The New York Yankees have the highest run differential by a team, with a differential of 13,145 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,145	19,088	.570	10,821	8,179	650,551	92,746	172,690	28,679	5,498	17,354	86,182	68,692	4,936	95,073	11,671	2,810	737,068	264,427	51,531	9,597	3,292	2,842	10,704	.265	.339	.406	.745
2	Giants	7,477	21,798	.535	11,583	10,052	743,896	100,766	195,638	31,386	7,042	15,609	90,234	68,403	5,690	99,804	16,533	3,150	832,686	287,935	54,037	11,672	3,025	4,020	10,204	.263	.329	.387	.716
3	Dodgers	6,257	21,715	.532	11,478	10,098	739,914	98,064	193,324	31,103	7,010	14,171	88,278	69,010	5,161	100,574	17,353	3,553	830,008	280,960	52,284	12,774	3,073	3,743	9,966	.261	.327	.380	.707
4	Cubs	3,627	22,329	.513	11,372	10,796	764,133	102,817	200,108	33,799	7,362	15,286	88,402	68,649	5,291	105,260	15,822	3,075	854,015	294,489	56,447	13,027	2,915	3,524	9,975	.262	.326	.385	.711
5	Red Sox	3,595	19,377	.518	9,994	9,300	663,182	90,490	176,937	33,171	5,603	14,635	83,921	66,904	4,820	95,829	9,648	2,554	748,848	265,219	53,409	10,598	3,344	3,002	11,567	.267	.337	.400	.737
6	Guardians	2,239	19,385	.513	9,889	9,405	660,669	87,611	174,866	31,184	5,501	13,941	80,972	62,699	4,844	94,826	11,934	3,393	743,038	258,875	50,626	11,465	3,361	2,549	10,546	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,958	20,681	.513	10,545	10,005	707,411	92,537	187,977	31,868	7,052	12,887	84,593	64,269	5,219	98,377	15,024	3,619	792,024	272,610	51,807	11,977	3,148	3,778	10,153	.266	.330	.385	.715
9	Braves	1,549	22,290	.504	11,148	10,988	763,155	99,624	198,192	32,143	6,302	15,083	86,666	67,596	5,075	100,366	14,104	3,070	851,399	288,188	53,528	12,686	2,887	3,659	10,400	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	773	21,914	.504	10,973	10,802	746,659	98,340	194,534	32,428	7,561	14,356	87,480	66,799	5,511	102,501	18,175	3,414	834,848	285,152	54,345	12,665	3,046	3,649	9,734	.261	.325	.382	.707
13	Astros	758	10,054	.503	5,052	4,997	341,200	42,887	86,996	15,950	2,174	8,460	40,365	32,423	2,915	63,131	7,168	3,139	383,291	132,674	26,584	4,031	2,722	3,145	7,438	.255	.323	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	378	7,626	.499	3,801	3,822	261,268	35,259	67,950	13,579	1,493	8,293	33,446	24,229	2,436	49,131	4,582	1,966	291,574	109,394	23,365	1,507	2,134	1,406	5,950	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	343	19,412	.503	9,724	9,595	661,965	89,141	174,875	29,640	6,302	14,611	82,092	65,632	4,457	96,964	11,299	2,939	746,179	260,952	50,553	11,009	3,116	2,450	10,729	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331