The Los Angeles Angels and the Boston Red Sox are tied for the most runs by an AL team in a game against an NL team, with 25 runs.

Interpreted as:

MLB team most run al vs nl in a regular-season game

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Angels	25	6/24/2023	LAA	@	COL	W 25-1	52	28	5	0	5	25	6	1	3	0	0	59	48	10	0	0	0	3	.538	.593	.923	1.516
2	Red Sox	25	6/27/2003	BOS	vs	FLA	W 25-8	46	28	8	1	3	25	7	1	7	0	0	57	47	12	0	3	0	1	.609	.632	1.022	1.653
3	Orioles	22	6/13/1999	BAL	@	ATL	W 22-1	51	25	7	0	4	22	6	0	8	0	0	57	44	11	0	0	0	0	.490	.544	.863	1.407
4	Astros	21	10/2/2015	HOU	@	ARI	W 21-5	46	19	4	1	4	18	8	0	8	1	0	57	37	9	1	2	1	0	.413	.482	.804	1.286
5	Yankees	20	3/29/2025	NYY	vs	MIL	W 20-9	40	16	2	0	9	20	8	2	5	0	0	51	45	11	0	1	0	0	.400	.510	1.125	1.635
6	Athletics	20	5/4/2024	OAK	vs	MIA	W 20-4	45	21	1	1	6	20	6	3	3	0	0	54	42	8	0	0	0	1	.467	.556	.933	1.489
7	Yankees	20	8/30/2015	NYY	@	ATL	W 20-6	46	21	3	0	3	20	9	1	7	0	0	57	33	6	0	1	0	1	.457	.544	.717	1.261
8	White Sox	20	6/20/2006	CWS	vs	STL	W 20-6	49	24	3	0	4	19	1	2	5	0	0	52	39	7	0	0	0	0	.490	.519	.796	1.315
9	Yankees	20	6/19/2002	NYY	@	COL	W 20-10	45	18	7	0	3	19	8	3	7	2	0	58	34	10	0	2	2	0	.400	.500	.756	1.256
10	Indians	19	7/11/2018	CLE	vs	CIN	W 19-4	42	19	1	0	4	19	7	0	6	0	0	49	32	5	0	0	0	2	.452	.531	.762	1.293
11	Orioles	19	6/16/2015	BAL	vs	PHI	W 19-3	39	17	2	0	8	17	8	1	7	0	0	49	43	10	0	1	0	2	.436	.531	1.103	1.633
12	Red Sox	18	4/6/2025	BOS	vs	STL	W 18-7	46	21	8	0	1	17	4	0	5	1	0	50	32	9	0	0	0	0	.457	.500	.696	1.196
13	Athletics	18	7/14/2024	OAK	@	PHI	W 18-3	40	15	2	1	8	18	5	0	5	0	1	46	43	11	0	1	0	0	.375	.435	1.075	1.510
14	Blue Jays	18	9/20/2022	TOR	@	PHI	W 18-11	49	21	7	1	2	17	3	1	8	0	0	53	36	10	0	0	0	1	.429	.472	.735	1.206
15	Yankees	18	6/12/2022	NYY	vs	CHC	W 18-4	41	17	4	0	4	18	7	0	7	0	0	48	33	8	0	0	0	0	.415	.500	.805	1.305
16	Rangers	18	5/21/2005	TEX	vs	HOU	W 18-3	40	17	3	0	8	17	5	0	9	0	1	45	44	11	0	0	0	0	.425	.489	1.100	1.589
17	Rangers	18	7/4/2004	TEX	@	HOU	W 18-3	43	16	2	0	6	17	8	0	9	1	0	51	36	8	0	0	2	1	.372	.471	.837	1.308
18	Twins	17	6/12/2024	MIN	vs	COL	W 17-9	44	24	7	0	2	17	2	0	4	1	1	47	37	9	0	1	0	1	.545	.553	.841	1.394
19	Red Sox	17	4/27/2024	BOS	vs	CHC	W 17-0	43	21	6	0	2	17	2	2	6	1	0	49	33	8	1	1	0	0	.488	.521	.767	1.288
20	White Sox	17	5/7/2023	CWS	@	CIN	W 17-4	44	18	5	1	2	17	4	0	7	0	0	49	31	8	0	1	0	1	.409	.449	.705	1.154
21	White Sox	17	8/27/2021	CWS	vs	CHC	W 17-13	41	15	5	0	2	16	9	2	2	0	0	52	26	7	0	0	0	0	.366	.500	.634	1.134
22	Tigers	17	8/7/2020	DET	@	PIT	W 17-13	49	16	4	0	1	17	6	1	16	1	0	56	23	5	0	0	0	1	.327	.411	.469	.880
23	Blue Jays	17	5/29/2017	TOR	vs	CIN	W 17-2	46	23	5	0	3	16	7	1	1	0	0	54	37	8	0	0	0	1	.500	.574	.804	1.378
24	Royals	17	6/14/2007	KCR	vs	STL	W 17-8	38	15	3	2	1	17	7	1	5	0	0	46	25	6	0	0	0	1	.395	.500	.658	1.158
25	Royals	17	6/10/2007	KCR	vs	PHI	W 17-5	35	14	3	0	2	15	6	2	4	0	0	47	23	5	3	1	0	0	.400	.500	.657	1.157