Since 1965, the New York Yankees have the most wins by a team, with 5,285 wins.

Interpreted as:

MLB team with most regular-season wins since 1965

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	5,285	4,223	.556	9,517	324,751	45,265	85,094	15,048	1,528	10,457	42,979	34,094	2,725	57,391	5,597	2,366	366,588	134,569	27,033	2,204	2,814	2,357	7,728	.262	.335	.414	.749
2	Dodgers	5,221	4,304	.548	9,528	323,532	41,130	83,053	14,258	1,760	8,700	38,797	31,262	2,491	59,851	6,538	2,846	364,163	126,931	24,718	4,316	2,562	3,182	6,844	.257	.325	.392	.717
3	Red Sox	5,092	4,429	.535	9,522	328,339	46,405	88,271	17,836	1,807	9,991	43,969	33,468	2,803	58,960	4,337	2,170	369,830	139,694	29,634	2,327	2,893	2,604	8,019	.269	.339	.425	.764
4	Cardinals	5,028	4,486	.528	9,523	324,367	41,951	84,722	15,426	2,166	7,757	39,490	30,886	2,631	58,841	7,228	3,052	364,405	127,751	25,349	3,825	2,696	3,209	7,144	.261	.328	.394	.722
5	Braves	4,953	4,555	.521	9,516	323,611	42,015	83,163	14,806	1,589	9,587	39,726	31,361	2,352	60,359	5,168	2,652	363,656	129,908	25,982	3,919	2,413	3,047	7,314	.257	.325	.401	.726
6	Giants	4,889	4,638	.513	9,530	323,647	41,175	82,121	14,781	2,080	8,585	38,706	31,889	2,525	61,703	5,337	2,643	364,686	126,817	25,446	4,094	2,531	3,487	7,084	.254	.323	.392	.715
7	Reds	4,846	4,676	.509	9,530	324,062	42,500	83,230	15,603	1,873	9,383	40,046	31,813	2,756	64,365	7,287	2,908	365,007	130,728	26,859	3,820	2,556	3,112	6,823	.257	.326	.403	.730
8	Astros	4,830	4,695	.507	9,528	323,597	41,151	82,858	15,382	2,044	8,174	38,766	30,982	2,777	60,217	7,025	3,022	363,747	126,850	25,600	3,780	2,611	3,024	7,033	.256	.324	.392	.716
9	Athletics	4,829	4,691	.507	9,521	322,177	42,318	80,828	14,683	1,599	9,394	39,847	33,262	2,761	61,791	6,713	2,820	363,530	126,891	25,676	2,646	2,684	1,962	7,176	.251	.324	.394	.718
10	Orioles	4,823	4,676	.508	9,503	324,241	42,752	83,437	15,184	1,434	10,144	40,547	31,702	2,676	58,988	4,934	2,301	363,814	131,921	26,762	2,533	2,662	2,211	7,598	.257	.326	.407	.733
11	Phillies	4,759	4,763	.500	9,527	324,573	41,632	82,725	15,392	2,206	8,721	39,223	32,021	2,653	63,892	6,178	2,441	365,307	128,692	26,319	3,494	2,566	3,235	6,714	.255	.324	.396	.721
12	Guardians	4,728	4,774	.498	9,505	324,385	42,784	84,510	15,381	1,657	9,061	40,390	31,208	2,701	57,416	6,103	2,921	363,942	130,388	26,099	2,812	2,836	2,175	7,469	.261	.328	.402	.730
13	Angels	4,726	4,797	.496	9,525	323,333	41,398	82,924	14,421	1,686	8,670	38,977	30,070	2,689	58,779	5,867	2,973	361,908	126,727	24,777	3,212	2,604	2,334	7,389	.256	.323	.392	.714
14	Twins	4,721	4,797	.496	9,523	326,330	43,053	85,906	15,959	2,099	8,417	40,536	30,289	2,783	58,170	5,171	2,625	364,658	131,314	26,475	2,519	2,737	2,327	7,752	.263	.329	.402	.731
15	Mets	4,695	4,821	.493	9,522	322,222	39,612	80,760	14,600	1,709	8,228	37,327	30,945	2,726	61,853	5,737	2,603	362,234	123,462	24,537	3,831	2,510	3,033	7,074	.251	.319	.383	.702
16	Tigers	4,654	4,863	.489	9,521	324,854	42,728	83,792	14,777	2,148	9,810	40,487	31,052	2,501	61,616	4,573	2,492	363,491	132,295	26,735	2,454	2,630	2,053	7,304	.258	.325	.407	.732
17	White Sox	4,649	4,861	.489	9,520	323,576	41,856	83,519	14,616	1,830	9,104	39,599	29,486	2,795	58,230	5,808	2,851	361,571	129,107	25,550	3,020	2,694	2,089	7,331	.258	.323	.399	.722
18	Cubs	4,644	4,868	.488	9,525	324,615	41,585	82,951	15,043	2,001	9,165	39,199	30,552	2,616	62,552	5,153	2,588	364,091	129,491	26,209	3,823	2,485	2,982	6,969	.256	.322	.399	.721
19	Pirates	4,632	4,879	.487	9,520	325,039	40,524	83,843	15,463	2,355	7,798	38,222	28,653	2,852	61,898	6,106	2,849	363,002	127,410	25,616	3,796	2,662	3,158	6,884	.258	.321	.392	.713
20	Rangers	4,597	4,913	.483	9,515	325,228	43,356	84,339	15,141	1,746	9,664	40,997	30,816	2,599	61,284	5,636	2,687	364,015	131,964	26,551	2,696	2,676	2,125	7,299	.259	.326	.406	.732
21	Brewers	4,327	4,548	.488	8,879	301,399	39,479	77,186	14,388	1,755	8,695	37,401	29,006	2,706	58,821	5,968	2,728	338,686	121,169	24,838	3,161	2,414	2,158	6,606	.256	.325	.402	.727
22	Nationals	4,282	4,589	.483	8,875	300,171	37,182	76,167	14,689	1,788	7,593	34,946	28,227	2,618	57,098	6,540	2,772	337,176	117,211	24,070	3,877	2,283	2,880	6,491	.254	.321	.390	.712
23	Royals	4,229	4,639	.477	8,870	303,388	38,800	79,670	14,894	2,284	6,998	36,618	25,979	2,456	52,045	7,081	2,893	336,854	120,126	24,176	2,365	2,666	1,865	6,773	.263	.323	.396	.719
24	Padres	4,150	4,729	.467	8,881	300,213	35,986	74,866	13,249	1,757	7,247	33,841	28,581	2,122	59,384	6,000	2,603	336,869	113,370	22,253	3,709	2,244	2,685	6,496	.249	.317	.378	.695
25	Blue Jays	3,777	3,806	.498	7,586	259,903	35,059	67,582	13,507	1,491	8,239	33,253	24,098	2,423	48,869	4,568	1,962	290,043	108,788	23,237	1,497	2,122	1,397	5,916	.260	.326	.419	.745