Ed Walsh has struck out the most hitters in a week, with 34 strikeouts the week of September 28, 1908.

	NAME	SO	WEEK	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Ed Walsh E. Walsh	34	9/28/1908 - 10/4/1908	4	2	1	.667	3		3	1	1	28.2	13		3	0	2	2	1		99	1	10.67	0.63	17.00	0.00	34.3	2.0	0.52	.213	0.94	4.08
2	Randy Johnson R. Johnson	32	5/7/2001 - 5/13/2001	2	1	0	1.000	2	1.06	0	0	0	17.0	7	2	2	0	4	1	0	0	61	1	16.94	2.12	8.00	0.00	52.5	6.6	0.65	.292	1.06	3.71
3	Red Ames R. Ames	32	9/3/1906 - 9/9/1906	3	1	1	.500	3		1	0	0	24.0	14		4	0	4	0	0		85	1	12.00	1.50	8.00	0.00	37.6	4.7	0.75	.286	1.50	5.25
4	Randy Johnson R. Johnson	30	9/21/1992 - 9/27/1992	2	0	1	.000	2	2.81	1	0	0	16.0	12	5	5	1	6	0	0	0	65	0	16.88	3.38	5.00	0.56	46.2	9.2	1.13	.393	2.81	6.75
5	Roger Clemens R. Clemens	30	4/28/1986 - 5/4/1986	2	2	0	1.000	2	1.06	1	0	0	17.0	6	2	2	2	2	0	0	0	59	0	15.88	1.06	15.00	1.06	50.8	3.4	0.47	.160	1.06	3.18
6	Rube Waddell R. Waddell	30	4/20/1903 - 4/26/1903	3	1	2	.333	3	3.12	3	0	0	26.0	25	9	14	0	5	1	0		111	2	10.38	1.73	6.00	0.00	27.0	4.5	1.15	.333	4.85	8.65
7	Gerrit Cole G. Cole	29	9/2/2019 - 9/8/2019	2	1	0	1.000	2	1.29	0	0	0	14.0	4	2	2	2	2	0	0	0	48	1	18.64	1.29	14.50	1.29	60.4	4.2	0.43	.133	1.29	2.57
8	Ron Guidry R. Guidry	29	6/12/1978 - 6/18/1978	2	2	0	1.000	2	0.00	2	2	0	18.0	7	0	0	0	4	0	0	0	65	0	14.50	2.00	7.25	0.00	44.6	6.2	0.61	.219	0.00	3.50
9	Nolan Ryan N. Ryan	29	6/6/1977 - 6/12/1977	2	1	0	1.000	2	0.00	0	0	0	16.2	9	0	3	0	12	1	0	1	72	2	15.66	6.48	2.42	0.00	40.3	16.7	1.26	.300	1.62	4.86
10	Nolan Ryan N. Ryan	29	9/25/1972 - 10/1/1972	2	2	0	1.000	2	1.00	2	0	0	18.0	8	2	3	0	8	0	0	1	71	0	14.50	4.00	3.63	0.00	40.8	11.3	0.89	.235	1.50	4.00
11	Jack Coombs J. Coombs	29	8/1/1910 - 8/7/1910	3	1	1	.500	3		2	2	0	27.0	13		4	0	11	1	0		101	2	9.67	3.67	2.64	0.00	28.7	10.9	0.89	.217	1.33	4.33
12	Doc White D. White	29	9/1/1902 - 9/7/1902	4	2	2	.500	3	2.89	3	0	0	28.0	27		13	0	7	0	1			1	9.32	2.25	4.14	0.00		6.0	1.21	.338	4.18	8.68
13	Corey Kluber C. Kluber	28	9/15/2014 - 9/21/2014	2	2	0	1.000	2	1.80	0	0	0	15.0	14	3	3	0	3	0	0	0	62	0	16.80	1.80	9.33	0.00	45.2	4.8	1.13	.452	1.80	8.40
14	Randy Johnson R. Johnson	28	8/19/2002 - 8/25/2002	2	1	0	1.000	2	1.13	1	1	0	16.0	11	2	2	1	5	1	0	0	65	0	15.75	2.81	5.60	0.56	43.1	7.7	1.00	.333	1.13	6.19
15	Nolan Ryan N. Ryan	28	8/12/1974 - 8/18/1974	2	2	0	1.000	2	2.76	1	0	0	16.1	14	5	5	0	5	0	0	1	69	1	15.43	2.76	5.60	0.00	40.6	7.2	1.16	.389	2.76	7.71
16	Nolan Ryan N. Ryan	28	7/9/1973 - 7/15/1973	2	1	1	.500	2	3.60	1	1	0	15.0	8	6	6	1	10	0	0	0	63	0	16.80	6.00	2.80	0.60	44.4	15.9	1.20	.292	3.60	4.80
17	Don Wilson D. Wilson	28	6/12/1967 - 6/18/1967	2	2	0	1.000	2	0.50	2	1	0	18.0	8	1	4	1	5	0	0	0	68	0	14.00	2.50	5.60	0.50	41.2	7.4	0.72	.206	2.00	4.00
18	Sandy Koufax S. Koufax	28	8/31/1959 - 9/6/1959	2	1	1	.500	2	2.37	2	0	0	19.0	12	5	5	2	9	0	0	2	78	0	13.26	4.26	3.11	0.95	35.9	11.5	1.11	.256	2.37	5.68
19	Bob Feller B. Feller	28	9/26/1938 - 10/2/1938	2	1	1	.500	2	2.50	2	0	0	18.0	12	5	5	0	12	1	0		78	0	14.00	6.00	2.33	0.00	35.9	15.4	1.33	.324	2.50	6.00
20	Orval Overall O. Overall	28	8/31/1908 - 9/6/1908	3	2	1	.667	3		2	2	0	26.0	16		3	0	5	0	0		98	1	9.69	1.73	5.60	0.00	28.6	5.1	0.81	.246	1.04	5.54
21	Chris Sale C. Sale	27	5/13/2019 - 5/19/2019	2	0	0		2	3.65	0	0	0	12.1	7	5	5	2	5	1	0	0	50	1	19.70	3.65	5.40	1.46	54.0	10.0	0.97	.333	3.65	5.11
22	Max Scherzer M. Scherzer	27	9/28/2015 - 10/4/2015	2	2	0	1.000	2	0.53	1	1	0	17.0	2	1	1	0	3	0	0	0	57	0	14.29	1.59	9.00	0.00	47.4	5.3	0.29	.074	0.53	1.06
23	Mark Prior M. Prior	27	9/15/2003 - 9/21/2003	2	2	0	1.000	2	1.65	0	0	0	16.1	14	3	3	1	3	1	0	0	65	0	14.88	1.65	9.00	0.55	41.5	4.6	1.04	.394	1.65	7.71
24	Pedro Martinez P. Martinez	27	7/17/2000 - 7/23/2000	2	2	0	1.000	2	0.53	1	1	0	17.0	11	1	1	0	3	1	0	0	66	0	14.29	1.59	9.00	0.00	40.9	4.5	0.82	.314	0.53	5.82
25	Randy Johnson R. Johnson	27	8/30/1999 - 9/5/1999	2	0	1	.000	2	3.60	0	0	0	15.0	11	6	7	3	2	0	0	0	58	0	16.20	1.20	13.50	1.80	46.6	3.4	0.87	.308	4.20	6.60