Since 2001, the New York Yankees have the most wins by a team, with 2,293 wins.

Interpreted as:

MLB teams by most regular-season wins since 2001

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,293	1,652	.581	3,947	134,718	20,042	35,112	6,616	483	5,430	19,207	14,605	1,570	29,317	2,445	750	152,580	58,984	12,529	583	1,104	766	3,165	.261	.337	.438	.775
2	Dodgers	2,246	1,702	.569	3,948	134,087	18,292	34,510	6,777	676	4,430	17,457	13,465	1,488	28,967	2,304	831	151,312	55,929	11,883	1,213	1,059	1,052	2,923	.257	.330	.417	.747
3	Cardinals	2,162	1,783	.548	3,945	134,049	18,325	35,017	6,909	577	4,255	17,445	12,900	1,603	28,039	1,893	789	150,979	55,845	11,741	1,333	1,094	1,082	3,077	.261	.331	.417	.748
4	Red Sox	2,149	1,798	.544	3,947	137,059	20,122	36,819	8,221	629	4,664	19,164	13,812	1,470	29,459	2,144	696	153,979	60,290	13,514	459	1,179	936	3,138	.269	.339	.440	.779
5	Braves	2,133	1,811	.541	3,945	134,651	18,273	34,815	6,970	594	4,483	17,477	13,149	1,285	30,022	1,891	746	151,346	56,422	12,047	1,275	986	1,027	3,023	.259	.328	.419	.747
6	Phillies	2,050	1,897	.519	3,947	134,869	18,190	34,360	6,871	771	4,467	17,367	13,283	1,496	30,437	2,552	680	151,769	56,174	12,109	1,140	981	1,103	2,717	.255	.326	.417	.743
7	Guardians	2,044	1,901	.518	3,945	134,211	18,200	34,386	7,182	615	4,233	17,366	13,000	1,557	28,867	2,399	859	150,712	55,497	12,030	803	1,141	763	2,941	.256	.326	.414	.740
8	Astros	2,044	1,902	.518	3,947	134,180	17,956	34,481	6,907	596	4,481	17,128	12,544	1,486	28,840	2,233	878	150,342	56,023	11,984	1,095	1,037	771	3,111	.257	.325	.418	.743
9	Giants	2,036	1,909	.516	3,946	134,147	17,063	34,048	6,845	825	3,782	16,235	12,533	1,290	28,565	1,756	733	150,324	53,889	11,452	1,253	1,101	1,188	3,061	.254	.321	.402	.723
10	Angels	2,024	1,924	.513	3,948	134,494	17,997	34,693	6,604	632	4,238	17,124	11,887	1,451	27,933	2,651	1,023	149,706	55,275	11,474	779	1,095	848	3,019	.258	.323	.411	.733
11	Athletics	2,015	1,932	.511	3,947	134,199	17,741	33,387	6,929	566	4,306	16,908	13,429	1,412	29,138	1,914	624	150,620	54,366	11,801	518	1,062	588	3,076	.249	.321	.405	.726
12	Cubs	1,996	1,950	.506	3,947	134,079	17,766	33,978	6,864	711	4,468	16,932	12,827	1,547	30,985	2,029	823	150,661	55,668	12,043	1,240	968	910	2,888	.253	.324	.415	.739
13	Blue Jays	1,988	1,959	.504	3,947	134,965	18,607	34,783	7,291	565	4,779	17,777	12,665	1,421	28,488	1,893	701	150,673	57,541	12,635	553	1,069	574	3,163	.258	.326	.426	.752
14	Twins	1,985	1,964	.503	3,949	135,260	18,205	35,043	7,067	732	4,149	17,268	12,569	1,409	29,025	2,085	842	150,993	56,021	11,948	675	1,080	728	3,049	.259	.326	.414	.740
15	Brewers	1,984	1,964	.503	3,948	133,388	17,646	33,550	6,731	660	4,548	16,847	12,952	1,649	32,024	2,717	900	150,119	55,245	11,939	1,184	946	884	2,957	.252	.323	.414	.737
16	Mariners	1,974	1,974	.500	3,948	134,593	17,190	33,915	6,380	558	4,143	16,358	12,193	1,498	29,952	2,537	891	150,015	53,840	11,081	725	1,006	755	2,817	.252	.319	.400	.719
17	Rays	1,967	1,980	.498	3,947	134,025	17,575	33,839	6,804	769	4,216	16,742	12,712	1,557	31,239	3,060	1,093	149,970	54,829	11,789	618	1,058	622	2,691	.252	.322	.409	.731
18	Mets	1,965	1,981	.498	3,946	133,741	17,261	33,685	6,660	644	4,175	16,492	12,783	1,618	29,273	2,428	776	150,358	54,158	11,479	1,228	988	1,025	2,927	.252	.322	.405	.727
19	Rangers	1,947	2,002	.493	3,949	135,483	19,103	35,136	6,941	635	4,893	18,202	12,206	1,462	29,814	2,453	847	150,930	58,026	12,469	688	1,091	659	2,781	.259	.325	.428	.753
20	Diamondbacks	1,917	2,031	.486	3,948	134,575	17,931	34,136	7,088	959	4,205	17,106	13,112	1,311	30,312	2,278	809	151,289	55,757	12,252	1,187	1,104	984	2,825	.254	.324	.414	.738
21	Padres	1,902	2,047	.482	3,949	133,152	16,602	32,928	6,375	698	3,790	15,786	12,989	1,239	30,522	2,419	849	149,592	52,069	10,863	1,184	1,028	819	2,838	.247	.318	.391	.709
22	Nationals	1,877	2,069	.476	3,946	133,251	17,108	33,863	6,870	646	3,923	16,270	12,625	1,445	29,346	2,496	943	149,732	53,794	11,439	1,395	1,016	986	3,016	.254	.323	.404	.727
23	White Sox	1,876	2,072	.475	3,948	134,164	17,520	34,240	6,456	535	4,541	16,806	11,353	1,503	29,300	2,154	953	148,831	55,389	11,532	834	977	526	3,040	.255	.318	.413	.731
24	Reds	1,859	2,089	.471	3,949	133,697	17,485	33,476	6,626	583	4,494	16,681	12,951	1,667	31,557	2,491	934	150,606	54,750	11,703	1,344	947	882	2,775	.250	.322	.410	.732
25	Tigers	1,849	2,094	.469	3,943	135,014	17,520	35,017	6,697	933	4,072	16,764	11,524	1,228	29,968	1,773	796	149,535	55,796	11,702	697	1,072	659	3,011	.259	.321	.413	.734