Between the 1920 and 1929 seasons, the New York Yankees had the most wins by a team, with 933 wins.

Interpreted as:

MLB teams with most regular-season wins 1920s

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Yankees	933	602	.608	1,540	52,872	8,487	15,385	2,584	802	1,211	7,824	5,462	281	5,379	695	60,413	23,206	4,597	1,798	.291	.360	.439	.799
2	Giants	890	639	.582	1,536	53,651	8,005	15,637	2,448	703	931	7,316	4,440	308	4,398	965	59,829	22,284	4,082	1,430	.291	.349	.415	.764
3	Pirates	877	656	.572	1,543	53,754	7,836	15,817	2,426	1,042	486	7,090	4,219	290	3,615	1,268	59,986	21,785	3,954	1,723	.294	.349	.405	.754
4	Cardinals	822	712	.536	1,541	53,742	7,870	15,649	2,739	830	848	7,204	4,488	294	4,561	885	60,210	22,592	4,417	1,686	.291	.349	.420	.769
5	Cubs	807	728	.526	1,543	52,782	7,363	14,948	2,527	597	726	6,700	4,640	318	4,741	1,030	59,616	20,847	3,850	1,876	.283	.345	.395	.740
6	Reds	798	735	.521	1,541	52,340	6,794	14,856	2,261	908	338	6,120	4,044	317	3,426	1,042	58,641	19,947	3,507	1,940	.284	.339	.381	.720
7	Senators	792	735	.519	1,541	52,661	7,411	14,995	2,467	849	387	6,616	5,010	435	4,227	1,170	60,077	20,321	3,703	1,971	.285	.352	.386	.738
8	Indians	786	749	.512	1,538	52,991	7,773	15,630	3,111	693	410	7,052	5,035	388	3,654	746	60,476	21,357	4,214	2,062	.295	.360	.403	.763
9	Athletics	770	754	.505	1,533	52,482	7,340	14,796	2,634	663	757	6,650	4,644	360	4,820	674	59,342	21,027	4,054	1,856	.282	.344	.401	.745
10	Robins	765	768	.499	1,541	53,197	6,910	14,838	2,292	750	585	6,275	4,236	252	4,153	725	59,260	20,385	3,627	1,575	.279	.335	.383	.718
11	Browns	762	769	.498	1,541	53,050	7,762	15,385	2,702	752	710	6,952	4,719	333	4,042	884	60,053	21,721	4,164	1,951	.290	.352	.409	.761
12	Tigers	760	778	.494	1,553	53,537	8,260	15,803	2,773	873	527	7,414	5,615	314	4,076	968	61,575	21,903	4,173	2,109	.295	.365	.409	.775
13	White Sox	731	804	.476	1,542	52,439	7,133	14,750	2,630	689	367	6,426	5,132	359	4,257	1,236	60,067	19,859	3,686	2,137	.281	.349	.379	.728
14	Braves	603	928	.394	1,537	52,846	6,267	14,513	2,124	680	352	5,583	3,964	281	4,164	763	58,830	19,053	3,156	1,739	.275	.329	.361	.689
15	Red Sox	595	938	.388	1,542	52,050	6,228	13,840	2,591	639	315	5,630	4,542	354	4,471	761	58,743	18,654	3,545	1,797	.266	.329	.358	.687
16	Phillies	566	962	.370	1,534	53,550	7,078	15,074	2,560	506	944	6,460	4,211	304	5,248	616	59,474	21,478	4,010	1,409	.281	.337	.401	.738