Between the 2005 and 2021 seasons, the New York Yankees had the most wins by a team, with 1,524 wins.

Interpreted as:

MLB teams most regular-season wins from 2005 to 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	1,524	1,128	.575	2,652	90,742	13,423	23,845	4,484	359	3,548	12,852	9,604	1,052	19,480	1,578	466	102,569	39,691	8,391	424	747	459	2,103	.263	.338	.437	.775
2	Dodgers	1,488	1,164	.561	2,652	89,987	12,066	23,221	4,564	467	2,804	11,480	9,142	984	19,466	1,510	584	101,712	37,131	7,835	918	681	752	2,036	.258	.331	.413	.743
3	Cardinals	1,457	1,192	.550	2,649	89,921	12,141	23,493	4,614	400	2,752	11,547	8,638	1,053	18,795	1,146	523	101,261	37,163	7,766	947	702	767	2,132	.261	.331	.413	.744
4	Red Sox	1,455	1,197	.549	2,652	92,085	13,537	24,804	5,487	417	3,112	12,861	9,493	927	19,518	1,415	440	103,635	40,461	9,016	330	800	655	2,160	.269	.341	.439	.780
5	Angels	1,400	1,252	.528	2,652	90,460	12,213	23,520	4,542	415	2,804	11,628	8,072	865	18,241	1,776	678	100,663	37,304	7,761	520	746	606	2,130	.260	.324	.412	.736
6	Indians	1,383	1,267	.522	2,650	90,249	12,296	23,249	4,937	401	2,883	11,737	8,928	1,009	19,916	1,541	522	101,496	37,637	8,221	542	768	494	1,983	.258	.329	.417	.746
7	Braves	1,377	1,273	.520	2,650	90,323	11,962	23,225	4,695	409	2,779	11,429	8,898	836	20,245	1,206	504	101,668	37,075	7,883	977	634	753	2,049	.257	.327	.410	.738
8	Rays	1,375	1,278	.518	2,653	89,978	11,957	22,737	4,555	549	2,982	11,389	8,936	1,058	21,337	1,942	733	101,142	37,336	8,086	423	747	445	1,842	.253	.325	.415	.740
9	Athletics	1,368	1,283	.516	2,651	90,239	11,967	22,521	4,653	406	2,814	11,379	9,090	901	19,357	1,300	431	101,299	36,428	7,873	339	730	358	2,101	.250	.322	.404	.726
10	Brewers	1,357	1,296	.511	2,653	89,669	11,895	22,679	4,606	461	3,142	11,361	8,548	1,126	21,366	1,714	582	100,843	37,633	8,209	863	637	639	1,978	.253	.324	.420	.743
11	Phillies	1,344	1,308	.507	2,652	90,575	11,998	22,889	4,524	545	2,922	11,431	8,736	1,044	20,378	1,605	420	101,832	37,269	7,991	848	629	788	1,813	.253	.324	.411	.735
12	Giants	1,339	1,312	.505	2,651	90,397	11,088	23,054	4,630	599	2,279	10,524	7,831	769	18,874	1,272	532	100,606	35,719	7,508	895	714	712	2,102	.255	.317	.395	.713
13	Cubs	1,332	1,318	.503	2,651	90,165	11,765	22,898	4,673	478	2,919	11,189	8,507	1,072	20,923	1,205	571	101,168	37,284	8,070	826	598	638	1,998	.254	.324	.414	.737
14	Blue Jays	1,328	1,324	.501	2,652	90,495	12,424	23,165	4,879	354	3,327	11,873	8,534	866	19,211	1,256	462	101,021	38,733	8,560	410	716	362	2,113	.256	.324	.428	.752
15	Rangers	1,325	1,328	.499	2,653	90,913	12,729	23,707	4,699	447	3,169	12,103	8,085	971	20,042	1,722	602	101,232	38,807	8,315	531	732	447	1,942	.261	.325	.427	.752
16	Mets	1,323	1,329	.499	2,652	90,094	11,580	22,808	4,564	478	2,742	11,061	8,639	977	19,718	1,665	555	101,273	36,554	7,784	890	673	749	1,945	.253	.323	.406	.729
17	Astros	1,317	1,334	.497	2,652	90,102	11,762	23,014	4,626	406	2,920	11,215	8,230	926	19,684	1,575	636	100,696	37,212	7,952	750	688	486	2,088	.255	.322	.413	.735
18	Nationals	1,313	1,337	.495	2,650	89,730	11,707	22,933	4,624	438	2,752	11,143	8,790	991	20,315	1,511	570	101,179	36,689	7,814	967	701	693	2,013	.256	.326	.409	.735
19	Twins	1,307	1,347	.492	2,654	90,953	12,191	23,611	4,672	504	2,687	11,572	8,497	819	19,159	1,347	531	101,495	37,352	7,863	487	739	529	2,063	.260	.326	.411	.737
20	White Sox	1,300	1,352	.490	2,652	90,305	11,729	23,196	4,275	398	3,030	11,246	7,602	1,064	19,944	1,482	697	100,184	37,357	7,703	550	663	382	2,077	.257	.320	.414	.733
21	Tigers	1,296	1,352	.489	2,648	91,228	12,145	24,244	4,688	604	2,820	11,629	7,859	792	19,917	1,122	491	101,066	38,600	8,112	479	708	513	2,147	.266	.327	.423	.750
22	Reds	1,266	1,386	.477	2,653	89,965	11,751	22,699	4,489	384	3,078	11,226	8,746	1,054	20,732	1,555	613	101,427	37,190	7,951	1,001	661	661	1,879	.252	.324	.413	.737
23	Diamondbacks	1,265	1,387	.477	2,652	90,569	11,837	22,883	4,839	655	2,781	11,292	8,725	841	21,047	1,477	531	101,628	37,375	8,275	797	696	689	1,888	.253	.322	.413	.734
24	Mariners	1,256	1,396	.474	2,652	90,354	11,066	22,585	4,246	383	2,717	10,522	7,613	873	19,842	1,506	590	99,960	35,748	7,346	504	616	483	1,898	.250	.312	.396	.708
25	Padres	1,252	1,401	.472	2,653	89,232	10,786	21,734	4,237	511	2,526	10,253	8,438	819	21,328	1,679	585	100,047	34,571	7,274	893	665	585	1,850	.244	.313	.387	.700