Randy Johnson had the most games pitched when striking out 12+ batters, with 101 games.

Interpreted as:

most 12 or more strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Randy Johnson R. Johnson	101	1,386	61	19	.763	100	1.91	43	16	0	810.2	517	172	195	56	218	25	1	6	3,140	20	15.39	2.42	6.36	0.62	44.1	6.9	0.91	.317	2.16	5.74
2	Nolan Ryan N. Ryan	95	1,291	64	18	.780	95	1.68	66	18	0	837.0	433	156	184	30	386	19	0	8	3,302	36	13.88	4.15	3.34	0.32	39.1	11.7	0.98	.256	1.98	4.66
3	Pedro Martinez P. Martinez	43	569	29	9	.763	43	1.22	19	7	0	348.0	195	47	54	15	69	12	0	3	1,304	4	14.72	1.78	8.25	0.39	43.6	5.3	0.76	.282	1.40	5.04
4	Sandy Koufax S. Koufax	43	577	38	4	.905	43	1.33	36	14	0	398.2	197	59	69	25	108	2	0	6	1,498	11	13.03	2.44	5.34	0.56	38.5	7.2	0.77	.219	1.56	4.45
5	Chris Sale C. Sale	41	528	24	5	.828	41	1.23	4	1	0	307.1	161	42	46	20	47	9	0	0	1,133	5	15.46	1.38	11.23	0.59	46.6	4.1	0.68	.267	1.35	4.71
6	Curt Schilling C. Schilling	36	466	24	7	.774	36	2.33	8	3	0	278.2	195	72	76	34	43	3	0	0	1,061	6	15.05	1.39	10.84	1.10	43.9	4.1	0.85	.313	2.45	6.30
7	Roger Clemens R. Clemens	35	487	28	3	.903	35	1.03	23	12	0	298.1	184	34	37	9	42	6	0	2	1,106	6	14.69	1.27	11.60	0.27	44.0	3.8	0.76	.311	1.12	5.55
8	Steve Carlton S. Carlton	34	446	25	5	.833	34	2.01	27	6	0	304.1	215	68	71	18	92	4	0	6	1,194	12	13.19	2.72	4.85	0.53	37.4	7.7	1.01	.311	2.10	6.36
9	Sam McDowell S. McDowell	31	414	21	7	.750	31	1.49	22	4	0	278.0	163	46	53	13	116	5	1	6	1,098	8	13.40	3.76	3.57	0.42	37.7	10.6	1.00	.273	1.72	5.28
10	Bob Gibson B. Gibson	30	386	24	6	.800	30	1.53	27	9	0	276.2	174	47	52	7	56	4	0	2	1,051	5	12.56	1.82	6.89	0.23	36.7	5.3	0.83	.279	1.69	5.66
11	Tom Seaver T. Seaver	26	349	20	3	.870	26	1.41	17	7	0	235.2	125	37	37	16	48	3	0	3	878	2	13.33	1.83	7.27	0.61	39.7	5.5	0.73	.236	1.41	4.77
12	Max Scherzer M. Scherzer	25	343	16	2	.889	25	1.24	3	2	0	189.1	100	26	28	14	33	4	0	1	701	1	16.30	1.57	10.39	0.67	48.9	4.7	0.70	.280	1.33	4.75
13	Gerrit Cole G. Cole	24	312	16	0	1.000	24	1.62	2	2	0	166.1	88	30	32	14	19	3	0	0	604	5	16.88	1.03	16.42	0.76	51.7	3.1	0.64	.289	1.73	4.76
14	Clayton Kershaw C. Kershaw	23	299	20	1	.952	23	0.94	7	5	0	181.0	83	19	22	14	15	3	0	0	637	5	14.87	0.75	19.93	0.70	46.9	2.4	0.54	.225	1.09	4.13
15	Justin Verlander J. Verlander	22	281	15	2	.882	22	1.53	4	4	0	164.2	95	28	32	15	27	3	0	0	617	2	15.36	1.48	10.41	0.82	45.5	4.4	0.74	.275	1.75	5.19
16	Bert Blyleven B. Blyleven	22	276	15	4	.789	22	1.37	18	4	0	196.2	127	30	39	7	38	2	0	1	756	3	12.63	1.74	7.26	0.32	36.5	5.0	0.84	.277	1.78	5.81
17	Jacob deGrom J. deGrom	20	261	9	2	.818	20	2.14	1	1	0	138.2	84	33	37	13	20	0	0	2	515	2	16.94	1.30	13.05	0.84	50.7	3.9	0.75	.321	2.40	5.45
18	J.R. Richard	20	258	16	2	.889	20	1.84	15	4	0	175.2	98	36	40	5	59	3	0	3	690	12	13.22	3.02	4.37	0.26	37.4	8.6	0.89	.255	2.05	5.02
19	David Cone D. Cone	19	245	13	3	.813	19	1.50	6	2	0	150.1	96	25	30	7	44	5	0	1	594	10	14.67	2.63	5.57	0.42	41.2	7.4	0.93	.304	1.80	5.75
20	Mickey Lolich M. Lolich	19	254	12	3	.800	19	1.51	13	3	0	173.0	99	29	30	5	44	9	0	1	664	7	13.21	2.29	5.77	0.26	38.3	6.6	0.83	.267	1.56	5.15
21	Jim Maloney J. Maloney	19	249	15	1	.938	19	0.94	12	8	0	172.2	75	18	18	2	69	5	0	1	649	5	12.98	3.60	3.61	0.10	38.4	10.6	0.83	.225	0.94	3.91
22	Bob Feller B. Feller	19	256	16	2	.889	19	1.76	17	4	0	174.0	108	34	38	4	99	5	0		723	4	13.24	5.12	2.59	0.21	35.4	13.7	1.19	.290	1.97	5.59
23	Bob Veale B. Veale	17	219	13	2	.867	17	0.95	11	6	0	152.0	112	16	19	0	54	2	0	6	612	3	12.97	3.20	4.06	0.00	35.8	8.8	1.09	.332	1.13	6.63
24	Corey Kluber C. Kluber	16	211	9	1	.900	16	1.93	0	0	0	121.1	76	26	29	12	18	4	0	2	456	1	15.65	1.34	11.72	0.89	46.3	3.9	0.77	.303	2.15	5.64
25	Yu Darvish Y. Darvish	16	206	9	3	.750	16	1.84	0	0	0	117.1	65	24	24	12	20	1	0	0	439	3	15.80	1.53	10.30	0.92	46.9	4.6	0.72	.265	1.84	4.99