Since 2022, the Colorado Rockies have lost the most games by a team, with 417 losses.

Interpreted as:

MLB team with most regular-season losses since 2022

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	417	231	.644	648	.356	21,898	2,698	5,376	1,115	127	651	2,590	1,748	219	6,021	293	115	24,087	8,698	1,893	61	161	43	507	.246	.306	.397	.703
2	White Sox	405	243	.625	648	.375	21,872	2,481	5,180	1,005	41	618	2,382	1,658	217	5,460	319	86	23,946	8,121	1,664	72	127	44	473	.237	.296	.371	.667
3	Athletics	393	255	.606	648	.394	21,604	2,529	5,004	1,010	71	723	2,428	1,926	241	5,793	405	108	23,999	8,325	1,804	87	141	44	456	.232	.300	.385	.685
4	Nationals	385	263	.594	648	.406	21,752	2,650	5,372	1,056	92	583	2,523	1,764	268	4,941	557	181	24,023	8,361	1,731	84	155	40	471	.247	.309	.384	.694
5	Angels	367	281	.566	648	.434	21,643	2,670	5,047	906	89	812	2,553	1,933	306	6,106	370	135	24,081	8,567	1,807	58	141	81	427	.233	.303	.396	.699
6	Pirates	363	285	.560	648	.440	21,589	2,531	5,006	989	98	594	2,421	2,047	226	5,889	427	128	24,089	7,973	1,681	73	154	56	411	.232	.303	.369	.672
7	Royals	359	289	.554	648	.446	21,717	2,702	5,337	1,061	138	630	2,613	1,735	240	4,940	512	154	23,975	8,564	1,829	86	197	60	389	.246	.306	.394	.700
8	Marlins	354	294	.546	648	.454	21,957	2,598	5,399	1,021	95	614	2,475	1,751	229	5,373	471	137	24,165	8,452	1,730	69	159	58	492	.246	.306	.385	.691
9	Reds	344	304	.531	648	.469	21,652	2,846	5,198	1,010	107	695	2,705	2,031	322	5,804	560	156	24,215	8,507	1,812	61	149	36	420	.240	.313	.393	.706
10	Tigers	331	317	.511	648	.489	21,754	2,658	5,151	968	139	635	2,545	1,875	224	5,801	269	87	24,051	8,302	1,742	32	166	42	395	.237	.302	.382	.683
11	Twins	331	317	.511	648	.489	21,887	2,894	5,339	1,091	85	785	2,758	2,080	343	5,685	303	92	24,510	8,955	1,961	41	159	49	472	.244	.317	.409	.726
12	Rangers	331	317	.511	648	.489	21,988	2,955	5,355	1,015	68	782	2,825	2,031	218	5,473	438	118	24,429	8,852	1,865	37	155	68	373	.244	.312	.403	.714
13	Giants	327	321	.505	648	.495	21,639	2,788	5,096	1,016	89	707	2,667	2,163	294	5,786	257	78	24,342	8,411	1,812	55	191	62	443	.236	.311	.389	.700
14	Cardinals	323	325	.498	648	.502	21,946	2,852	5,456	1,075	63	719	2,728	2,063	294	5,191	377	110	24,532	8,814	1,857	60	169	55	440	.249	.319	.402	.721
15	Red Sox	322	326	.497	648	.503	22,240	3,044	5,682	1,326	85	717	2,910	1,975	279	5,734	447	128	24,703	9,329	2,128	43	166	92	458	.255	.322	.419	.741
16	Diamondbacks	321	327	.495	648	.505	21,789	3,125	5,420	1,084	143	764	2,977	2,185	283	5,169	509	124	24,625	9,082	1,991	138	230	63	439	.249	.322	.417	.739
17	Cubs	316	332	.488	648	.512	21,865	3,005	5,381	1,054	119	748	2,873	2,177	277	5,478	555	136	24,564	8,917	1,921	61	184	62	386	.246	.320	.408	.728
18	Rays	306	342	.472	648	.528	21,782	2,844	5,341	1,065	80	698	2,705	1,975	276	5,697	627	179	24,216	8,660	1,843	39	144	45	398	.245	.314	.398	.712
19	Mets	300	348	.463	648	.537	21,819	3,023	5,414	1,034	82	817	2,908	2,112	398	5,255	433	77	24,564	9,063	1,933	64	171	75	451	.248	.323	.415	.739
20	Guardians	299	348	.462	647	.538	21,691	2,711	5,251	1,055	96	604	2,575	1,881	283	4,804	547	143	24,124	8,310	1,755	80	189	136	412	.242	.308	.383	.692
21	Blue Jays	299	349	.461	648	.539	22,034	2,990	5,654	1,173	70	735	2,872	2,080	267	4,877	315	110	24,597	9,172	1,978	61	155	70	524	.257	.326	.416	.742
22	Orioles	298	350	.460	648	.540	21,907	2,944	5,344	1,097	105	780	2,821	1,961	267	5,576	428	117	24,354	8,991	1,982	43	176	53	382	.244	.311	.410	.722
23	Mariners	295	353	.455	648	.545	21,707	2,890	5,109	973	53	830	2,767	2,259	405	6,071	502	122	24,576	8,678	1,856	51	154	73	423	.235	.317	.400	.717
24	Padres	294	354	.454	648	.546	21,819	2,919	5,459	1,061	68	700	2,790	2,195	236	4,876	412	112	24,531	8,756	1,829	115	166	76	465	.250	.323	.401	.724
25	Phillies	280	368	.432	648	.568	22,088	3,105	5,659	1,099	106	835	2,993	2,060	243	5,551	518	114	24,607	9,475	2,040	48	168	77	428	.256	.324	.429	.753