Peraza J. Peraza	26	142	2021	NYM	64	21	29	7	0	6	20	9	3	1	0	154	54	13	0	0	0	5	.204	.266	.380	.647	14	-4.3	.280	78	-4.4
17	Kevin Plawecki K. Plawecki	26	157	2021	BOS	64	15	45	7	0	3	15	12	3	0	0	173	61	10	1	0	0	4	.287	.349	.389	.737	23	1.6	.325	100	0.1
18	Miguel Andujar M. Andujar	28	154	2021	NYY	45	19	39	2	0	6	12	7	0	0	1	162	59	8	0	1	0	8	.253	.284	.383	.667	16	-3.6	.288	83	-3.4
19	Lars Nootbaar L. Nootbaar	28	109	2021	STL	58	15	26	3	1	5	15	13	0	2	1	124	46	9	1	1	1	0	.239	.317	.422	.739	15	0.2	.316	99	-0.1
20	Travis Jankowski T. Jankowski	29	131	2021	PHI	76	24	33	6	2	1	10	22	1	5	0	156	46	9	2	0	4	1	.252	.364	.351	.715	19	-0.3	.312	94	-1.2
21	Taylor Jones T. Jones	29	102	2021	HOU	35	11	25	8	1	2	16	4	0	0	0	108	41	11	0	2	0	5	.245	.269	.402	.670	10	-2.8	.283	79	-2.8
22	Aaron Hicks A. Hicks	30	108	2021	NYY	32	13	21	3	0	4	14	14	2	0	0	126	36	7	0	2	0	3	.194	.294	.333	.627	12	-3.7	.279	77	-3.5
23	Danny Santana D. Santana	30	116	2021	BOS	38	15	21	2	1	5	14	10	1	4	2	127	40	8	0	0	0	0	.181	.252	.345	.597	10	-5.6	.261	57	-6.7
24	Eric Sogard E. Sogard	30	169	2021	CHC	78	16	42	6	1	1	12	9	0	3	1	180	53	8	0	2	1	5	.249	.283	.314	.597	14	-8.2	.259	60	-9.1
25	Santiago Espinal S. Espinal	30	222	2021	TOR	92	32	69	13	1	2	17	22	1	6	1	246	90	16	1	0	0	4	.311	.376	.405	.781	36	6	.344	115	4.5