Since 1900, the New York Yankees have the most wins by a team, with 10,812 wins.

Interpreted as:

MLB teams with the most regular-season wins since 1900

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	10,812	8,168	.570	19,068	649,886	92,671	172,534	28,650	5,497	17,329	86,109	68,619	4,930	94,894	11,655	2,802	736,319	264,165	51,476	9,595	3,289	2,836	10,687	.265	.339	.406	.745
2	Giants	10,358	9,067	.533	19,518	664,032	87,333	173,797	28,394	5,649	14,978	80,372	61,909	5,100	96,650	12,555	3,146	745,365	258,423	49,021	11,309	3,015	4,018	10,189	.262	.328	.389	.717
3	Dodgers	10,334	9,091	.532	19,520	663,644	85,079	173,057	28,205	5,721	13,679	78,414	62,279	4,441	97,461	13,407	3,552	745,659	253,741	47,605	12,232	3,063	3,737	9,951	.261	.327	.382	.709
4	Cardinals	10,136	9,287	.522	19,529	667,450	86,901	177,405	30,618	6,412	12,589	79,903	60,708	4,794	95,611	13,490	3,616	747,488	258,614	49,619	11,392	3,144	3,776	10,140	.266	.330	.387	.717
5	Red Sox	9,982	9,293	.518	19,358	662,539	90,402	176,786	33,136	5,600	14,612	83,836	66,836	4,807	95,634	9,638	2,552	748,118	264,958	53,348	10,596	3,340	2,998	11,552	.267	.337	.400	.737
6	Guardians	9,881	9,394	.513	19,366	660,051	87,549	174,722	31,159	5,499	13,923	80,913	62,643	4,838	94,662	11,914	3,390	742,354	258,648	50,581	11,464	3,358	2,545	10,529	.265	.331	.392	.723
7	Cubs	9,806	9,629	.505	19,542	664,459	85,245	172,550	29,643	5,720	14,297	78,322	60,931	4,742	101,910	11,968	3,072	745,458	256,524	49,660	12,415	2,911	3,522	9,964	.260	.325	.386	.711
8	Pirates	9,792	9,628	.504	19,516	666,604	84,828	175,764	29,494	7,428	11,834	77,973	58,254	4,788	96,623	12,657	3,271	744,563	255,616	48,756	11,801	3,116	3,701	10,062	.264	.326	.383	.709
9	Tigers	9,712	9,587	.503	19,392	661,287	89,054	174,705	29,605	6,296	14,585	82,006	65,574	4,450	96,795	11,292	2,938	745,430	260,657	50,486	11,009	3,110	2,448	10,720	.264	.333	.394	.727
10	Reds	9,684	9,759	.498	19,538	663,544	84,287	172,422	29,413	6,017	13,752	77,796	60,119	4,841	99,640	13,975	3,410	743,557	255,125	49,182	12,013	3,040	3,647	9,721	.260	.324	.384	.709
11	White Sox	9,611	9,650	.499	19,364	655,643	84,098	170,229	28,220	5,551	12,294	77,305	62,117	5,249	92,132	13,632	3,484	738,600	246,433	46,065	12,368	3,223	2,461	10,522	.260	.327	.376	.703
12	Braves	9,519	9,874	.491	19,504	663,227	82,450	170,846	28,136	4,853	14,206	76,142	60,195	4,429	97,268	10,518	3,067	742,727	251,306	47,195	11,995	2,881	3,655	10,387	.258	.322	.379	.701
13	Athletics	9,352	9,891	.486	19,330	655,213	85,313	168,656	29,208	5,333	14,149	78,615	64,538	4,734	99,078	12,111	3,207	738,271	250,977	48,690	10,682	3,104	2,272	10,628	.257	.327	.383	.710
14	Twins	9,289	9,979	.482	19,377	661,002	85,194	173,340	29,764	6,334	12,022	78,434	62,374	5,165	94,526	12,016	3,081	741,898	251,838	48,120	10,190	3,167	2,664	10,977	.262	.329	.381	.710
15	Orioles	9,139	10,119	.475	19,368	657,899	83,625	169,761	29,340	4,912	14,439	77,318	63,310	4,479	98,417	10,559	2,785	739,324	252,242	48,691	10,532	3,104	2,576	10,848	.258	.326	.383	.709
16	Phillies	9,109	10,292	.470	19,478	662,958	82,999	171,424	29,888	5,449	13,602	76,472	61,152	4,657	102,301	11,580	2,915	743,030	253,016	48,939	11,245	3,018	3,739	9,866	.259	.324	.382	.706
17	Angels	5,046	5,144	.495	10,193	345,829	44,108	88,478	15,299	1,811	9,228	41,505	32,335	2,827	62,816	6,049	3,101	387,303	135,083	26,338	3,538	2,774	2,484	7,878	.256	.322	.391	.713
18	Astros	5,038	4,990	.502	10,033	340,484	42,791	86,807	15,916	2,173	8,434	40,272	32,368	2,906	62,968	7,149	3,136	382,504	132,371	26,523	4,030	2,716	3,145	7,416	.255	.323	.389	.711
19	Mets	4,850	5,169	.484	10,027	339,231	41,365	84,763	15,144	1,818	8,583	38,950	32,435	2,866	65,008	5,893	2,737	381,145	129,292	25,545	3,989	2,624	3,143	7,465	.250	.318	.381	.699
20	Rangers	4,845	5,331	.476	10,182	347,564	45,795	89,628	15,972	1,892	10,204	43,271	32,909	2,702	65,240	5,952	2,849	388,971	139,996	28,068	2,963	2,833	2,251	7,796	.258	.324	.403	.727
21	Brewers	4,336	4,558	.488	8,898	302,029	39,545	77,323	14,412	1,756	8,712	37,465	29,072	2,714	58,986	5,995	2,734	339,395	121,383	24,880	3,164	2,416	2,159	6,612	.256	.325	.402	.726
22	Nationals	4,289	4,599	.483	8,892	300,726	37,246	76,299	14,722	1,790	7,608	35,006	28,268	2,629	57,223	6,552	2,778	337,790	117,425	24,120	3,880	2,287	2,881	6,505	.254	.321	.390	.712
23	Royals	4,237	4,650	.477	8,889	304,044	38,858	79,842	14,926	2,291	7,005	36,673	26,009	2,464	52,181	7,096	2,899	337,560	120,365	24,222	2,371	2,672	1,868	6,782	.263	.323	.396	.719
24	Padres	4,158	4,739	.467	8,899	300,843	36,071	75,019	13,273	1,761	7,269	33,918	28,633	2,126	59,521	6,007	2,605	337,563	113,621	22,303	3,712	2,249	2,687	6,504	.249	.317	.378	.695
25	Blue Jays	3,787	3,816	.498	7,606	260,580	35,146	67,754	13,539	1,492	8,262	33,336	24,173	2,427	49,014	4,576	1,963	290,810	109,063	23,293	1,503	2,127	1,403	5,933	.260	.326	.419	.745