Between the 2016 and 2019 seasons, the Houston Astros had the most wins by a team, with 395 wins.

Interpreted as:

MLB most team regular-season wins from 2016 to 2019

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	395	253	.610	648	22,222	3,337	5,876	1,238	95	929	3,197	2,273	244	4,902	338	139	24,995	10,091	2,262	62	194	94	575	.264	.337	.454	.791
2	Dodgers	393	256	.606	649	21,991	3,185	5,531	1,182	94	924	3,027	2,428	264	5,493	254	88	24,992	9,673	2,200	155	154	166	458	.252	.331	.440	.771
3	Indians	380	267	.587	647	22,015	3,182	5,685	1,224	95	836	3,030	2,252	229	4,920	460	125	24,810	9,607	2,155	119	195	108	470	.258	.331	.436	.767
4	Red Sox	378	270	.583	648	22,732	3,440	6,122	1,345	102	829	3,257	2,288	200	5,019	382	116	25,432	10,158	2,276	44	168	156	535	.269	.339	.447	.786
5	Yankees	378	270	.583	648	22,150	3,332	5,708	1,070	83	997	3,193	2,285	217	5,432	280	87	24,908	9,935	2,150	59	197	80	460	.258	.330	.449	.779
6	Cubs	374	274	.577	649	22,084	3,205	5,642	1,123	119	845	3,057	2,435	339	5,588	239	127	25,172	9,538	2,087	160	154	199	475	.255	.336	.432	.768
7	Nationals	367	281	.566	648	22,072	3,226	5,742	1,161	112	840	3,092	2,293	235	5,176	464	131	24,970	9,647	2,113	180	190	194	439	.260	.334	.437	.771
8	Cardinals	348	300	.537	648	21,965	3,063	5,522	1,077	93	836	2,912	2,205	291	5,466	295	118	24,803	9,293	2,006	170	172	119	458	.251	.325	.423	.749
9	Brewers	344	305	.530	649	21,881	2,926	5,426	1,047	82	886	2,791	2,312	220	6,135	534	154	24,701	9,295	2,015	144	144	142	495	.248	.324	.425	.749
10	Athletics	338	310	.522	648	22,104	3,050	5,487	1,189	79	887	2,920	2,135	239	5,355	191	87	24,671	9,495	2,155	39	154	69	547	.248	.319	.430	.749
11	Rays	334	314	.515	648	22,062	2,851	5,515	1,079	136	811	2,712	2,076	298	5,901	370	159	24,666	9,299	2,026	70	160	90	439	.250	.321	.421	.742
12	Diamondbacks	329	319	.508	648	22,283	3,070	5,586	1,146	185	806	2,921	2,141	226	5,703	407	100	24,951	9,520	2,137	151	150	159	453	.251	.321	.427	.748
13	Braves	327	320	.505	647	22,240	2,995	5,736	1,175	111	711	2,862	2,106	251	5,181	331	129	24,956	9,266	1,997	197	162	209	485	.258	.327	.417	.744
14	Rockies	324	325	.499	649	22,349	3,284	5,974	1,214	168	830	3,149	2,009	178	5,638	291	137	24,900	10,014	2,212	209	155	144	481	.267	.331	.448	.779
15	Twins	323	325	.498	648	22,433	3,214	5,779	1,209	111	879	3,081	2,165	208	5,430	261	108	25,049	9,847	2,199	82	161	96	391	.258	.327	.439	.765
16	Mariners	321	327	.495	648	22,147	2,953	5,589	1,042	94	838	2,823	2,011	278	5,357	339	147	24,671	9,333	1,974	81	154	84	480	.252	.320	.421	.742
17	Mets	320	328	.494	648	22,061	2,873	5,448	1,071	98	854	2,778	2,128	287	5,381	227	107	24,750	9,277	2,023	127	147	144	486	.247	.319	.421	.740
18	Rangers	318	330	.491	648	21,948	3,111	5,454	1,074	92	869	2,963	2,069	306	5,775	417	153	24,575	9,319	2,035	95	157	75	426	.248	.320	.425	.744
19	Angels	306	342	.472	648	21,860	2,917	5,415	1,047	78	776	2,788	2,094	261	4,765	363	120	24,455	8,946	1,901	64	176	118	542	.248	.319	.409	.728
20	Blue Jays	305	343	.471	648	21,948	2,887	5,313	1,135	60	907	2,766	2,182	209	5,590	205	98	24,549	9,289	2,102	70	140	53	531	.242	.315	.423	.738
21	Pirates	304	342	.471	647	22,104	2,847	5,635	1,131	144	624	2,718	1,979	291	4,989	311	148	24,685	8,926	1,899	161	150	157	493	.255	.322	.404	.726
22	Giants	301	347	.465	648	22,236	2,635	5,475	1,125	138	558	2,515	1,962	177	5,213	279	132	24,687	8,550	1,821	130	182	146	480	.246	.310	.385	.695
23	Phillies	298	350	.460	648	21,965	2,751	5,326	1,070	127	736	2,623	2,062	226	5,766	302	114	24,518	8,858	1,933	133	132	138	439	.242	.312	.403	.716
24	White Sox	279	368	.431	647	22,115	2,756	5,615	1,052	130	718	2,641	1,659	261	5,825	309	136	24,300	9,081	1,900	124	141	64	459	.254	.312	.411	.722
25	Reds	278	370	.429	648	21,953	2,866	5,525	1,012	123	782	2,737	2,068	278	5,425	416	161	24,640	9,129	1,917	187	154	138	484	.252	.322	.416	.738