| NAME | W | L | W% | G | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CC Sabathia | 162 | 90 | .643 | 319 | 319 | 3.46 | 1,928 | 33 | 11 | 0 | 2187.1 | 2,048 | 841 | 930 | 200 | 585 | 71 | 0 | 33 | 9,044 | 40 | 7.93 | 2.41 | 3.30 | 0.82 | 21.3 | 6.5 | 1.20 | .295 | 3.83 | 80 | 3.41 | 79 | 8.43 | 216.6 | |
| 2 | R. Halladay | 144 | 74 | .661 | 272 | 271 | 3.18 | 1,510 | 53 | 15 | 0 | 1907.2 | 1,801 | 675 | 723 | 162 | 350 | 58 | 0 | 20 | 7,721 | 30 | 7.12 | 1.65 | 4.31 | 0.76 | 19.6 | 4.5 | 1.13 | .291 | 3.41 | 75 | 3.26 | 76 | 8.50 | 214.5 | |
| 3 | J. Verlander | 137 | 77 | .640 | 266 | 266 | 3.41 | 1,671 | 20 | 6 | 0 | 1772.0 | 1,565 | 671 | 730 | 156 | 545 | 64 | 0 | 20 | 7,333 | 60 | 8.49 | 2.77 | 3.07 | 0.79 | 22.8 | 7.4 | 1.19 | .288 | 3.71 | 79 | 3.38 | 79 | 7.95 | 172 | |
| 4 | C. Lee | 136 | 82 | .624 | 304 | 300 | 3.52 | 1,702 | 28 | 12 | 0 | 2012.2 | 1,969 | 787 | 853 | 209 | 424 | 47 | 1 | 10 | 8,311 | 37 | 7.61 | 1.90 | 4.01 | 0.93 | 20.5 | 5.1 | 1.19 | .297 | 3.81 | 83 | 3.44 | 82 | 8.80 | 160.6 | |
| 5 | M. Buehrle | 133 | 107 | .554 | 325 | 325 | 3.89 | 1,244 | 18 | 5 | 0 | 2140.2 | 2,301 | 925 | 1,017 | 248 | 466 | 49 | 0 | 33 | 8,949 | 17 | 5.23 | 1.96 | 2.67 | 1.04 | 13.9 | 5.2 | 1.29 | .296 | 4.28 | 88 | 4.15 | 94 | 9.67 | 65.9 | |
| 6 | B. Arroyo | 129 | 113 | .533 | 332 | 326 | 4.10 | 1,354 | 14 | 6 | 0 | 2074.1 | 2,094 | 944 | 1,027 | 291 | 534 | 91 | 1 | 40 | 8,742 | 32 | 5.87 | 2.32 | 2.54 | 1.26 | 15.5 | 6.1 | 1.27 | .279 | 4.46 | 96 | 4.51 | 106 | 9.09 | -49.6 | |
| 7 | D. Haren | 126 | 104 | .548 | 313 | 302 | 3.69 | 1,693 | 16 | 6 | 1 | 1973.2 | 1,916 | 810 | 881 | 238 | 404 | 51 | 4 | 30 | 8,158 | 82 | 7.72 | 1.84 | 4.19 | 1.09 | 20.8 | 5.0 | 1.18 | .291 | 4.02 | 89 | 3.63 | 87 | 8.74 | 123 | |
| 8 | T. Hudson | 125 | 78 | .616 | 271 | 270 | 3.56 | 1,100 | 12 | 7 | 0 | 1761.2 | 1,684 | 696 | 744 | 134 | 508 | 75 | 0 | 50 | 7,334 | 43 | 5.62 | 2.60 | 2.17 | 0.68 | 15.0 | 6.9 | 1.24 | .281 | 3.80 | 86 | 3.82 | 93 | 8.60 | 62.6 | |
| 9 | R. Oswalt | 120 | 85 | .585 | 281 | 266 | 3.48 | 1,392 | 17 | 7 | 0 | 1743.1 | 1,742 | 675 | 715 | 152 | 405 | 64 | 3 | 28 | 7,256 | 26 | 7.19 | 2.09 | 3.44 | 0.78 | 19.2 | 5.6 | 1.23 | .303 | 3.69 | 83 | 3.43 | 80 | 8.99 | 168.8 | |
| 10 | J. Lackey | 119 | 87 | .578 | 273 | 272 | 4.00 | 1,406 | 13 | 6 | 0 | 1753.0 | 1,798 | 780 | 846 | 174 | 510 | 93 | 0 | 18 | 7,472 | 83 | 7.22 | 2.62 | 2.76 | 0.89 | 18.8 | 6.8 | 1.32 | .307 | 4.34 | 92 | 3.81 | 90 | 9.23 | 85.6 | |
| 11 | D. Lowe | 118 | 110 | .518 | 318 | 290 | 4.26 | 1,115 | 8 | 3 | 1 | 1764.0 | 1,900 | 835 | 940 | 152 | 533 | 36 | 13 | 40 | 7,574 | 30 | 5.69 | 2.72 | 2.09 | 0.78 | 14.7 | 7.0 | 1.38 | .305 | 4.80 | 102 | 3.91 | 93 | 9.69 | 60.2 | |
| 12 | A.J. Burnett | 117 | 100 | .539 | 293 | 290 | 4.03 | 1,738 | 14 | 4 | 0 | 1829.0 | 1,707 | 818 | 894 | 187 | 695 | 96 | 1 | 16 | 7,802 | 121 | 8.55 | 3.42 | 2.50 | 0.92 | 22.3 | 8.9 | 1.31 | .299 | 4.40 | 96 | 3.81 | 90 | 8.40 | 86.8 | |
| 13 | J. Santana | 116 | 66 | .637 | 243 | 243 | 3.02 | 1,590 | 15 | 10 | 0 | 1629.1 | 1,363 | 546 | 587 | 179 | 401 | 27 | 0 | 12 | 6,573 | 39 | 8.78 | 2.22 | 3.97 | 0.99 | 24.2 | 6.1 | 1.08 | .271 | 3.24 | 72 | 3.36 | 80 | 7.53 | 156 | |
| 14 | J. Beckett | 115 | 83 | .581 | 264 | 264 | 4.04 | 1,505 | 11 | 5 | 0 | 1661.2 | 1,562 | 746 | 797 | 196 | 479 | 67 | 0 | 20 | 6,950 | 46 | 8.15 | 2.59 | 3.14 | 1.06 | 21.7 | 6.9 | 1.23 | .290 | 4.32 | 92 | 3.80 | 91 | 8.46 | 72.9 | |
| 15 | J. Peavy | 114 | 80 | .588 | 257 | 256 | 3.38 | 1,623 | 15 | 6 | 0 | 1652.2 | 1,426 | 621 | 651 | 162 | 469 | 56 | 0 | 31 | 6,761 | 29 | 8.84 | 2.55 | 3.46 | 0.88 | 24.0 | 6.9 | 1.15 | .284 | 3.55 | 83 | 3.36 | 80 | 7.77 | 162 | |
| 16 | C. Zambrano | 114 | 70 | .620 | 284 | 253 | 3.68 | 1,372 | 7 | 4 | 0 | 1629.0 | 1,416 | 666 | 725 | 141 | 733 | 87 | 7 | 27 | 6,963 | 45 | 7.58 | 4.05 | 1.87 | 0.78 | 19.7 | 10.5 | 1.32 | .275 | 4.01 | 85 | 4.04 | 94 | 7.82 | 47.3 | |
| 17 | J. Weaver | 113 | 60 | .653 | 231 | 231 | 3.24 | 1,236 | 11 | 6 | 0 | 1474.2 | 1,296 | 531 | 561 | 158 | 390 | 29 | 0 | 11 | 6,016 | 31 | 7.54 | 2.38 | 3.17 | 0.96 | 20.5 | 6.5 | 1.14 | .271 | 3.42 | 78 | 3.66 | 88 | 7.91 | 80.4 | |
| 18 | F. Hernandez | 110 | 86 | .561 | 269 | 269 | 3.20 | 1,703 | 23 | 9 | 0 | 1824.2 | 1,669 | 648 | 722 | 145 | 526 | 57 | 0 | 15 | 7,513 | 98 | 8.40 | 2.59 | 3.24 | 0.72 | 22.7 | 7.0 | 1.20 | .300 | 3.56 | 78 | 3.22 | 77 | 8.23 | 190.5 | |
| 19 | T. Lilly | 108 | 89 | .548 | 260 | 260 | 4.00 | 1,306 | 3 | 2 | 0 | 1552.0 | 1,404 | 689 | 732 | 226 | 507 | 42 | 0 | 28 | 6,518 | 36 | 7.57 | 2.94 | 2.58 | 1.31 | 20.0 | 7.8 | 1.23 | .265 | 4.24 | 93 | 4.36 | 102 | 8.14 | -11.2 | |
| 20 | J. Marquis | 107 | 99 | .519 | 272 | 269 | 4.59 | 919 | 8 | 5 | 0 | 1613.1 | 1,709 | 822 | 906 | 203 | 617 | 77 | 0 | 29 | 7,059 | 45 | 5.13 | 3.44 | 1.49 | 1.13 | 13.0 | 8.7 | 1.44 | .287 | 5.05 | 109 | 4.88 | 116 | 9.53 | -117.8 | |
| 21 | A. Pettitte | 107 | 75 | .588 | 248 | 245 | 3.74 | 1,173 | 3 | 1 | 0 | 1523.1 | 1,547 | 633 | 699 | 145 | 452 | 24 | 1 | 21 | 6,404 | 29 | 6.93 | 2.67 | 2.60 | 0.86 | 18.3 | 7.1 | 1.31 | .304 | 4.13 | 86 | 3.73 | 85 | 9.14 | 108.3 | |
| 22 | Z. Greinke | 106 | 82 | .564 | 300 | 259 | 3.65 | 1,480 | 13 | 4 | 1 | 1669.2 | 1,634 | 677 | 729 | 162 | 425 | 52 | 8 | 13 | 6,948 | 48 | 7.98 | 2.29 | 3.48 | 0.87 | 21.3 | 6.1 | 1.23 | .305 | 3.93 | 86 | 3.42 | 82 | 8.81 | 141.7 | |
| 23 | E. Santana | 105 | 90 | .538 | 268 | 265 | 4.19 | 1,328 | 14 | 7 | 0 | 1686.2 | 1,634 | 786 | 847 | 229 | 526 | 80 | 1 | 24 | 7,141 | 61 | 7.09 | 2.81 | 2.52 | 1.22 | 18.6 | 7.4 | 1.28 | .282 | 4.52 | 100 | 4.36 | 105 | 8.72 | -38 | |
| 24 | B. Zito | 104 | 114 | .477 | 311 | 300 | 4.41 | 1,272 | 3 | 1 | 0 | 1801.2 | 1,753 | 883 | 947 | 211 | 767 | 67 | 8 | 45 | 7,790 | 36 | 6.35 | 3.83 | 1.66 | 1.05 | 16.3 | 9.8 | 1.40 | .282 | 4.73 | 108 | 4.59 | 111 | 8.76 | -92.1 | |
| 25 | J. Garland | 102 | 85 | .545 | 250 | 248 | 4.29 | 833 | 10 | 5 | 0 | 1580.1 | 1,679 | 753 | 823 | 186 | 471 | 45 | 0 | 35 | 6,723 | 30 | 4.74 | 2.68 | 1.77 | 1.06 | 12.4 | 7.0 | 1.36 | .288 | 4.69 | 98 | 4.55 | 104 | 9.56 | -22.9 | |