Between the 1900 and 1909 seasons, the Pittsburgh Pirates had the most wins by a team, with 938 wins.

Interpreted as:

MLB teams with most regular-season wins 1900s

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Pirates	938	538	.636	1,494	50,241	6,986	13,445	1,795	925	225	5,698	4,014	476	4,493	1,948	56,229	17,765	2,945	1,498	.268	.328	.354	.681
2	Cubs	879	592	.598	1,502	49,666	6,247	12,627	1,735	593	172	4,951	3,904	484	4,945	2,292	55,799	16,064	2,500	1,745	.254	.315	.323	.638
3	Giants	823	645	.561	1,501	49,036	6,385	12,773	1,742	555	221	5,196	4,359	670	4,792	2,308	55,532	16,288	2,518	1,467	.260	.329	.332	.661
4	White Sox	744	575	.564	1,353	44,230	5,404	10,707	1,503	493	104	4,376	3,801	452	4,642	1,946	50,238	13,508	2,100	1,755	.242	.309	.305	.614
5	Athletics	734	568	.564	1,327	44,415	5,582	11,460	1,956	581	256	4,701	3,141	367	4,784	1,478	49,302	15,346	2,793	1,379	.258	.312	.346	.658
6	Phillies	709	752	.485	1,480	49,186	5,920	12,513	1,772	614	156	4,856	3,906	473	5,054	1,690	55,096	15,981	2,542	1,531	.254	.315	.325	.640
7	Reds	705	769	.478	1,503	50,099	6,236	12,887	1,670	825	232	5,224	3,806	438	5,141	1,767	55,833	16,903	2,727	1,490	.257	.315	.337	.653
8	Naps	697	632	.524	1,351	45,413	5,458	11,808	1,895	673	172	4,536	2,715	424	5,347	1,552	49,981	15,565	2,740	1,429	.260	.308	.343	.651
9	Red Sox	691	634	.522	1,344	45,372	5,409	11,513	1,541	767	247	4,554	2,941	435	4,729	1,257	50,022	15,329	2,555	1,274	.254	.305	.338	.643
10	Tigers	683	632	.519	1,342	44,538	5,414	11,424	1,568	632	146	4,398	3,115	385	4,622	1,550	49,519	14,694	2,346	1,481	.257	.311	.330	.641
11	Superbas	649	809	.445	1,483	48,879	5,551	12,155	1,611	642	223	4,607	3,689	445	5,561	1,811	54,376	15,719	2,476	1,363	.249	.307	.322	.629
12	Browns	599	721	.454	1,348	45,034	4,832	11,088	1,460	517	153	3,949	3,073	390	4,897	1,335	49,782	14,041	2,130	1,285	.246	.300	.312	.612
13	Doves	587	877	.401	1,490	49,526	5,292	12,026	1,457	482	225	4,326	3,695	470	5,106	1,445	54,977	15,122	2,164	1,286	.243	.302	.305	.607
14	Cardinals	580	888	.395	1,489	49,676	5,543	12,503	1,437	662	196	4,440	3,527	533	5,532	1,671	54,956	15,852	2,295	1,220	.252	.308	.319	.627
15	Highlanders	520	518	.501	1,058	34,908	4,059	8,754	1,152	469	129	3,323	2,334	396	3,854	1,339	38,722	11,231	1,750	1,084	.251	.305	.322	.627
16	Senators	480	833	.366	1,343	44,375	4,711	10,699	1,547	583	184	3,901	2,908	441	5,113	1,460	48,914	13,964	2,314	1,190	.241	.294	.315	.609
17	Orioles	118	153	.435	276	9,349	1,476	2,666	381	218	57	1,231	786	106	797	396	10,459	3,654	656	218	.285	.347	.391	.738