Nolan Ryan has struck out the most hitters in a decade, with 2,678 strikeouts in the 1970s.

	NAME	SO	DECADE	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Nolan Ryan N. Ryan	2,678	1970s	348	155	146	.515	333	3.14	164	42	2	2465.0	1,731	860	984	133	1,515	75	8	34	10,453	116	9.78	5.53	1.77	0.49	25.6	14.5	1.32	.264	3.59	89	3.05	85	6.32	150.5
2	Randy Johnson R. Johnson	2,538	1990s	298	150	75	.667	290	3.14	65	25	2	2063.1	1,560	721	805	183	910	98	3	13	8,557	65	11.07	3.97	2.79	0.80	29.7	10.6	1.20	.285	3.51	72	3.16	73	6.80	281.4
3	Max Scherzer M. Scherzer	2,452	2010s	319	161	74	.685	319	3.12	10	5	0	2063.2	1,669	716	758	229	534	70	0	17	8,300	58	10.69	2.33	4.59	1.00	29.5	6.4	1.07	.287	3.31	75	3.06	75	7.28	238.9
4	Tom Seaver T. Seaver	2,304	1970s	348	178	101	.638	345	2.61	147	40	0	2652.1	2,105	768	843	190	741	28	2	65	10,607	64	7.82	2.51	3.11	0.64	21.7	7.0	1.07	.261	2.86	73	2.64	74	7.14	272
5	Justin Verlander J. Verlander	2,260	2010s	321	160	86	.650	321	3.10	20	6	0	2142.0	1,738	737	797	228	568	52	0	10	8,635	50	9.50	2.39	3.98	0.96	26.2	6.6	1.08	.273	3.35	75	3.25	78	7.30	218.7
6	Rube Waddell R. Waddell	2,251	1900s	385	183	139	.568	328	2.11	251	49	3	2835.1	2,343	666	1,000	32	772	105	46		11,197	72	7.15	2.45	2.92	0.10	20.1	6.9	1.10	.288	3.17	74	1.98	70	7.44	258.7
7	Walter Johnson W. Johnson	2,219	1910s	454	265	143	.650	361	1.59	327	74	20	3427.2	2,604	606	881	29	661	114	88		13,100	100	5.83	1.74	3.36	0.08	16.9	5.0	0.95	.256	2.31	56	1.96	67	6.84	357.8
8	Tim Keefe T. Keefe	2,219	1880s	490	291	180	.618	487	2.47	470	36	1	4196.0	3,580	1,153	1,948	59	909	41	4		17,162	208	4.76	1.95	2.44	0.13	12.9	5.3	1.07	.253	4.18	77	2.81	87	7.68	196.4
9	Randy Johnson R. Johnson	2,182	2000s	287	143	78	.647	281	3.34	32	12	0	1885.1	1,616	699	790	212	484	89	3	22	7,686	34	10.42	2.31	4.51	1.01	28.4	6.3	1.11	.298	3.77	75	3.12	70	7.71	275.2
10	Clayton Kershaw C. Kershaw	2,179	2010s	294	156	61	.719	293	2.31	25	15	0	1996.0	1,487	513	566	155	434	31	0	20	7,787	70	9.83	1.96	5.02	0.70	28.0	5.6	0.96	.267	2.55	61	2.63	67	6.70	290.2
11	Nolan Ryan N. Ryan	2,167	1980s	314	122	104	.540	314	3.14	44	15	0	2094.0	1,603	730	835	128	894	53	0	34	8,704	123	9.31	3.84	2.42	0.55	24.9	10.3	1.19	.270	3.59	90	2.82	81	6.89	159.5
12	Roger Clemens R. Clemens	2,101	1990s	305	152	89	.631	305	3.02	57	24	0	2177.2	1,829	731	813	139	731	82	0	28	8,968	59	8.68	3.02	2.87	0.57	23.4	8.2	1.18	.286	3.36	66	3.02	68	7.56	333
13	Steve Carlton S. Carlton	2,097	1970s	368	178	126	.586	366	3.18	165	32	0	2747.0	2,413	971	1,103	238	960	31	0	87	11,361	81	6.87	3.15	2.18	0.78	18.5	8.4	1.23	.271	3.61	85	3.26	89	7.91	125.5
14	Bert Blyleven B. Blyleven	2,082	1970s	353	148	128	.536	350	2.88	145	39	0	2624.2	2,335	841	949	186	711	70	2	43	10,722	61	7.14	2.44	2.93	0.64	19.4	6.6	1.16	.280	3.25	78	2.80	76	8.01	260.7
15	Bob Gibson B. Gibson	2,071	1960s	336	164	105	.610	302	2.74	164	41	4	2447.0	1,984	746	847	166	822	75	14	59	10,047	65	7.62	3.02	2.52	0.61	20.6	8.2	1.15	.263	3.12	74	2.81	78	7.30	202.9
16	Jim Bunning J. Bunning	2,019	1960s	378	150	118	.560	360	3.01	108	35	11	2590.1	2,338	867	984	230	621	111	15	67	10,670	31	7.01	2.16	3.25	0.80	18.9	5.8	1.14	.274	3.42	83	2.98	84	8.12	175.3
17	Chris Sale C. Sale	2,007	2010s	312	109	73	.599	232	3.03	16	3	12	1629.2	1,312	548	590	172	374	98	25	14	6,544	38	11.08	2.07	5.37	0.95	30.7	5.7	1.03	.293	3.26	71	2.90	69	7.25	235.7
18	Javier Vazquez J. Vazquez	2,001	2000s	328	128	116	.525	327	3.98	23	6	0	2163.0	2,101	957	1,025	269	528	64	0	40	9,023	59	8.33	2.20	3.79	1.12	22.2	5.9	1.22	.297	4.26	89	3.66	82	8.74	195
19	David Cone D. Cone	1,928	1990s	289	141	85	.624	287	3.21	40	16	0	2017.0	1,667	720	792	169	774	73	1	19	8,378	100	8.60	3.45	2.49	0.75	23.0	9.2	1.21	.276	3.53	76	3.43	80	7.44	185.5
20	Don Drysdale D. Drysdale	1,910	1960s	371	158	126	.556	359	2.83	135	40	4	2629.2	2,341	827	961	207	598	112	10	102	10,718	64	6.54	2.05	3.19	0.71	17.8	5.6	1.12	.270	3.29	84	2.92	89	8.01	100
21	Sandy Koufax S. Koufax	1,910	1960s	260	137	60	.695	237	2.36	122	37	6	1807.2	1,304	474	542	136	512	14	14	36	7,216	57	9.51	2.55	3.73	0.68	26.5	7.1	1.00	.252	2.70	67	2.28	67	6.49	226.4
22	Gaylord Perry G. Perry	1,907	1970s	369	184	133	.580	368	2.92	197	36	1	2905.0	2,559	942	1,088	207	758	51	1	75	11,759	68	5.91	2.35	2.52	0.64	16.2	6.4	1.14	.266	3.37	80	3.02	83	7.93	199.6
23	John Smoltz J. Smoltz	1,893	1990s	315	143	95	.601	315	3.32	42	14	0	2142.1	1,858	791	867	170	669	34	0	49	8,803	109	7.95	2.81	2.83	0.71	21.5	7.6	1.18	.280	3.64	81	3.25	79	7.81	206.5
24	Zack Greinke Z. Greinke	1,872	2010s	311	155	70	.689	311	3.18	7	2	0	1984.0	1,759	702	756	198	442	37	0	14	8,000	65	8.49	2.01	4.24	0.90	23.4	5.5	1.11	.286	3.43	79	3.25	81	7.98	168.5
25	Cole Hamels C. Hamels	1,872	2010s	306	115	87	.569	305	3.33	11	3	0	1958.0	1,742	724	778	214	579	88	0	24	8,072	46	8.60	2.66	3.23	0.98	23.2	7.2	1.19	.287	3.58	81	3.64	89	8.01	97.2