Stan Musial has the most career games by a player against a team, with 432 games against the Dodgers.

Interpreted as:

MLB player most regular-season game against team

	NAME	G	OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Stan Musial S. Musial	432	Dodgers	1,530	299	522	108	30	74	271	249	13	90	13	1	1,805	912	212	5	8	15	39	.341	.436	.596	1.032
2	Stan Musial S. Musial	428	Reds	1,574	275	500	92	22	66	275	224	7	94	9	4	1,815	834	180	4	6	24	36	.318	.404	.530	.934
3	Stan Musial S. Musial	427	Braves	1,572	258	515	108	25	60	259	204	5	105	10	8	1,787	853	193	4	2	15	36	.328	.406	.543	.949
4	Stan Musial S. Musial	426	Pirates	1,546	275	526	108	27	58	253	238	5	79	14	4	1,806	862	193	8	9	21	31	.340	.428	.558	.985
5	Stan Musial S. Musial	422	Cubs	1,550	252	492	104	19	67	286	217	4	106	11	4	1,784	835	190	1	12	12	36	.317	.400	.539	.939
6	Stan Musial S. Musial	417	Phillies	1,547	297	522	116	35	54	261	197	8	110	12	4	1,765	870	205	8	5	13	30	.337	.414	.562	.976
7	Stan Musial S. Musial	417	Giants	1,494	272	504	82	18	89	312	245	11	100	8	6	1,764	889	189	6	8	24	38	.337	.432	.595	1.027
8	Tristram Speaker T. Speaker	410	Yankees	1,517	284	499	120	24	27		185	13		66		1,762	748	171	47				.329	.406	.493	.899
9	Ty Cobb T. Cobb	409	Yankees	1,527	319	578	112	49	23		171	10		96		1,740	857	184	32				.379	.444	.561	1.006
10	Mel Ott M. Ott	406	Pirates	1,377	285	436	65	7	83	305	280	12	116	18		1,685	764	155	16			7	.317	.436	.555	.991
11	Tristram Speaker T. Speaker	405	White Sox	1,477	240	511	119	32	11		189	10		46		1,712	727	162	36				.346	.424	.492	.916
12	Eddie Collins E. Collins	405	Red Sox	1,457	242	492	69	25	6		191	14		96		1,729	629	100	67				.338	.419	.432	.851
13	Eddie Collins E. Collins	404	Indians	1,459	252	491	73	28	2		220	10		98		1,780	626	103	91				.337	.427	.429	.856
14	Eddie Collins E. Collins	403	Tigers	1,426	291	498	69	24	5		242	11		125		1,755	630	98	76				.349	.447	.442	.889
15	Mel Ott M. Ott	402	Cubs	1,398	251	423	72	14	77	251	217	10	155	9		1,643	754	163	18			9	.303	.400	.539	.939
16	Ty Cobb T. Cobb	402	Red Sox	1,518	290	562	90	47	12	254	169	17		130		1,743	782	149	39				.370	.439	.515	.954
17	Eddie Collins E. Collins	402	Yankees	1,426	281	489	69	27	12		196	8		100		1,696	648	108	66				.343	.425	.454	.880
18	Mel Ott M. Ott	399	Cardinals	1,385	243	400	50	9	66	231	253	7	156	4		1,658	666	125	13			4	.289	.401	.481	.882
19	Tristram Speaker T. Speaker	398	Tigers	1,506	278	511	110	32	17		209	14		77		1,763	736	159	34				.339	.425	.489	.913
20	Ty Cobb T. Cobb	397	Senators	1,441	271	545	89	36	15		189	13		125		1,681	751	140	38				.378	.455	.521	.976
21	Rabbit Maranville R. Maranville	396	Giants	1,475	177	363	53	21	5		114	7	112	30		1,638	473	79	42				.246	.303	.321	.624
22	Tristram Speaker T. Speaker	395	Athletics	1,423	282	479	108	31	9		204	13		64		1,696	676	148	56				.337	.424	.475	.899
23	Eddie Collins E. Collins	393	Senators	1,358	224	404	54	19	5		227	11		112		1,665	511	78	69				.297	.402	.376	.779
24	Tristram Speaker T. Speaker	392	Browns	1,448	286	519	100	32	21		196	15		65		1,698	746	153	39				.358	.440	.515	.955
25	Eddie Collins E. Collins	392	Browns	1,398	287	478	52	34	12		220	15		120		1,704	634	98	71				.342	.437	.454	.890