Vladimir Guerrero Jr. had the most at-bats by a first baseman in 2022, with 638 at-bats.

	NAME	AB	SEASON	TM	G	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Vladimir Guerrero Jr. V. Guerrero Jr.	638	2022	TOR	160	90	175	35	0	32	97	58	6	116	8	3	706	306	67	0	4	6	26	.274	.339	.480	.818	104	23.4	.351	132	25.5
2	Matt Olson M. Olson	616	2022	ATL	162	86	148	44	0	34	103	75	4	170	0	0	699	294	78	0	4	6	13	.240	.325	.477	.802	99	18.9	.344	121	16.8
3	Freddie Freeman F. Freeman	612	2022	LAD	159	117	199	47	2	21	100	84	5	102	13	3	708	313	70	0	7	12	6	.325	.407	.511	.918	128	46.6	.393	158	47.7
4	José Abreu J. Abreu	601	2022	CWS	157	85	183	40	0	15	75	62	12	110	0	0	679	268	55	0	4	2	19	.304	.378	.446	.824	106	27.8	.361	137	28.3
5	Pete Alonso P. Alonso	597	2022	NYM	160	95	162	27	0	40	131	67	12	128	5	1	685	309	67	0	9	16	17	.271	.352	.518	.869	109	30.5	.366	142	33.1
6	Nathaniel Lowe N. Lowe	593	2022	TEX	157	74	179	26	3	27	76	48	4	147	2	2	645	292	56	0	0	2	10	.302	.358	.492	.851	104	30	.368	141	29.7
7	Rhys Hoskins R. Hoskins	589	2022	PHI	156	81	145	33	2	30	79	72	6	169	2	1	671	272	65	0	4	0	12	.246	.332	.462	.794	96	18.9	.345	123	17.7
8	Christian Walker C. Walker	583	2022	ARI	160	84	141	25	2	36	94	69	8	131	2	2	667	278	63	0	7	2	15	.242	.327	.477	.804	96	19.3	.346	123	18.1
9	C.J. Cron	575	2022	COL	150	79	148	28	3	29	102	43	8	164	0	0	631	269	60	0	5	6	16	.257	.315	.468	.783	85	12.5	.335	101	0.6
10	Paul Goldschmidt P. Goldschmidt	561	2022	STL	151	106	178	41	0	35	115	79	5	141	7	0	649	324	76	0	4	1	7	.317	.404	.578	.981	131	56.5	.419	176	57.5
11	Ryan Mountcastle R. Mountcastle	555	2022	BAL	145	62	139	28	1	22	85	43	4	154	4	1	609	235	51	0	7	1	12	.250	.305	.423	.729	73	3	.316	108	5.5
12	Josh Bell J. Bell	552	2022	TOT	156	78	147	29	3	17	71	81	5	102	0	1	644	233	49	0	6	4	22	.266	.362	.422	.784	91	17.4	.344	124	17.6
13	Ty France T. France	551	2022	SEA	140	65	151	27	1	20	83	35	21	94	0	0	612	240	48	0	5	3	18	.274	.338	.436	.774	83	13.3	.337	125	17.2
14	Luis Arraez L. Arraez	547	2022	MIN	144	88	173	31	1	8	49	50	3	43	4	4	603	230	40	0	3	2	6	.316	.375	.420	.795	88	19	.350	131	20.8
15	Yuli Gurriel Y. Gurriel	545	2022	HOU	146	53	132	40	0	8	53	30	6	73	8	0	584	196	48	0	3	0	13	.242	.288	.360	.647	55	-11.6	.285	85	-9.9
16	Rowdy Tellez R. Tellez	529	2022	MIL	153	67	116	23	0	35	89	62	5	121	2	1	599	244	58	0	3	9	20	.219	.306	.461	.767	77	8.2	.327	110	7.1
17	Seth Brown S. Brown	500	2022	OAK	150	55	115	26	3	25	73	51	3	146	11	2	555	222	54	0	1	3	7	.230	.305	.444	.749	70	6	.323	116	10.2
18	Anthony Rizzo A. Rizzo	465	2022	NYY	130	77	104	21	1	32	75	58	23	101	6	5	548	223	54	0	2	6	13	.224	.338	.480	.817	81	18.5	.352	134	20.8
19	Jesus Aguilar J. Aguilar	464	2022	TOT	129	39	109	19	0	16	51	28	4	119	1	0	501	176	35	0	5	1	8	.235	.281	.379	.661	49	-8.6	.288	84	-9.3
20	Hunter Dozier H. Dozier	462	2022	KCR	128	51	109	26	4	12	41	34	3	125	4	3	500	179	42	0	1	0	14	.236	.292	.387	.679	52	-4.8	.298	89	-6.1
21	Josh Naylor J. Naylor	449	2022	CLE	122	47	115	28	0	20	79	38	6	80	6	1	498	203	48	0	5	4	13	.256	.319	.452	.771	66	8.6	.331	119	10.6
22	Jose Miranda J. Miranda	444	2022	MIN	125	45	119	25	0	15	66	28	10	91	1	1	483	189	40	0	1	0	19	.268	.325	.426	.751	63	7.4	.329	116	8.8
23	Owen Miller O. Miller	424	2022	CLE	130	53	103	26	1	6	51	32	7	93	2	0	472	149	33	0	9	1	8	.243	.301	.351	.652	45	-8.6	.287	87	-6.7
24	Jared Walsh J. Walsh	423	2022	LAA	118	41	91	18	2	15	44	27	4	138	2	1	454	158	35	0	0	4	6	.215	.269	.374	.642	41	-11.4	.278	77	-11.6
25	Harold Castro H. Castro	420	2022	DET	120	37	114	21	2	7	47	17	1	79	0	1	443	160	30	3	2	1	5	.271	.300	.381	.681	46	-4.6	.297	92	-3.8