The Houston Astros had the highest run differential by a team in 2018, with a differential of 263 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	263	2018	162	.636	103	59	5,453	797	1,390	278	18	205	763	565	61	1,197	71	26	6,138	2,319	501	14	45	19	156	.255	.329	.425	.754
2	Red Sox	229	2018	162	.667	108	54	5,623	876	1,509	355	31	208	829	569	55	1,253	125	31	6,302	2,550	594	7	48	38	130	.268	.339	.453	.792
3	Dodgers	194	2018	163	.564	92	71	5,572	804	1,394	296	33	235	756	647	61	1,436	75	24	6,358	2,461	564	39	39	47	119	.250	.333	.442	.774
4	Yankees	182	2018	162	.617	100	62	5,515	851	1,374	269	23	267	821	625	62	1,421	63	21	6,271	2,490	559	10	59	21	107	.249	.329	.451	.781
5	Indians	170	2018	162	.562	91	71	5,595	818	1,447	297	19	216	786	554	80	1,189	135	36	6,298	2,430	532	25	44	32	98	.259	.332	.434	.766
6	Athletics	139	2018	162	.599	97	65	5,579	813	1,407	322	20	227	778	550	76	1,381	35	21	6,255	2,450	569	6	44	18	136	.252	.325	.439	.764
7	Cubs	116	2018	163	.583	95	68	5,624	761	1,453	286	34	167	722	576	78	1,388	66	38	6,364	2,308	487	40	46	67	107	.258	.333	.410	.744
8	Braves	102	2018	162	.556	90	72	5,582	759	1,433	314	29	175	717	511	66	1,290	90	36	6,251	2,330	518	49	43	53	99	.257	.324	.417	.742
9	Brewers	95	2018	163	.589	96	67	5,542	754	1,398	252	24	218	711	537	58	1,458	124	32	6,207	2,352	494	29	41	32	128	.252	.323	.424	.747
10	Nationals	89	2018	162	.506	82	80	5,517	771	1,402	284	25	191	737	631	59	1,289	119	33	6,288	2,309	500	41	40	56	104	.254	.335	.419	.753
11	Rays	70	2018	162	.556	90	72	5,475	716	1,415	274	43	150	664	540	101	1,388	128	51	6,194	2,225	467	28	50	17	122	.258	.333	.406	.740
12	Cardinals	68	2018	162	.543	88	74	5,498	759	1,369	248	9	205	725	525	80	1,380	63	32	6,197	2,250	462	46	48	40	92	.249	.321	.409	.730
13	Diamondbacks	49	2018	162	.506	82	80	5,460	693	1,283	259	50	176	658	560	52	1,460	79	25	6,155	2,170	485	38	45	36	110	.235	.310	.397	.707
14	Rockies	35	2018	163	.558	91	72	5,541	780	1,418	280	42	210	748	507	51	1,397	95	33	6,178	2,412	532	42	37	38	114	.256	.322	.435	.757
15	Pirates	-1	2018	161	.509	82	79	5,447	692	1,381	290	38	157	665	474	59	1,229	70	38	6,063	2,218	485	31	52	38	121	.254	.317	.407	.725
16	Angels	-1	2018	162	.494	80	82	5,472	721	1,323	249	23	214	690	514	73	1,300	89	22	6,105	2,260	486	7	39	38	111	.242	.313	.413	.726
17	Mets	-31	2018	162	.475	77	85	5,468	676	1,282	265	34	170	649	566	73	1,404	71	39	6,177	2,125	469	28	42	36	116	.234	.312	.389	.701
18	Mariners	-34	2018	162	.549	89	73	5,513	677	1,402	256	32	176	644	430	70	1,221	79	37	6,083	2,250	464	29	41	17	128	.254	.314	.408	.722
19	Twins	-37	2018	162	.481	78	84	5,526	738	1,379	317	22	166	704	534	37	1,328	47	27	6,154	2,238	505	19	38	25	89	.250	.318	.405	.723
20	Phillies	-51	2018	162	.494	80	82	5,425	677	1,270	241	30	186	653	582	64	1,520	69	26	6,135	2,129	457	32	32	33	102	.234	.314	.392	.706
21	Giants	-96	2018	162	.451	73	89	5,541	603	1,324	255	30	133	573	448	49	1,467	77	34	6,113	2,038	418	33	42	40	113	.239	.300	.368	.667
22	Rangers	-111	2018	162	.414	67	95	5,453	737	1,308	266	24	194	696	555	88	1,484	74	35	6,163	2,204	484	33	34	16	104	.240	.318	.404	.722
23	Reds	-123	2018	162	.414	67	95	5,532	696	1,404	251	25	172	665	559	65	1,376	77	33	6,240	2,221	448	49	35	35	128	.254	.328	.401	.729
24	Blue Jays	-123	2018	162	.451	73	89	5,477	709	1,336	320	16	217	680	499	58	1,387	47	30	6,076	2,339	553	5	37	15	118	.244	.312	.427	.739
25	Padres	-150	2018	162	.407	66	96	5,486	617	1,289	250	30	162	583	471	31	1,523	95	36	6,059	2,085	442	35	36	28	122	.235	.297	.380	.677