Between the 2000 and 2022 seasons, the New York Yankees lost the fewest games by a team, with 1,510 losses.

Interpreted as:

MLB teams with least regular-season loses 2000 to 2022

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	1,510	2,110	.417	3,622	.583	124,030	18,576	32,723	6,191	458	4,905	17,788	13,368	1,476	26,108	2,222	704	140,450	54,545	11,554	569	1,007	717	2,938	.264	.340	.440	.780
2	Dodgers	1,583	2,041	.437	3,624	.563	123,041	16,517	31,688	6,190	637	3,915	15,730	12,307	1,334	26,002	2,070	800	138,864	50,897	10,742	1,251	931	999	2,747	.258	.329	.414	.743
3	Cardinals	1,596	2,025	.441	3,621	.559	123,077	17,132	32,428	6,383	560	3,968	16,297	12,049	1,473	25,327	1,698	755	138,979	51,835	10,911	1,357	1,023	1,071	2,865	.263	.334	.421	.755
4	Red Sox	1,637	1,986	.452	3,623	.548	125,988	18,605	34,067	7,563	588	4,269	17,713	12,926	1,296	26,117	1,792	618	141,789	55,613	12,420	468	1,111	907	2,926	.270	.342	.441	.783
5	Braves	1,661	1,959	.459	3,621	.541	123,554	16,708	32,080	6,435	563	3,952	15,944	12,146	1,168	26,911	1,756	730	139,117	51,497	10,950	1,336	913	1,020	2,805	.260	.329	.417	.746
6	Athletics	1,711	1,911	.472	3,622	.528	123,469	16,727	31,031	6,449	533	3,959	15,925	12,686	1,282	25,893	1,627	554	138,914	50,423	10,941	479	998	583	2,876	.251	.325	.408	.733
7	Angels	1,726	1,898	.476	3,624	.524	123,902	16,814	32,485	6,226	608	3,852	16,008	11,011	1,246	24,390	2,451	967	137,974	51,483	10,686	793	1,022	838	2,813	.262	.326	.416	.742
8	Giants	1,728	1,893	.477	3,622	.523	123,419	15,916	31,748	6,388	798	3,484	15,140	11,650	1,142	25,273	1,642	710	138,517	50,184	10,670	1,277	1,029	1,200	2,858	.257	.325	.407	.731
9	Guardians	1,744	1,878	.482	3,622	.518	123,761	17,137	32,184	6,710	580	3,977	16,342	12,254	1,406	26,242	2,084	777	139,263	51,985	11,267	786	1,056	690	2,778	.260	.331	.420	.751
10	Astros	1,772	1,851	.489	3,624	.511	123,163	16,641	31,767	6,405	582	4,136	15,873	11,748	1,359	26,251	2,062	846	138,354	51,744	11,123	1,110	974	768	2,885	.258	.327	.420	.747
11	Phillies	1,789	1,834	.494	3,623	.506	123,788	16,540	31,479	6,331	734	3,981	15,761	12,312	1,349	27,366	2,241	624	139,511	51,221	11,046	1,168	894	1,081	2,520	.254	.326	.414	.740
12	Blue Jays	1,809	1,814	.499	3,623	.501	124,163	17,253	32,155	6,753	528	4,488	16,487	11,611	1,269	25,879	1,734	660	138,553	53,428	11,769	529	981	549	2,905	.259	.326	.430	.757
13	Twins	1,810	1,815	.499	3,625	.501	124,464	16,755	32,576	6,570	714	3,658	15,889	11,563	1,163	25,714	1,910	812	138,876	51,548	10,942	668	1,018	721	2,853	.262	.328	.414	.742
14	Mets	1,810	1,812	.500	3,622	.500	122,897	15,817	31,138	6,179	609	3,727	15,080	11,856	1,377	26,272	2,123	767	138,296	49,716	10,515	1,254	912	1,017	2,720	.253	.324	.405	.728
15	White Sox	1,815	1,809	.501	3,624	.499	123,549	16,703	32,110	6,048	536	4,288	16,004	10,674	1,412	26,069	2,012	919	137,414	52,094	10,872	833	946	519	2,834	.260	.324	.422	.745
16	Cubs	1,819	1,803	.502	3,623	.498	123,216	16,182	31,316	6,347	646	4,062	15,401	11,789	1,408	28,075	1,678	761	138,565	51,141	11,055	1,287	865	914	2,746	.254	.324	.415	.739
17	Mariners	1,822	1,802	.503	3,624	.497	123,758	15,897	31,523	5,936	550	3,708	15,123	11,305	1,230	26,351	2,240	852	137,997	49,683	10,194	746	958	733	2,643	.255	.321	.401	.722
18	Rays	1,842	1,780	.509	3,622	.491	123,160	16,130	31,206	6,288	728	3,819	15,363	11,795	1,389	27,959	2,618	997	137,967	50,407	10,835	638	985	615	2,512	.253	.323	.409	.733
19	Brewers	1,849	1,775	.510	3,625	.490	122,583	16,075	30,844	6,257	618	4,217	15,367	11,820	1,533	29,132	2,279	821	138,005	50,988	11,092	1,197	872	882	2,745	.252	.323	.416	.739
20	Rangers	1,856	1,769	.512	3,625	.488	124,621	17,703	32,690	6,480	622	4,482	16,853	11,211	1,330	26,709	2,212	817	138,893	53,860	11,584	709	1,022	642	2,651	.262	.327	.432	.760
21	Diamondbacks	1,875	1,749	.517	3,624	.483	123,664	16,300	31,414	6,548	884	3,793	15,543	11,993	1,147	27,459	1,970	758	138,927	51,109	11,225	1,141	982	972	2,597	.254	.323	.413	.737
22	Nationals	1,886	1,736	.521	3,622	.479	122,468	15,799	31,317	6,376	609	3,654	15,031	11,779	1,266	26,674	2,072	841	137,854	49,873	10,639	1,409	932	1,011	2,797	.256	.325	.407	.732
23	Padres	1,912	1,713	.527	3,625	.473	122,361	15,140	30,199	5,868	685	3,400	14,392	11,970	1,114	28,150	2,187	812	137,521	47,637	9,953	1,125	951	817	2,591	.247	.317	.389	.707
24	Reds	1,922	1,702	.530	3,626	.470	123,060	16,112	31,087	6,153	530	4,155	15,388	11,931	1,501	28,178	2,089	849	138,732	50,765	10,838	1,351	889	912	2,619	.253	.324	.413	.737
25	Marlins	1,935	1,685	.535	3,620	.465	122,979	15,281	31,295	6,110	708	3,388	14,494	10,968	1,356	28,016	2,267	872	137,463	48,985	10,206	1,267	893	893	2,679	.254	.320	.398	.719