The San Diego Padres had the most runs by an NL team in a game in 2021, with 24 runs versus the Nationals on July 16, 2021.

Interpreted as:

MLB team most runs in a regular-season game 2021 nl

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	24	7/16/2021	SDP	@	WSH	W 24-8	50	22	3	1	5	23	9	0	7	3	0	60	42	9	1	0	0	0	.440	.525	.840	1.365
2	Dodgers	22	7/10/2021	LAD	vs	ARI	W 22-1	44	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
3	Braves	20	6/30/2021	ATL	vs	NYM	W 20-2	43	20	4	0	4	20	6	1	6	1	1	50	36	8	0	0	0	0	.465	.540	.837	1.377
4	Braves	20	5/21/2021	ATL	vs	PIT	W 20-1	41	20	7	0	7	20	5	0	9	0	0	49	48	14	1	2	0	0	.488	.521	1.171	1.692
5	Giants	19	5/20/2021	SFG	@	CIN	W 19-4	43	16	2	0	4	17	6	2	10	0	0	51	30	6	0	0	0	0	.372	.471	.698	1.168
6	Nationals	18	7/19/2021	WSH	vs	MIA	W 18-1	41	18	3	1	6	18	2	1	6	0	0	44	41	10	0	0	0	1	.439	.477	1.000	1.477
7	Phillies	17	9/16/2021	PHI	vs	CHC	W 17-8	39	16	6	0	1	17	6	2	6	0	0	48	25	7	1	0	0	1	.410	.511	.641	1.152
8	Brewers	17	8/12/2021	MIL	@	CHC	W 17-4	47	22	6	1	5	17	4	1	9	1	0	53	45	12	1	0	0	0	.468	.519	.957	1.477
9	Phillies	17	6/1/2021	PHI	@	CIN	W 17-3	44	18	2	0	7	17	6	0	11	1	0	51	41	9	1	0	0	0	.409	.480	.932	1.412
10	Nationals	17	5/14/2021	WSH	@	ARI	W 17-2	51	22	6	1	3	17	5	2	5	0	0	59	39	10	1	0	0	0	.431	.500	.765	1.265
11	Padres	16	5/21/2021	SDP	vs	SEA	W 16-1	40	17	2	1	3	16	6	0	8	2	0	46	30	6	0	0	0	1	.425	.500	.750	1.250
12	Dodgers	16	5/2/2021	LAD	@	MIL	W 16-4	44	18	2	0	3	16	4	3	3	0	0	52	29	5	1	0	0	0	.409	.490	.659	1.149
13	Cubs	16	4/21/2021	CHC	vs	NYM	W 16-4	36	13	2	0	1	15	8	1	8	1	0	45	18	3	0	0	0	1	.361	.489	.500	.989
14	Giants	15	9/11/2021	SFG	@	CHC	W 15-4	37	13	3	0	2	15	11	1	9	0	0	50	22	5	0	1	1	1	.351	.500	.595	1.095
15	Cardinals	15	9/3/2021	STL	@	MIL	W 15-4	39	12	1	0	6	15	5	2	8	1	0	46	31	7	0	0	0	0	.308	.413	.795	1.208
16	Phillies	15	8/1/2021	PHI	@	PIT	W 15-4	45	20	9	0	0	15	5	0	7	1	0	52	29	9	0	2	0	0	.444	.481	.644	1.125
17	Braves	15	7/24/2021	ATL	@	PHI	W 15-3	43	17	2	0	5	15	5	0	9	0	0	50	34	7	2	0	0	0	.395	.458	.791	1.249
18	Mets	15	7/19/2021	NYM	@	CIN	W 15-11	49	18	1	0	7	15	3	0	10	1	0	52	40	8	0	0	0	1	.367	.404	.816	1.220
19	Nationals	15	7/7/2021	WSH	@	SDP	W 15-5	45	17	5	0	1	15	3	2	3	0	0	51	25	6	1	0	1	0	.378	.440	.556	.996
20	Phillies	15	7/6/2021	PHI	@	CHC	W 15-10	43	16	4	0	3	14	4	1	12	1	0	49	29	7	0	1	0	0	.372	.429	.674	1.103
21	Brewers	15	6/30/2021	MIL	vs	CHC	W 15-7	36	12	2	0	3	13	9	2	9	0	0	47	23	5	0	0	0	1	.333	.489	.639	1.128
22	Nationals	15	6/30/2021	WSH	vs	TBR	W 15-6	40	18	2	1	3	15	6	1	11	4	0	48	31	6	0	1	0	1	.450	.521	.775	1.296
23	Cubs	15	4/23/2021	CHC	vs	MIL	W 15-2	40	17	6	1	4	15	5	1	8	0	0	46	37	11	0	0	0	1	.425	.500	.925	1.425
24	Reds	14	8/16/2021	CIN	vs	CHC	W 14-5	37	14	3	0	3	14	8	0	10	0	0	46	26	6	0	1	0	0	.378	.478	.703	1.181
25	Dodgers	14	8/15/2021	LAD	@	NYM	W 14-4	42	16	3	1	5	14	6	2	10	1	0	51	36	9	0	1	0	0	.381	.471	.857	1.328