Eddie Murray has the most career games by a first baseman, with 2,438 games.

Interpreted as:

most career regular-season games first baseman

	NAME	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Eddie Murray E. Murray	2,438	9,123	1,339	2,647	461	31	414	1,574	1,139	17	1,181	92	37	10,382	4,412	906	2	101	199	244	.290	.366	.484	.850	1594	423.6	.372	134	407.4
2	Mickey Vernon M. Vernon	2,400	8,723	1,196	2,494	490	120	172	1,310	954	49	869	137	31	9,825	3,740	782	80	19	21	183	.286	.359	.429	.788	1349	230.2	.363	115	169.6
3	Jake Beckley J. Beckley	2,389	9,538	1,602	2,934	473	244	87	1,578	616	183	442	315		10,504	4,156	804	167				.308	.361	.436	.797	1803	356.2	.376	119	288.8
4	Fred McGriff F. McGriff	2,323	8,385	1,283	2,403	422	24	471	1,500	1,236	38	1,757	69	36	9,732	4,286	917	2	71	165	222	.287	.378	.511	.889	1613	444.1	.384	135	408.1
5	Paul Konerko P. Konerko	2,262	8,178	1,147	2,296	402	8	434	1,390	910	100	1,338	9	4	9,273	4,016	844	1	84	80	274	.281	.357	.491	.848	1405	283.3	.364	120	224.9
6	Rafael Palmeiro R. Palmeiro	2,261	8,472	1,359	2,434	474	29	459	1,480	1,110	74	1,136	78	31	9,767	4,343	962	13	98	142	193	.287	.371	.513	.884	1595	418.3	.379	130	367.8
7	Mark Grace M. Grace	2,245	8,065	1,179	2,445	511	45	173	1,146	1,075	34	642	70	48	9,290	3,565	729	17	99	114	192	.303	.383	.442	.825	1393	277.1	.364	120	225.5
8	Willie McCovey W. McCovey	2,215	7,040	1,030	1,906	314	39	439	1,345	1,205	53	1,323	20	17	8,364	3,615	792	4	62	249	151	.271	.378	.513	.892	1379	478.9	.389	145	432
9	Todd Helton T. Helton	2,212	7,869	1,388	2,493	590	36	364	1,395	1,327	57	1,164	37	28	9,349	4,247	990	3	93	185	185	.317	.415	.540	.955	1750	610.4	.406	132	390.6
10	Chris Chambliss C. Chambliss	2,174	7,570	912	2,109	392	42	185	972	632	27	925	40	35	8,304	3,140	619	19	56	99	166	.279	.334	.415	.749	1017	106.1	.335	108	73.7
11	Joe Judge J. Judge	2,171	7,898	1,184	2,352	433	159	71	1,034	965	51	478	213		9,171	3,316	663	257				.298	.378	.420	.798	1337	245.9	.374	116	184.3
12	Lou Gehrig L. Gehrig	2,164	8,001	1,888	2,721	534	163	493	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
13	Charlie Grimm C. Grimm	2,154	7,895	908	2,297	394	108	79	1,077	576	31	406	57		8,721	3,144	581	219				.291	.342	.398	.740	1075	-7.2	.343	95	-47.9
14	Jeff Bagwell J. Bagwell	2,150	7,797	1,517	2,314	488	32	449	1,529	1,401	128	1,558	202	78	9,431	4,213	969	3	102	155	221	.297	.408	.540	.948	1755	596.6	.405	149	588.3
15	Jimmie Foxx J. Foxx	2,148	7,673	1,656	2,498	425	114	521	1,836	1,389	12	1,256	83		9,131	4,714	1,060	57			69	.326	.430	.614	1.044	2036	900.3	.463	159	752
16	Andres Galarraga A. Galarraga	2,136	7,697	1,145	2,231	416	31	382	1,356	552	166	1,886	127	78	8,471	3,855	829	1	55	104	167	.290	.348	.501	.849	1296	283.1	.366	118	193
17	John Olerud J. Olerud	2,123	7,234	1,096	2,144	485	12	241	1,182	1,218	87	941	11	12	8,642	3,376	738	11	92	151	227	.296	.400	.467	.866	1407	344.6	.378	130	332.5
18	Steve Garvey S. Garvey	2,118	8,220	1,072	2,443	409	40	255	1,246	433	28	916	77	57	8,797	3,697	704	32	84	108	234	.297	.331	.450	.781	1149	168.5	.344	117	172.4
19	Joe Kuhel J. Kuhel	2,101	7,981	1,236	2,212	412	111	131	1,049	980	39	609	178		9,092	3,239	654	92			74	.277	.359	.406	.765	1233	156.4	.357	105	59
20	Albert Pujols A. Pujols	2,096	7,766	1,332	2,307	479	9	494	1,485	999	76	899	100	32	8,925	4,286	982	0	84	265	291	.297	.379	.552	.931	1554	497.4	.389	144	489.6
21	Cap Anson C. Anson	2,092	8,279	1,552	2,727	489	114	95	1,306	919	32	146	247		9,264	3,729	698	34				.329	.398	.450	.849	1973	596.5	.399	134	475.5
22	Keith Hernandez K. Hernandez	2,088	7,370	1,124	2,182	426	60	162	1,071	1,070	32	1,012	98	63	8,553	3,214	648	10	71	130	161	.296	.384	.436	.821	1270	305.9	.365	130	299.4
23	Ed Konetchy E. Konetchy	2,085	7,649	972	2,150	344	182	74	992	689	73	719	255		8,664	3,080	600	253				.281	.346	.403	.749	1146	233.6	.360	119	187
24	Norm Cash N. Cash	2,076	6,697	1,043	1,818	241	41	377	1,104	1,043	90	1,090	43	30	7,902	3,272	659	17	55	112	139	.271	.374	.489	.863	1274	428.3	.382	139	356.2
25	Stuffy McInnis S. McInnis	2,071	7,703	857	2,372	310	97	19	1,047	371	37	243	169		8,492	2,933	426	381				.308	.343	.381	.724	1021	66.4	.343	103	25.9