Since 2021, the Toronto Blue Jays have the most runs by a team in a game, with 28 runs versus the Red Sox on July 22, 2022.

Interpreted as:

MLB team most runs in a regular-season game since 2021

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Blue Jays	28	7/22/2022	TOR	@	BOS	W 28-5	57	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
2	Angels	25	6/24/2023	LAA	@	COL	W 25-1	52	28	5	0	5	25	6	1	3	0	0	59	48	10	0	0	0	3	.538	.593	.923	1.516
3	Reds	24	4/20/2025	CIN	@	BAL	W 24-2	51	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
4	Padres	24	7/16/2021	SDP	@	WSH	W 24-8	50	22	3	1	5	23	9	0	7	3	0	60	42	9	1	0	0	0	.440	.525	.840	1.365
5	Blue Jays	22	9/12/2021	TOR	@	BAL	W 22-7	45	19	5	0	5	22	8	2	8	0	0	55	39	10	0	0	0	0	.422	.527	.867	1.394
6	Dodgers	22	7/10/2021	LAD	vs	ARI	W 22-1	44	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
7	Padres	21	5/10/2025	SDP	@	COL	W 21-0	50	24	4	1	5	20	5	0	4	0	0	56	45	10	0	1	0	0	.480	.518	.900	1.418
8	Braves	21	8/12/2023	ATL	@	NYM	W 21-3	48	22	5	0	6	21	6	1	8	3	0	55	45	11	0	0	0	0	.458	.527	.938	1.465
9	Astros	21	8/18/2022	HOU	@	CWS	W 21-5	51	25	5	0	4	21	4	0	9	1	0	55	42	9	0	0	0	1	.490	.527	.824	1.351
10	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
11	Yankees	20	3/29/2025	NYY	vs	MIL	W 20-9	40	16	2	0	9	20	8	2	5	0	0	51	45	11	0	1	0	0	.400	.510	1.125	1.635
12	Dodgers	20	9/19/2024	LAD	@	MIA	W 20-4	39	16	3	0	3	19	10	2	6	4	0	53	28	6	0	2	0	0	.410	.528	.718	1.246
13	Rockies	20	7/24/2024	COL	vs	BOS	W 20-7	45	21	4	0	4	20	2	1	10	0	0	50	37	8	0	2	0	0	.467	.480	.822	1.302
14	Athletics	20	5/4/2024	OAK	vs	MIA	W 20-4	45	21	1	1	6	20	6	3	3	0	0	54	42	8	0	0	0	1	.467	.556	.933	1.489
15	Twins	20	9/4/2023	MIN	@	CLE	W 20-6	46	20	2	0	6	20	6	0	4	0	0	53	40	8	0	1	0	0	.435	.491	.870	1.360
16	Cubs	20	8/1/2023	CHC	vs	CIN	W 20-9	43	21	4	0	7	19	4	1	6	3	0	49	46	11	0	1	0	1	.488	.531	1.070	1.600
17	Blue Jays	20	5/23/2023	TOR	@	TBR	W 20-1	52	27	3	1	4	18	1	0	9	2	0	54	44	8	0	1	0	1	.519	.519	.846	1.365
18	Reds	20	5/26/2022	CIN	vs	CHC	W 20-5	38	20	3	1	2	20	7	0	4	0	1	49	31	6	1	3	1	0	.526	.563	.816	1.378
19	Red Sox	20	8/11/2021	BOS	vs	TBR	W 20-8	42	19	7	2	1	20	9	2	6	0	0	53	33	10	0	0	2	1	.452	.566	.786	1.352
20	Braves	20	6/30/2021	ATL	vs	NYM	W 20-2	43	20	4	0	4	20	6	1	6	1	1	50	36	8	0	0	0	0	.465	.540	.837	1.377
21	Braves	20	5/21/2021	ATL	vs	PIT	W 20-1	41	20	7	0	7	20	5	0	9	0	0	49	48	14	1	2	0	0	.488	.521	1.171	1.692
22	Red Sox	19	5/23/2025	BOS	vs	BAL	W 19-5	45	20	6	0	3	19	8	0	7	0	0	53	35	9	0	0	0	1	.444	.528	.778	1.306
23	Dodgers	19	5/15/2025	LAD	vs	ATH	W 19-2	40	18	2	0	5	19	8	0	6	2	0	50	35	7	0	2	0	0	.450	.520	.875	1.395
24	Mets	19	4/28/2025	NYM	@	WSH	W 19-5	47	21	3	1	4	19	6	2	9	0	0	56	38	8	0	1	0	0	.447	.518	.809	1.326
25	Athletics	19	7/6/2024	OAK	vs	BAL	W 19-8	41	18	5	0	5	19	6	1	6	0	0	49	38	10	0	1	0	0	.439	.510	.927	1.437