The New York Yankees and the Chicago White Stockings are tied for the most runs in a game on September 25, with 21 runs.
| TEAM | R | DATE | TM | OPP | RESULT | AB | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Yankees | 21 | 9/25/1921 |  NYY | vs |  CLE | W 21-7 | 44 | 20 | 1 | 2 | 2 | 19 | 8 | 0 | 3 | 1 | 0 | 52 | 31 | 5 | 0 | .455 | .538 | .705 | 1.243 | |||
| 2 |  | White Stockings | 21 | 9/25/1885 |  CWS | @ | PRO | W 21-3 | ||||||||||||||||||||||
| 3 |  | Rockies | 19 | 9/25/2011 |  COL | @ |  HOU | W 19-3 | 48 | 25 | 1 | 1 | 4 | 18 | 5 | 1 | 4 | 0 | 1 | 58 | 40 | 6 | 1 | 3 | 0 | 0 | .521 | .544 | .833 | 1.377 |
| 4 | | Yankees | 19 | 9/25/1996 | NYY | vs |  MIL | W 19-2 | 42 | 20 | 4 | 1 | 2 | 17 | 8 | 1 | 4 | 1 | 0 | 52 | 32 | 7 | 0 | 1 | 1 | 2 | .476 | .558 | .762 | 1.320 |
| 5 |  | Reds | 18 | 9/25/1925 |  CIN | vs |  BKN | W 18-7 | 45 | 19 | 1 | 2 | 0 | 17 | 8 | 1 | 1 | 1 | 1 | 54 | 24 | 3 | 0 | .422 | .519 | .533 | 1.052 | |||
| 6 |  | Pirates | 18 | 9/25/1923 |  PIT | vs |  PHN | W 18-5 | 40 | 22 | 1 | 2 | 0 | 15 | 4 | 1 | 2 | 4 | 0 | 48 | 27 | 3 | 3 | .550 | .600 | .675 | 1.275 | |||
| 7 |  | Mets | 17 | 9/25/2016 |  NYM | vs | PHI | W 17-0 | 37 | 14 | 3 | 0 | 2 | 15 | 9 | 4 | 9 | 0 | 0 | 50 | 23 | 5 | 0 | 0 | 0 | 1 | .378 | .540 | .622 | 1.162 |
| 8 |  | Orioles | 17 | 9/25/1893 |  BAL | @ |  STL | W 17-5 | ||||||||||||||||||||||
| 9 | | Yankees | 16 | 9/25/2006 | NYY | @ |  TBD | W 16-1 | 45 | 20 | 3 | 0 | 4 | 16 | 5 | 1 | 3 | 0 | 0 | 51 | 35 | 7 | 0 | 0 | 0 | 2 | .444 | .510 | .778 | 1.288 |
| 10 |  | Pirates | 16 | 9/25/1948 |  PIT | vs | CIN | W 16-6 | 43 | 20 | 0 | 1 | 0 | 15 | 6 | 1 | 2 | 0 | 0 | 50 | 22 | 1 | 0 | 1 | .465 | .540 | .512 | 1.052 | ||
| 11 | Colonels | 16 | 9/25/1899 | LOU | @ | STL | W 16-3 | |||||||||||||||||||||||
| 12 | Spiders | 16 | 9/25/1891 | CLE | vs | CNN | W 16-8 | |||||||||||||||||||||||
| 13 |  | Red Sox | 15 | 9/25/2013 |  BOS | @ | COL | W 15-5 | 44 | 16 | 4 | 0 | 3 | 15 | 4 | 1 | 9 | 0 | 0 | 49 | 29 | 7 | 0 | 0 | 0 | 0 | .364 | .429 | .659 | 1.088 |
| 14 |  | Tigers | 15 | 9/25/2000 |  DET | @ | NYY | W 15-4 | 44 | 18 | 6 | 0 | 3 | 14 | 5 | 0 | 3 | 0 | 0 | 51 | 33 | 9 | 0 | 2 | 1 | 0 | .409 | .451 | .750 | 1.201 |
| 15 |  | Mariners | 15 | 9/25/1998 |  SEA | vs |  TEX | W 15-4 | 40 | 17 | 6 | 1 | 3 | 15 | 2 | 0 | 5 | 0 | 0 | 42 | 34 | 10 | 0 | 0 | 0 | 1 | .425 | .452 | .850 | 1.302 |
| 16 | | Yankees | 15 | 9/25/1990 | NYY | vs |  BAL | W 15-3 | 39 | 16 | 1 | 0 | 5 | 15 | 3 | 0 | 4 | 0 | 0 | 42 | 32 | 6 | 0 | 0 | 0 | 0 | .410 | .452 | .821 | 1.273 |
| 17 | | Yankees | 15 | 9/25/1977 | NYY | @ |  TOR | W 15-0 | 45 | 20 | 3 | 1 | 5 | 14 | 3 | 0 | 5 | 0 | 0 | 48 | 40 | 9 | 0 | 0 | 0 | 1 | .444 | .479 | .889 | 1.368 |
| 18 |  | Cardinals | 15 | 9/25/1947 | SLN | @ | PIT | W 15-3 | 48 | 22 | 6 | 0 | 1 | 15 | 4 | 1 | 1 | 0 | 0 | 53 | 31 | 7 | 0 | 2 | .458 | .509 | .646 | 1.155 | ||
| 19 |  | Bridegrooms | 15 | 9/25/1897 |  BKN | vs | PHI | W 15-3 | ||||||||||||||||||||||
| 20 | | Reds | 15 | 9/25/1895 | CIN | @ | STL | W 15-8 | ||||||||||||||||||||||
| 21 |  | Giants | 15 | 9/25/1894 |  NYG | @ | LOU | W 15-3 | ||||||||||||||||||||||
| 22 | | Gothams | 15 | 9/25/1885 | NYG | vs | BUF | W 15-1 | ||||||||||||||||||||||
| 23 | | Alleghenys | 15 | 9/25/1884 | PIT | vs | IND | W 15-4 | ||||||||||||||||||||||
| 24 | Grays | 15 | 9/25/1879 | PRO | @ |  BOS | W 15-4 | |||||||||||||||||||||||
| 25 |  | Angels | 14 | 9/25/2021 |  LAA | vs | SEA | W 14-1 | 37 | 14 | 1 | 2 | 1 | 14 | 8 | 1 | 8 | 0 | 0 | 46 | 22 | 4 | 0 | 0 | 0 | 1 | .378 | .500 | .595 | 1.095 |
Results may be incomplete. StatMuse has complete team, game-level data for runs going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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Astros 
Padres 
KCR 
MIA 
MIL 
