Ty Cobb has the most career at-bats by a player against a team, with 1,660 at-bats against the Yankees.

Interpreted as:

most at bats by a player against one team

	NAME	AB	OPP	G	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Ty Cobb T. Cobb	1,660	Yankees	443	342	619	117	53	23		176	11		103		1,884	911	193	37				.373	.436	.549	.985
2	Ty Cobb T. Cobb	1,657	Red Sox	437	316	615	97	53	13		175	17		139		1,891	857	163	42				.371	.436	.517	.954
3	Ty Cobb T. Cobb	1,654	Indians	432	319	580	105	34	15		160	14		135		1,858	798	154	35				.351		.482
4	Ty Cobb T. Cobb	1,621	White Sox	427	301	575	96	30	11		177	13		108		1,853	764	137	42				.355	.422	.471	.894
5	Ty Cobb T. Cobb	1,597	Browns	429	323	568	96	45	26		190	13		135		1,854	832	167	54				.356	.428	.521	.949
6	Ty Cobb T. Cobb	1,592	Senators	434	302	605	97	38	16		194	13		145		1,841	826	151	42				.380	.451	.519	.970
7	Stan Musial S. Musial	1,574	Reds	428	275	500	92	22	66	275	224	7	94	9	4	1,815	834	180	4	6	24	36	.318	.404	.530	.934
8	Stan Musial S. Musial	1,572	Braves	427	258	515	108	25	60	259	204	5	105	10	8	1,787	853	193	4	2	15	36	.328	.406	.543	.949
9	Ty Cobb T. Cobb	1,552	Athletics	397	316	590	104	44	13		170	9		131		1,774	821	161	43				.380	.444	.529	.973
10	Stan Musial S. Musial	1,550	Cubs	422	252	492	104	19	67	286	217	4	106	11	4	1,784	835	190	1	12	12	36	.317	.400	.539	.939
11	Stan Musial S. Musial	1,547	Phillies	417	297	522	116	35	54	261	197	8	110	12	4	1,765	870	205	8	5	13	30	.337	.414	.562	.976
12	Stan Musial S. Musial	1,546	Pirates	426	275	526	108	27	58	253	238	5	79	14	4	1,806	862	193	8	9	21	31	.340	.428	.558	.985
13	Stan Musial S. Musial	1,530	Dodgers	432	299	522	108	30	74	271	249	13	90	13	1	1,805	912	212	5	8	15	39	.341	.436	.596	1.032
14	Tristram Speaker T. Speaker	1,517	Yankees	410	284	499	120	24	27		185	13		66		1,762	748	171	47				.329	.406	.493	.899
15	Pete Rose P. Rose	1,513	Braves	381	263	486	80	15	25	162	196	12	98	30	18	1,737	671	120	9	7	20	22	.321	.402	.443	.845
16	Tristram Speaker T. Speaker	1,506	Tigers	398	278	511	110	32	17		209	14		77		1,763	736	159	34				.339	.425	.489	.913
17	Stan Musial S. Musial	1,494	Giants	417	272	504	82	18	89	312	245	11	100	8	6	1,764	889	189	6	8	24	38	.337	.432	.595	1.027
18	Tristram Speaker T. Speaker	1,477	White Sox	405	240	511	119	32	11		189	10		46		1,712	727	162	36				.346	.424	.492	.916
19	Rabbit Maranville R. Maranville	1,475	Giants	396	177	363	53	21	5		114	7	112	30		1,638	473	79	42				.246	.303	.321	.624
20	Eddie Collins E. Collins	1,462	Indians	407	253	491	73	28	2		220	10		98		1,783	626	103	91				.336	.426	.428	.854
21	Eddie Collins E. Collins	1,458	Red Sox	407	242	493	69	25	6		191	14		96		1,730	630	100	67				.338	.420	.432	.852
22	Tristram Speaker T. Speaker	1,448	Browns	392	286	519	100	32	21		196	15		65		1,698	746	153	39				.358	.440	.515	.955
23	Pete Rose P. Rose	1,447	Astros	366	225	451	76	15	9	143	175	9	143	18	14	1,644	584	100	4	9	15	24	.312	.387	.404	.791
24	Hank Aaron H. Aaron	1,444	Dodgers	391	246	436	79	11	95	247	199	5	175	21	3	1,664	822	185	6	10	49	42	.302	.386	.569	.955
25	Eddie Collins E. Collins	1,430	Tigers	405	292	499	69	24	5		242	11		125		1,760	631	98	77				.349	.447	.441	.888