most career games with 6 strikeout by a pitcher

Nolan Ryan had the most games pitched when striking out 6+ batters, with 517 games.

Interpreted as:

most career regular-season games with 6 or more strikeout by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	517	4,801	260	164	.613	515	2.44	205	60	0	4002.0	2,574	1,087	1,241	201	1,875	101	1	52	16,266	197	10.80	4.22	2.56	0.45	29.5	11.5	1.11	.255	2.79	5.79
2	Randy Johnson R. Johnson	447	4,312	254	100	.718	445	2.61	97	37	1	3270.2	2,369	949	1,059	288	1,055	144	2	29	13,095	71	11.87	2.90	4.09	0.79	32.9	8.1	1.05	.285	2.91	6.52
3	Roger Clemens R. Clemens	443	3,721	249	89	.737	443	2.47	100	38	0	3287.0	2,523	901	997	215	973	92	0	40	13,200	83	10.19	2.66	3.82	0.59	28.2	7.4	1.06	.281	2.73	6.91
4	Max Scherzer M. Scherzer	350	3,009	188	68	.734	349	2.61	12	5	0	2309.2	1,691	670	713	243	563	81	0	18	9,105	53	11.73	2.19	5.34	0.95	33.0	6.2	0.98	.278	2.78	6.59
5	Steve Carlton S. Carlton	349	2,910	211	90	.701	349	2.50	179	30	0	2834.0	2,237	786	872	180	908	20	0	73	11,420	99	9.24	2.88	3.20	0.57	25.5	8.0	1.11	.278	2.77	7.10
6	Justin Verlander J. Verlander	335	2,722	190	68	.736	335	2.54	20	8	0	2278.0	1,677	643	693	209	552	70	0	16	8,997	63	10.75	2.18	4.93	0.83	30.3	6.1	0.98	.270	2.74	6.63
7	Bert Blyleven B. Blyleven	310	2,431	171	83	.673	310	2.28	166	45	0	2539.0	2,000	643	722	164	621	74	0	28	10,090	48	8.62	2.20	3.91	0.58	24.1	6.2	1.03	.270	2.56	7.09
8	Tom Seaver T. Seaver	306	2,519	184	72	.719	306	2.23	154	36	0	2498.1	1,814	619	665	184	648	34	0	47	9,809	52	9.07	2.33	3.89	0.66	25.7	6.6	0.99	.254	2.40	6.53
9	Clayton Kershaw C. Kershaw	293	2,435	171	54	.760	293	2.09	20	13	0	1996.0	1,395	463	505	155	420	27	0	13	7,698	68	10.98	1.89	5.80	0.70	31.6	5.5	0.91	.266	2.28	6.29
10	Pedro Martinez P. Martinez	293	2,613	164	58	.739	292	2.31	42	17	0	2094.1	1,473	537	591	151	505	93	1	18	8,220	47	11.23	2.17	5.17	0.65	31.8	6.1	0.94	.272	2.54	6.33
11	Bob Gibson B. Gibson	286	2,371	175	87	.668	285	2.34	193	44	0	2438.1	1,891	635	729	138	727	62	0	58	9,842	57	8.75	2.68	3.26	0.51	24.1	7.4	1.07	.268	2.69	6.98
12	Don Sutton D. Sutton	267	2,003	144	69	.676	267	2.26	114	36	0	2136.1	1,607	536	593	141	478	30	0	38	8,421	47	8.44	2.01	4.19	0.59	23.8	5.7	0.98	.254	2.50	6.77
13	John Smoltz J. Smoltz	264	2,045	137	65	.678	264	2.60	42	14	0	1916.2	1,496	553	613	140	508	31	0	47	7,653	74	9.60	2.39	4.03	0.66	26.7	6.6	1.05	.275	2.88	7.02
14	Curt Schilling C. Schilling	261	2,295	143	66	.684	261	2.84	54	14	0	1938.0	1,624	612	639	180	356	33	0	18	7,691	45	10.66	1.65	6.45	0.84	29.8	4.6	1.02	.299	2.97	7.54
15	CC Sabathia	260	2,014	145	56	.721	260	2.70	29	11	0	1815.0	1,508	544	600	151	468	52	0	21	7,307	30	9.99	2.32	4.30	0.75	27.6	6.4	1.09	.294	2.98	7.48
16	Gaylord Perry G. Perry	254	1,995	146	74	.664	250	2.21	158	25	0	2176.0	1,701	534	628	148	521	44	0	56	8,644	55	8.25	2.15	3.83	0.61	23.1	6.0	1.02	.262	2.60	7.04
17	Greg Maddux G. Maddux	252	1,806	147	61	.707	252	2.35	63	21	0	1894.0	1,549	494	566	101	336	55	0	59	7,502	31	8.58	1.60	5.38	0.48	24.1	4.5	1.00	.278	2.69	7.36
18	Fergie Jenkins F. Jenkins	252	1,970	161	69	.700	249	2.41	167	32	0	2127.0	1,659	570	643	197	388	47	2	45	8,383	34	8.34	1.64	5.08	0.83	23.5	4.6	0.96	.253	2.72	7.02
19	Chris Sale C. Sale	249	2,195	123	57	.683	249	2.66	16	3	0	1653.0	1,264	489	533	161	370	94	0	7	6,574	34	11.95	2.01	5.93	0.88	33.4	5.6	0.99	.294	2.90	6.88
20	Cole Hamels C. Hamels	246	1,900	111	55	.669	246	2.57	10	4	0	1691.0	1,336	482	522	175	403	50	0	25	6,719	27	10.11	2.14	4.71	0.93	28.3	6.0	1.03	.277	2.78	7.11
21	Zack Greinke Z. Greinke	245	1,881	134	46	.744	245	2.48	9	3	0	1645.0	1,328	454	488	138	315	31	0	7	6,463	50	10.29	1.72	5.97	0.76	29.1	4.9	1.00	.290	2.67	7.27
22	Walter Johnson W. Johnson	241	1,915	168	65	.721	236	0.96	224	60	0	2194.1	1,528		489	21	456	78	5		8,469	73	7.85	1.87	4.20	0.09	22.6	5.4	0.90	.251	2.01	6.27
23	David Cone D. Cone	237	1,953	130	56	.699	236	2.56	40	14	0	1731.2	1,309	492	559	132	605	54	0	21	7,047	87	10.15	3.14	3.23	0.69	27.7	8.6	1.11	.274	2.91	6.80
24	Felix Hernandez F. Hernandez	235	1,853	111	53	.677	235	2.34	19	9	0	1661.1	1,271	432	482	116	402	53	0	7	6,567	93	10.04	2.18	4.61	0.63	28.2	6.1	1.01	.279	2.61	6.89
25	Jim Bunning J. Bunning	234	1,853	136	50	.731	233	2.10	107	29	0	1917.2	1,447	447	513	160	452	69	1	35	7,623	19	8.70	2.12	4.10	0.75	24.3	5.9	0.99	.253	2.41	6.79