Nolan Ryan had the most games pitched when striking out 9+ batters, with 282 games.

Interpreted as:

most 9 or more strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	282	3,150	162	80	.669	282	1.97	149	48	0	2316.0	1,383	508	594	97	1,041	55	0	30	9,286	116	12.24	4.05	3.03	0.38	33.9	11.2	1.05	.260	2.31	5.37
2	Randy Johnson R. Johnson	251	2,905	165	42	.797	250	2.05	75	30	0	1936.0	1,267	441	498	149	532	74	1	15	7,552	42	13.50	2.47	5.46	0.69	38.5	7.0	0.93	.287	2.32	5.89
3	Roger Clemens R. Clemens	176	1,857	116	29	.800	176	1.97	59	25	0	1390.2	958	305	331	68	335	37	0	13	5,421	40	12.02	2.17	5.54	0.44	34.3	6.2	0.93	.285	2.14	6.20
4	Max Scherzer M. Scherzer	168	1,750	96	26	.787	168	2.16	11	4	0	1164.1	749	280	298	121	223	35	0	11	4,453	21	13.53	1.72	7.85	0.94	39.3	5.0	0.83	.270	2.30	5.79
5	Pedro Martinez P. Martinez	155	1,666	91	32	.740	155	1.74	35	14	0	1175.0	735	227	252	74	254	48	0	10	4,502	24	12.76	1.95	6.56	0.57	37.0	5.6	0.84	.269	1.93	5.63
6	Steve Carlton S. Carlton	139	1,465	95	30	.760	139	2.24	85	15	0	1177.1	898	293	332	65	388	10	0	34	4,741	51	11.20	2.97	3.78	0.50	30.9	8.2	1.09	.296	2.54	6.86
7	Curt Schilling C. Schilling	124	1,335	82	26	.759	124	2.25	34	10	0	960.2	684	240	252	89	152	14	0	7	3,684	19	12.51	1.42	8.78	0.83	36.2	4.1	0.87	.284	2.36	6.41
8	Chris Sale C. Sale	122	1,320	65	26	.714	122	1.93	10	2	0	852.2	538	183	206	62	164	46	0	3	3,278	18	13.93	1.73	8.05	0.65	40.3	5.0	0.82	.282	2.17	5.68
9	Clayton Kershaw C. Kershaw	121	1,244	79	21	.790	121	1.78	15	8	0	870.2	546	172	190	60	146	14	0	3	3,263	25	12.86	1.51	8.52	0.62	38.1	4.5	0.79	.270	1.96	5.64
10	Sandy Koufax S. Koufax	119	1,333	92	18	.836	119	1.62	88	22	0	1052.1	615	190	218	67	291	5	0	19	4,045	32	11.40	2.49	4.58	0.57	33.0	7.2	0.86	.233	1.86	5.26
11	Justin Verlander J. Verlander	112	1,167	74	10	.881	112	2.02	11	6	0	782.2	492	176	191	74	147	22	0	4	2,991	24	13.42	1.69	7.94	0.85	39.0	4.9	0.82	.264	2.20	5.66
12	Tom Seaver T. Seaver	106	1,131	74	18	.804	106	1.63	68	23	0	923.1	584	167	176	55	221	17	0	17	3,530	13	11.02	2.15	5.12	0.54	32.0	6.3	0.87	.251	1.72	5.69
13	Bob Gibson B. Gibson	105	1,123	77	21	.786	105	1.91	83	20	0	943.0	678	200	230	51	244	26	0	22	3,722	20	10.72	2.33	4.60	0.49	30.2	6.6	0.98	.275	2.20	6.47
14	Sam McDowell S. McDowell	103	1,122	59	18	.766	103	1.92	55	14	0	859.0	539	183	221	44	376	21	1	15	3,465	31	11.76	3.94	2.98	0.46	32.4	10.9	1.07	.260	2.32	5.65
15	David Cone D. Cone	92	958	59	14	.808	92	2.25	19	9	0	700.1	501	175	194	51	223	19	0	10	2,814	36	12.31	2.87	4.30	0.66	34.0	7.9	1.03	.288	2.49	6.44
16	Jacob deGrom J. deGrom	88	926	42	19	.689	88	1.84	2	1	0	592.2	379	121	138	47	106	4	0	5	2,235	14	14.06	1.61	8.74	0.71	41.4	4.7	0.82	.288	2.10	5.76
17	Gerrit Cole G. Cole	88	942	53	10	.841	88	2.12	5	4	0	580.2	363	137	156	58	105	10	0	1	2,196	19	14.60	1.63	8.97	0.90	42.9	4.8	0.81	.282	2.42	5.63
18	Yu Darvish Y. Darvish	88	903	45	23	.662	88	2.21	1	1	0	598.2	377	147	151	63	140	19	0	1	2,302	21	13.58	2.10	6.45	0.95	39.2	6.1	0.86	.267	2.27	5.67
19	Bert Blyleven B. Blyleven	86	891	49	25	.662	86	1.85	57	13	0	736.0	539	151	179	39	160	21	0	5	2,878	12	10.90	1.96	5.57	0.48	31.0	5.6	0.95	.283	2.19	6.59
20	Mickey Lolich M. Lolich	82	865	56	16	.778	82	1.85	56	15	0	710.0	506	146	167	41	204	28	0	7	2,826	21	10.96	2.59	4.24	0.52	30.6	7.2	1.00	.275	2.12	6.41
21	Gaylord Perry G. Perry	78	804	47	21	.691	77	1.90	54	8	0	712.1	511	150	177	41	174	22	0	17	2,804	16	10.16	2.20	4.62	0.52	28.7	6.2	0.96	.267	2.24	6.46
22	CC Sabathia	77	761	55	9	.859	77	1.99	15	5	0	571.0	434	126	140	36	132	15	0	4	2,246	7	11.99	2.08	5.77	0.57	33.9	5.9	0.99	.306	2.21	6.84
23	Jim Bunning J. Bunning	77	787	48	12	.800	77	1.88	40	9	0	662.0	489	138	158	45	143	21	0	10	2,618	4	10.70	1.94	5.50	0.61	30.1	5.5	0.95	.274	2.15	6.65
24	Felix Hernandez F. Hernandez	76	757	43	14	.754	76	1.62	11	5	0	565.2	362	102	113	23	110	17	0	1	2,153	34	12.04	1.75	6.88	0.37	35.2	5.1	0.83	.272	1.80	5.76
25	Bob Feller B. Feller	75	804	62	10	.861	75	1.70	67	16	0	671.2	430	127	143	17	298	10	0		2,717	14	10.77	3.99	2.70	0.23	29.6	11.0	1.08	.260	1.92	5.76