Mark McGwire has crushed the most career homers by a first baseman, with 580 home runs.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Mark McGwire M. McGwire	580	1,856	6,134	1,157	1,616	251	6	1,405	1,313	74	1,578	12	7	7,602	3,619	837	3	78	150	147	.263	.395	.590	.985	1475	566.5	.416	158	559.7
2	Jimmie Foxx J. Foxx	521	2,148	7,673	1,656	2,498	425	114	1,836	1,389	12	1,256	83		9,131	4,714	1,060	57			69	.326	.430	.614	1.044	2036	900.3	.463	159	752
3	Albert Pujols A. Pujols	494	2,096	7,766	1,332	2,307	479	9	1,485	999	76	899	100	32	8,925	4,286	982	0	84	265	291	.297	.379	.552	.931	1554	497.4	.389	144	489.6
4	Lou Gehrig L. Gehrig	493	2,164	8,001	1,888	2,721	534	163	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
5	Fred McGriff F. McGriff	471	2,323	8,385	1,283	2,403	422	24	1,500	1,236	38	1,757	69	36	9,732	4,286	917	2	71	165	222	.287	.378	.511	.889	1613	444.1	.384	135	408.1
6	Rafael Palmeiro R. Palmeiro	459	2,261	8,472	1,359	2,434	474	29	1,480	1,110	74	1,136	78	31	9,767	4,343	962	13	98	142	193	.287	.371	.513	.884	1595	418.3	.379	130	367.8
7	Jeff Bagwell J. Bagwell	449	2,150	7,797	1,517	2,314	488	32	1,529	1,401	128	1,558	202	78	9,431	4,213	969	3	102	155	221	.297	.408	.540	.948	1755	596.6	.405	149	588.3
8	Willie McCovey W. McCovey	439	2,215	7,040	1,030	1,906	314	39	1,345	1,205	53	1,323	20	17	8,364	3,615	792	4	62	249	151	.271	.378	.513	.892	1379	478.9	.389	145	432
9	Carlos Delgado C. Delgado	436	1,815	6,573	1,149	1,863	450	16	1,385	1,019	160	1,534	13	7	7,834	3,653	902	0	82	180	133	.283	.388	.556	.944	1402	429.9	.396	139	394.7
10	Paul Konerko P. Konerko	434	2,262	8,178	1,147	2,296	402	8	1,390	910	100	1,338	9	4	9,273	4,016	844	1	84	80	274	.281	.357	.491	.848	1405	283.3	.364	120	224.9
11	Eddie Murray E. Murray	414	2,438	9,123	1,339	2,647	461	31	1,574	1,139	17	1,181	92	37	10,382	4,412	906	2	101	199	244	.290	.366	.484	.850	1594	423.6	.372	134	407.4
12	Mark Teixeira M. Teixeira	409	1,862	6,936	1,099	1,862	408	18	1,298	918	111	1,441	26	7	8,029	3,533	835	0	64	91	158	.268	.360	.509	.869	1268	317.6	.371	127	262.4
13	Ryan Howard R. Howard	382	1,572	5,707	848	1,475	277	21	1,194	709	59	1,843	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
14	Andres Galarraga A. Galarraga	382	2,136	7,697	1,145	2,231	416	31	1,356	552	166	1,886	127	78	8,471	3,855	829	1	55	104	167	.290	.348	.501	.849	1296	283.1	.366	118	193
15	Norm Cash N. Cash	377	2,076	6,697	1,043	1,818	241	41	1,104	1,043	90	1,090	43	30	7,902	3,272	659	17	55	112	139	.271	.374	.489	.863	1274	428.3	.382	139	356.2
16	Paul Goldschmidt P. Goldschmidt	372	2,074	7,608	1,280	2,190	477	24	1,232	1,086	53	1,979	174	36	8,804	3,831	873	0	57	121	174	.288	.378	.504	.882	1462	430.2	.375	137	385.9
17	Gil Hodges G. Hodges	369	2,042	6,951	1,096	1,909	292	47	1,267	928	25	1,116	62	31	8,010	3,402	708	56	50	31	162	.275	.360	.489	.849	1237	308.2	.380	121	215.2
18	Freddie Freeman F. Freeman	367	2,179	8,114	1,379	2,431	547	33	1,322	1,070	113	1,763	104	32	9,363	4,145	947	0	66	142	172	.300	.386	.511	.897	1600	506.4	.381	142	474.4
19	Todd Helton T. Helton	364	2,212	7,869	1,388	2,493	590	36	1,395	1,327	57	1,164	37	28	9,349	4,247	990	3	93	185	185	.317	.415	.540	.955	1750	610.4	.406	132	390.6
20	Johnny Mize J. Mize	359	1,884	6,443	1,118	2,011	367	83	1,337	856	52	524	28	0	7,371	3,621	809	20			76	.312	.397	.562	.959	1421	546.3	.433	157	508.1
21	Joey Votto J. Votto	356	2,056	7,252	1,171	2,135	459	22	1,144	1,365	81	1,640	80	29	8,746	3,706	837	0	48	147	168	.294	.409	.511	.920	1563	539.6	.394	145	472.9
22	Jason Giambi J. Giambi	352	1,745	5,626	987	1,598	314	7	1,147	1,101	142	1,212	15	9	6,942	2,982	673	1	72	78	129	.284	.409	.530	.939	1284	425.9	.403	145	401.8
23	Tino Martinez T. Martinez	339	2,023	7,111	1,009	1,925	365	21	1,271	780	59	1,069	27	20	8,044	3,349	725	14	80	102	191	.271	.344	.471	.815	1126	132.8	.350	110	108.3
24	Jim Thome J. Thome	337	1,238	4,272	836	1,190	229	12	909	947	32	1,338	4	9	5,292	2,454	578	0	41	107	64	.279	.410	.574	.984	1026	365.8	.414	150	336.9
25	Orlando Cepeda O. Cepeda	334	1,798	6,701	996	2,000	351	24	1,165	495	90	981	126	72	7,355	3,401	709	2	67	132	178	.298	.352	.508	.859	1145	351.5	.374	134	289.8