Nolan Ryan had the most games pitched when striking out 4+ batters, with 654 games.

Interpreted as:

most 4 or more strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	654	5,428	306	219	.583	648	2.70	222	61	1	4850.0	3,292	1,456	1,672	257	2,344	129	2	66	19,930	239	10.07	4.35	2.32	0.48	27.2	11.8	1.16	.258	3.10	6.11
2	Roger Clemens R. Clemens	605	4,455	323	142	.695	605	2.84	116	45	0	4360.2	3,554	1,375	1,508	310	1,333	132	0	57	17,730	115	9.19	2.75	3.34	0.64	25.1	7.5	1.12	.282	3.11	7.34
3	Randy Johnson R. Johnson	532	4,694	287	129	.690	526	2.85	97	37	2	3766.0	2,880	1,193	1,350	346	1,244	165	3	33	15,270	92	11.22	2.97	3.77	0.83	30.7	8.1	1.10	.287	3.23	6.88
4	Steve Carlton S. Carlton	532	3,733	293	149	.663	529	2.71	235	47	1	4143.2	3,413	1,249	1,405	270	1,403	37	2	118	16,874	144	8.11	3.05	2.66	0.59	22.1	8.3	1.16	.275	3.05	7.41
5	Bert Blyleven B. Blyleven	508	3,324	250	158	.613	507	2.73	226	57	0	3942.0	3,376	1,194	1,342	289	1,036	118	0	48	15,965	87	7.59	2.37	3.21	0.66	20.8	6.5	1.12	.276	3.06	7.71
6	Don Sutton D. Sutton	484	2,985	245	131	.652	481	2.64	149	47	1	3651.0	2,958	1,071	1,190	261	877	53	2	69	14,645	81	7.36	2.16	3.40	0.64	20.4	6.0	1.05	.258	2.93	7.29
7	Greg Maddux G. Maddux	480	2,820	252	128	.663	480	2.68	92	30	0	3450.1	3,029	1,028	1,162	203	637	89	0	114	13,814	50	7.36	1.66	4.43	0.53	20.4	4.6	1.06	.281	3.03	7.90
8	Gaylord Perry G. Perry	479	2,998	253	153	.623	466	2.47	262	45	2	3859.2	3,211	1,061	1,254	254	947	72	3	98	15,476	101	6.99	2.21	3.17	0.59	19.4	6.1	1.08	.264	2.92	7.49
9	Tom Seaver T. Seaver	471	3,262	253	128	.664	471	2.37	207	53	0	3722.1	2,840	981	1,078	263	1,027	51	0	83	14,796	84	7.89	2.48	3.18	0.64	22.0	6.9	1.04	.253	2.61	6.87
10	Justin Verlander J. Verlander	456	3,270	242	108	.691	456	2.90	25	9	0	3027.1	2,416	977	1,058	301	796	95	0	22	12,180	84	9.72	2.37	4.11	0.89	26.8	6.5	1.06	.274	3.15	7.18
11	Phil Niekro P. Niekro	456	2,670	222	142	.610	446	2.73	200	34	4	3534.2	2,981	1,072	1,252	276	1,106	80	9	50	14,459	150	6.80	2.82	2.41	0.70	18.5	7.6	1.16	.262	3.19	7.59
12	Walter Johnson W. Johnson	453	2,874	292	139	.677	433	1.21	384	90	2	3946.2	2,982		1,005	50	836	140	20		15,442	114	6.55	1.91	3.44	0.11	18.6	5.4	0.97	.254	2.29	6.80
13	CC Sabathia	435	2,812	216	113	.657	435	3.29	35	12	0	2886.1	2,595	1,054	1,155	274	838	99	0	33	11,897	53	8.77	2.61	3.36	0.85	23.6	7.0	1.19	.295	3.60	8.09
14	Fergie Jenkins F. Jenkins	431	2,773	242	136	.640	424	2.78	234	46	1	3414.1	2,896	1,053	1,177	335	685	66	5	73	13,679	49	7.31	1.81	4.05	0.88	20.3	5.0	1.05	.261	3.10	7.63
15	Max Scherzer M. Scherzer	415	3,300	209	92	.694	413	2.89	12	5	0	2667.0	2,074	855	911	291	678	97	0	19	10,659	68	11.14	2.29	4.87	0.98	31.0	6.4	1.03	.283	3.07	7.00
16	Zack Greinke Z. Greinke	409	2,621	196	89	.688	405	2.82	13	4	0	2618.1	2,242	819	888	236	537	57	0	14	10,452	79	9.01	1.85	4.88	0.81	25.1	5.1	1.06	.287	3.05	7.71
17	Bob Gibson B. Gibson	406	2,912	229	131	.636	398	2.56	242	55	0	3324.1	2,667	945	1,076	200	1,059	89	2	94	13,554	84	7.88	2.87	2.75	0.54	21.5	7.8	1.12	.265	2.91	7.22
18	Mike Mussina M. Mussina	396	2,525	222	94	.703	396	3.14	51	21	0	2758.2	2,446	961	1,035	259	566	46	0	21	11,069	46	8.24	1.85	4.46	0.84	22.8	5.1	1.09	.285	3.38	7.98
19	John Smoltz J. Smoltz	393	2,626	180	113	.614	389	2.94	51	16	4	2741.1	2,308	896	982	209	756	41	4	68	11,113	113	8.62	2.48	3.47	0.69	23.6	6.8	1.12	.281	3.22	7.58
20	Clayton Kershaw C. Kershaw	388	2,869	204	80	.718	387	2.33	25	15	0	2549.1	1,879	659	714	205	602	38	1	22	9,967	94	10.13	2.13	4.77	0.72	28.8	6.0	0.97	.268	2.52	6.63
21	Curt Schilling C. Schilling	383	2,852	195	104	.652	373	3.12	81	19	3	2741.1	2,391	950	991	268	544	43	7	27	10,998	59	9.36	1.79	5.24	0.88	25.9	4.9	1.07	.291	3.25	7.85
22	Mickey Lolich M. Lolich	377	2,518	189	123	.606	370	2.85	174	40	0	2882.1	2,444	914	1,024	241	826	70	5	44	11,748	92	7.86	2.58	3.05	0.75	21.4	7.0	1.13	.272	3.20	7.63
23	Jim Bunning J. Bunning	375	2,480	194	101	.658	367	2.50	142	39	1	2891.1	2,323	802	897	243	704	115	4	64	11,649	29	7.72	2.19	3.52	0.76	21.3	6.0	1.05	.257	2.79	7.23
24	Pedro Martinez P. Martinez	372	2,962	200	80	.714	364	2.66	46	17	1	2535.0	1,918	748	825	209	628	121	3	22	10,095	54	10.52	2.23	4.72	0.74	29.3	6.2	1.00	.277	2.93	6.81
25	Bartolo Colon B. Colon	358	2,113	187	96	.661	354	3.42	26	9	0	2349.2	2,209	892	955	255	621	39	0	32	9,696	29	8.09	2.38	3.40	0.98	21.8	6.4	1.20	.293	3.66	8.46