15 teams are tied for the most games in a game with 20+ runs, with 1 game. The first three are the San Diego Padres on May 10 and on July 16, 2021, the Cincinnati Reds on April 20 and on May 26, 2022 and the New York Yankees on March 29 and on September 15, 2020.

Interpreted as:

MLB team most 20 or more run game in a regular-season game

	TEAM	G	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	1	21	5/10/2025	SDP	@	COL	W 21-0	50	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
2	Reds	1	24	4/20/2025	CIN	@	BAL	W 24-2	51	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
3	Yankees	1	20	3/29/2025	NYY	vs	MIL	W 20-9	40	16	2	0	9	20	8	2	5	0	0	51	45	11	0	1	0	0	.400	.510	1.125	1.635
4	Dodgers	1	20	9/19/2024	LAD	@	MIA	W 20-4	39	16	3	0	3	19	10	2	6	4	0	53	28	6	0	2	0	0	.410	.528	.718	1.246
5	Rockies	1	20	7/24/2024	COL	vs	BOS	W 20-7	45	21	4	0	4	20	2	1	10	0	0	50	37	8	0	2	0	0	.467	.480	.822	1.302
6	Athletics	1	20	5/4/2024	OAK	vs	MIA	W 20-4	45	21	1	1	6	20	6	3	3	0	0	54	42	8	0	0	0	1	.467	.556	.933	1.489
7	Twins	1	20	9/4/2023	MIN	@	CLE	W 20-6	46	20	2	0	6	20	6	0	4	0	0	53	40	8	0	1	0	0	.435	.491	.870	1.360
8	Braves	1	21	8/12/2023	ATL	@	NYM	W 21-3	48	22	5	0	6	21	6	1	8	3	0	55	45	11	0	0	0	0	.458	.527	.938	1.465
9	Cubs	1	20	8/1/2023	CHC	vs	CIN	W 20-9	43	21	4	0	7	19	4	1	6	3	0	49	46	11	0	1	0	1	.488	.531	1.070	1.600
10	Angels	1	25	6/24/2023	LAA	@	COL	W 25-1	52	28	5	0	5	25	6	1	3	0	0	59	48	10	0	0	0	3	.538	.593	.923	1.516
11	Blue Jays	1	20	5/23/2023	TOR	@	TBR	W 20-1	52	27	3	1	4	18	1	0	9	2	0	54	44	8	0	1	0	1	.519	.519	.846	1.365
12	Astros	1	21	8/18/2022	HOU	@	CWS	W 21-5	51	25	5	0	4	21	4	0	9	1	0	55	42	9	0	0	0	1	.490	.527	.824	1.351
13	Blue Jays	1	28	7/22/2022	TOR	@	BOS	W 28-5	57	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
14	Reds	1	20	5/26/2022	CIN	vs	CHC	W 20-5	38	20	3	1	2	20	7	0	4	0	1	49	31	6	1	3	1	0	.526	.563	.816	1.378
15	Cubs	1	21	4/23/2022	CHC	vs	PIT	W 21-0	48	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
16	Blue Jays	1	22	9/12/2021	TOR	@	BAL	W 22-7	45	19	5	0	5	22	8	2	8	0	0	55	39	10	0	0	0	0	.422	.527	.867	1.394
17	Red Sox	1	20	8/11/2021	BOS	vs	TBR	W 20-8	42	19	7	2	1	20	9	2	6	0	0	53	33	10	0	0	2	1	.452	.566	.786	1.352
18	Padres	1	24	7/16/2021	SDP	@	WSH	W 24-8	50	22	3	1	5	23	9	0	7	3	0	60	42	9	1	0	0	0	.440	.525	.840	1.365
19	Dodgers	1	22	7/10/2021	LAD	vs	ARI	W 22-1	44	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
20	Braves	1	20	6/30/2021	ATL	vs	NYM	W 20-2	43	20	4	0	4	20	6	1	6	1	1	50	36	8	0	0	0	0	.465	.540	.837	1.377
21	Braves	1	20	5/21/2021	ATL	vs	PIT	W 20-1	41	20	7	0	7	20	5	0	9	0	0	49	48	14	1	2	0	0	.488	.521	1.171	1.692
22	Yankees	1	20	9/15/2020	NYY	vs	TOR	W 20-6	41	16	5	0	6	20	7	2	9	0	0	50	39	11	0	0	0	0	.390	.500	.951	1.451
23	Braves	1	29	9/9/2020	ATL	vs	MIA	W 29-9	47	23	2	0	7	28	9	1	9	2	0	58	46	9	0	1	0	0	.489	.569	.979	1.548
24	Giants	1	23	9/1/2020	SFG	@	COL	W 23-5	52	27	8	1	4	23	5	1	6	1	0	59	49	13	0	1	0	0	.519	.559	.942	1.502
25	Athletics	1	21	9/10/2019	OAK	@	HOU	W 21-7	51	25	3	0	6	21	4	0	7	0	0	56	46	9	0	1	0	0	.490	.518	.902	1.420